DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sulf1 and GALNS

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_011521284.1	Gene:	GALNS / 2588	HGNCID:	4122	Length:	581	Species:	Homo sapiens

Alignment Length:	502	Identity:	109/502 - (21%)
Similarity:	183/502 - (36%)	Gaps:	164/502 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GAEFRHAYTTTPMCCPARSSLLTGMYVHNHMVFTNN---DNCSSPQ---------WQATHETRSY 137
            |..|.:.|:..|:|.|:|::||||.....:..:|.|   .|..:||         .|...|....
Human    72 GLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKK 136

  Fly   138 ATYLS------NAGYRTGY-----------------FGKYLNKYNGSYIPPGWREWGGLIMNSKY 179
            |.|:|      :.|:|..:                 ||.|.||...:.  |.:|:|.   |..:|
Human   137 AGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNI--PVYRDWE---MVGRY 196

  Fly   180 Y-NYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPAPHGPEDSAP 243
            | .:.|||     |.|.......|    ..:::.|:   |:|.:..|..|..:..|.|     ||
Human   197 YEEFPINL-----KTGEANLTQIY----LQEALDFI---KRQARHHPFFLYWAVDATH-----AP 244

  Fly   244 QYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTLQSVDVAVERVY 308
            .|:...| :.|.....|..|                                 ::.:|.::.::.
Human   245 VYASKPF-LGTSQRGRYGDA---------------------------------VREIDDSIGKIL 275

  Fly   309 NELKELGELDNTYIVYTSDHGYHL-------GQFG-LIKGKSFPFEFDVRVPFLIRGPG-IQASK 364
            ..|::|...|||::.:|||:|..|       |..| .:.||...||..:|.|.|...|| :.|.:
Human   276 ELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQ 340

  Fly   365 VVNEIVLNVDLAPTFLDMGGV--PTPQHMDGRSILPLLLS---RNRAVRDNWPDSFLIESSGRRE 424
            |.:::...:||..|.|.:.|:  |:.:.:||.::||.||.   .:|.:.....|:.:..:.|:.:
Human   341 VSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHK 405

  Fly   425 ----------------------------TAEQIAESRARLQI---------ERRNMKLANSSLLE 452
                                        |...: |...:|.:         ||..:..|::
Human   406 AHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNL-EDHTKLPLIFHLGRDPGERFPLSFASA---- 465

  Fly   453 DFLEGAGESTTIVSSSSTA----------------ATLMSSTAQQPE 483
            ::.|.....|::|.....|                |...|||:.||:
Human   466 EYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMAPTQSSTSVQPD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	86/359 (24%)
		G6S	53..408	CDD:293766	91/372 (24%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
GALNS	XP_011521284.1	GALNS	46..500	CDD:293776	103/488 (21%)
GALNS	XP_011521284.1	AslA	46..489	CDD:225661	103/477 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810