DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sulf1 and Sulf1

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_006495573.1	Gene:	Sulf1 / 240725	MGIID:	2138563	Length:	1121	Species:	Mus musculus

Alignment Length:	1143	Identity:	398/1143 - (34%)
Similarity:	551/1143 - (48%)	Gaps:	295/1143 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AKRF-SRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPAR 102
            ::|| .|.....:..||||||:||||||||||||..|.:|.:::..|||.|.:|:.|||||||:|
Mouse    27 SQRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEQGGATFTNAFVTTPMCCPSR 91

  Fly   103 SSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGW 167
            ||:|||.|||||.|:|||:|||||.|||.||.|::|.||:|.||||.:||||||:||||||||||
Mouse    92 SSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGW 156

  Fly   168 REWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSF 232
            |||.|||.||::|||::..||.|.||||||||||:.|||.|:||.:.:.||:....:|:::.:|.
Mouse   157 REWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPIMMVISH 221

  Fly   233 PAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTL 297
            .|||||||||||:|.|:.|.:.|.||||::|||.||.||::.|.||.|:|..|||:|..||||||
Mouse   222 AAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLQRKRLQTL 286

  Fly   298 QSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQA 362
            .|||.:|||:||.|.|.||||||||:||:|||||:|||||:||||.|::||:||||.||||.|:.
Mouse   287 MSVDDSVERLYNMLVESGELDNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSIEP 351

  Fly   363 SKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLL-LSR--NRAVRDN-----WPDSFLIES 419
            ..:|.:||||:|||||.||:.|:.:|..:||:|:|.|| |.:  || .|.|     |.|:||:|.
Mouse   352 GSIVPQIVLNIDLAPTILDIAGLDSPSDVDGKSVLKLLDLEKPGNR-FRTNKKAKIWRDTFLVER 415

  Fly   420 SGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPED 484

Mouse   416 ----------------------------------------------------------------- 415

  Fly   485 GEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMR 549
                                              ..|....||..:..||:|.||      |..|
Mouse   416 ----------------------------------GKFLRKKEESGKNIQQSNHLP------KYER 440

  Fly   550 LNSECSDPALLKNC-LPGQKWKCVNE-EGRWRKHKCKFHLQLEHQLAAMPRKQYQRNCACFTPDG 612
            :...|........| .|||.|:|:.: .|:.|.||||....|      :..:|..||
Mouse   441 VKELCQQARYQTACEQPGQNWQCIEDTSGKLRIHKCKGPSDL------LTVRQNARN-------- 491

  Fly   613 VVYTKIRAPSAGLHRVNKRTH-------NGPGRRRNKREVF-------------HT----ELPDE 653
             :|      |.|||..:|..|       :...:|:|:|:..             ||    .|..|
Mouse   492 -LY------SRGLHDKDKECHCRDSGYRSSRSQRKNQRQFLRNKGTPKYKPRFVHTRQTRSLSVE 549

  Fly   654 ME-ELLDLHQVVDQLV-----------DHTHRS-----------KRDLPASSNETIAQVIQQIQS 695
            .| |:.|::...::|.           |..|:.           :.::.|.||..:.     :.:
Mouse   550 FEGEIYDINLEEEELQVLPPRSIAKRHDEGHQGFIGHQAAAGDIRNEMLADSNNAVG-----LPA 609

  Fly   696 TLEILELKFNEHELHASNSSGNSYERGEKYTKSGGHRCFVDATTAKVNCSNVIYDDEKTWRTSRT 760
            |:.:.                              |:||: .....::|...:|...:.|:..:.
Mouse   610 TVRVT------------------------------HKCFI-LPNDTIHCERELYQSARAWKDHKA 643

  Fly   761 QIDMLIKLLKDKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPEFNMSYFTEIS 825
            .||..|::|:|||..|:|::..|::...:....|         ||             ||:.:..
Mouse   644 YIDKEIEVLQDKIKNLREVRGHLKKRKPEECGCG---------DQ-------------SYYNKEK 686

  Fly   826 STPRSNVVGQTEVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENHADSKEMAREARRKL- 889
            ...|.                     |:.:||.                |...:..|:|...||
Mouse   687 GVKRQ---------------------EKLKSHL----------------HPFKEAAAQEVDSKLQ 714

  Fly   890 --KEERQRKKERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMNANNNTYSCLR 952
              ||.|:||||||..|:.|..:||....:.||:|||.||:|||.||...||.|.::|||||.|||
Mouse   715 LFKEHRRRKKERKEKKRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR 779

  Fly   953 TINGTHNFLYCEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSCRG-RSCSIRR 1016
            |:|.|||||:|||.||.:.::::..|.::..|....:.....:.:|..|.:|:||:| :.|:.|.
Mouse   780 TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERSILNQLHIQLMELRSCQGYKQCNPRP 844

  Fly  1017 HQNHLEG--GSSAPLLPINQVHRNNKRKHSPLAGA--VGNYAFVGPRLDMEALPPIKRRKLSKYN 1077
            ....:|.  |....:...|.....:.:....|:||  :..|. ..|||.:|......|.....:.
Mouse   845 KSLDIEDSYGMDGKVSQSNITSDTSWQGLEELSGASNIDEYR-SNPRLSLEDWTNYLRAVYRAFA 908

  Fly  1078 RLTGSQQSHMKRRPWKQTPLQQSPRFLRTHS--VTPAQ 1113
            .|    .||........||..|...||.|.:  :.||:
Mouse   909 LL----NSHPDPNKANGTPTTQGGDFLVTSAERLVPAE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	220/346 (64%)
		G6S	53..408	CDD:293766	226/357 (63%)
		DUF3740	640..790	CDD:289325	32/189 (17%)
		ALP_like	<940..989	CDD:304875	23/48 (48%)
Sulf1	XP_006495573.1	G6S	42..384	CDD:293766	218/341 (64%)
		DUF3740	534..674	CDD:403667	42/188 (22%)
		ALP_like	<767..816	CDD:419962	6/48 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847546
Domainoid	1	1.000	483	1.000	Domainoid score	I402
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	684	1.000	Inparanoid score	I709
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46462
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	1	1.000	-	-		otm43135
orthoMCL	1	0.900	-	-		OOG6_104964
Panther	1	1.100	-	-	O	PTHR43108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2825
SonicParanoid	1	1.000	-	-		X1396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790