Protein Alignment Sulf1 and Sulf1

DIOPT Version :10

• Sequence 1: NP_524987.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_006495573.1
• Gene: Sulf1 / 240725
• MGIID: 2138563
• Length: 1121
• Species: Mus musculus
• Alignment Length: 1133
• Identity: 398/1133 - (35%)
• Similarity: 548/1133 - (48%)
• Gaps: 275/1133 - (24%)

  Fly    39 AKRF-SRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPAR 102
            ::|| .|.....:..||||||:||||||||||||..|.:|.:::..|||.|.:|:.|||||||:|
Mouse    27 SQRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEQGGATFTNAFVTTPMCCPSR 91

  Fly   103 SSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGW 167
            ||:|||.|||||.|:|||:|||||.|||.||.|::|.||:|.||||.:||||||:||||||||||
Mouse    92 SSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGW 156

  Fly   168 REWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSF 232
            |||.|||.||::|||::..||.|.||||||||||:.|||.|:||.:.:.||:....:|:::.:|.
Mouse   157 REWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPIMMVISH 221

  Fly   233 PAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTL 297
            .|||||||||||:|.|:.|.:.|.||||::|||.||.||::.|.||.|:|..|||:|..||||||
Mouse   222 AAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLQRKRLQTL 286

  Fly   298 QSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQA 362
            .|||.:|||:||.|.|.||||||||:||:|||||:|||||:||||.|::||:||||.||||.|:.
Mouse   287 MSVDDSVERLYNMLVESGELDNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSIEP 351

  Fly   363 SKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLL-LSR--NRAVRDN-----WPDSFLIES 419
            ..:|.:||||:|||||.||:.|:.:|..:||:|:|.|| |.:  || .|.|     |.|:||:|.
Mouse   352 GSIVPQIVLNIDLAPTILDIAGLDSPSDVDGKSVLKLLDLEKPGNR-FRTNKKAKIWRDTFLVER 415

  Fly   420 SGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPED 484
                                                                             
Mouse   416 ----------------------------------------------------------------- 415

  Fly   485 GEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMR 549
                                              ..|....||..:..||:|.||      |..|
Mouse   416 ----------------------------------GKFLRKKEESGKNIQQSNHLP------KYER 440

  Fly   550 LNSECSDPALLKNC-LPGQKWKCVNE-EGRWRKHKCKFHLQLEHQLAAMPRKQYQRNCACFTPDG 612
            :...|........| .|||.|:|:.: .|:.|.||||....|      :..:|..||
Mouse   441 VKELCQQARYQTACEQPGQNWQCIEDTSGKLRIHKCKGPSDL------LTVRQNARN-------- 491

  Fly   613 VVYTKIRAPSAGLHRVNKRTH-------NGPGRRRNKREVFHTE-LPDEMEELLDLHQVVDQLVD 669
             :|      |.|||..:|..|       :...:|:|:|:....: .|......:
Mouse   492 -LY------SRGLHDKDKECHCRDSGYRSSRSQRKNQRQFLRNKGTPKYKPRFV----------- 538

  Fly   670 HTHRSKRDLPASSNETIAQVIQQIQSTLEILELKFNEHELHA--SNSSGNSYERGEK----YTKS 728
            || |..|.|             .::...||.::...|.||..  ..|....::.|.:    :..:
Mouse   539 HT-RQTRSL-------------SVEFEGEIYDINLEEEELQVLPPRSIAKRHDEGHQGFIGHQAA 589

  Fly   729 GG-----------------------HRCFVDATTAKVNCSNVIYDDEKTWRTSRTQIDMLIKLLK 770
            .|                       |:||: .....::|...:|...:.|:..:..||..|::|:
Mouse   590 AGDIRNEMLADSNNAVGLPATVRVTHKCFI-LPNDTIHCERELYQSARAWKDHKAYIDKEIEVLQ 653

  Fly   771 DKIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPEFNMSYFTEISSTPRSNVVGQ 835
            |||..|:|::..|::...:....|         ||             ||:.:.....|.
Mouse   654 DKIKNLREVRGHLKKRKPEECGCG---------DQ-------------SYYNKEKGVKRQ----- 691

  Fly   836 TEVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENHADSKEMAREARRKL---KEERQRKK 897
                            |:.:||.                |...:..|:|...||   ||.|:|||
Mouse   692 ----------------EKLKSHL----------------HPFKEAAAQEVDSKLQLFKEHRRRKK 724

  Fly   898 ERKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMNANNNTYSCLRTINGTHNFLY 962
            |||..|:.|..:||....:.||:|||.||:|||.||...||.|.::|||||.||||:|.|||||:
Mouse   725 ERKEKKRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLF 789

  Fly   963 CEFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSCRG-RSCSIRRHQNHLEG--G 1024
            |||.||.:.::::..|.::..|....:.....:.:|..|.:|:||:| :.|:.|.....:|.  |
Mouse   790 CEFATGFLEYFDMNTDPYQLTNTVHTVERSILNQLHIQLMELRSCQGYKQCNPRPKSLDIEDSYG 854

  Fly  1025 SSAPLLPINQVHRNNKRKHSPLAGA--VGNYAFVGPRLDMEALPPIKRRKLSKYNRLTGSQQSHM 1087
            ....:...|.....:.:....|:||  :..|. ..|||.:|......|.....:..|    .||.
Mouse   855 MDGKVSQSNITSDTSWQGLEELSGASNIDEYR-SNPRLSLEDWTNYLRAVYRAFALL----NSHP 914

  Fly  1088 KRRPWKQTPLQQSPRFLRTHS--VTPAQ 1113
            .......||..|...||.|.:  :.||:
Mouse   915 DPNKANGTPTTQGGDFLVTSAERLVPAE 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_524987.1	G6S	53..408	CDD:293766	226/357 (63%)
		DUF3740	637..793	CDD:463628	33/185 (18%)
		ALP_like	<940..989	CDD:474031	23/48 (48%)
Sulf1	XP_006495573.1	G6S	42..384	CDD:293766	218/341 (64%)
		DUF3740	534..678	CDD:463628	35/153 (23%)
		ALP_like	<767..816	CDD:474031	6/48 (13%)