Protein Alignment Sulf1 and SULF1

DIOPT Version :9

• Sequence 1: NP_001262626.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_006716501.1
• Gene: SULF1 / 23213
• HGNCID: 20391
• Length: 1122
• Species: Homo sapiens
• Alignment Length: 1123
• Identity: 402/1123 - (35%)
• Similarity: 550/1123 - (48%)
• Gaps: 254/1123 - (22%)

  Fly    41 RF-SRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPARSS 104
            || .|.....:..||||||:||||||||||||..|.:|.:::..|||.|.:|:.|||||||:|||
Human    29 RFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSS 93

  Fly   105 LLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGWRE 169
            :|||.|||||.|:|||:|||||.|||.||.|::|.||:|.||||.:||||||:||||||||||||
Human    94 MLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWRE 158

  Fly   170 WGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSFPA 234
            |.|||.||::|||::..||.|.||||||||||:.|||.|:||.:.:.||:....:||::.:|..|
Human   159 WLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAA 223

  Fly   235 PHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTLQS 299
            ||||||||||:|.|:.|.:.|.||||::|||.||.||::.|.||.|:|..|||:|..||||||.|
Human   224 PHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMS 288

  Fly   300 VDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQASK 364
            ||.:|||:||.|.|.|||:||||:||:|||||:|||||:||||.|::||:||||.||||.::...
Human   289 VDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGS 353

  Fly   365 VVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLL---LSRNRAVRDN-----WPDSFLIESSG 421
            :|.:||||:|||||.||:.|:.||..:||:|:|.||   ...|| .|.|     |.|:||:|.
Human   354 IVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNR-FRTNKKAKIWRDTFLVER-- 415

  Fly   422 RRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPEDGE 486
                                                                             
Human   416 ----------------------------------------------------------------- 415

  Fly   487 EEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMRLN 551
                                            ..|....||..:..||:|.||      |..|:.
Human   416 --------------------------------GKFLRKKEESSKNIQQSNHLP------KYERVK 442

  Fly   552 SECSDPALLKNC-LPGQKWKCVNE-EGRWRKHKCKFHLQL------EHQLAAMPRKQYQRNCACF 608
            ..|........| .|||||:|:.: .|:.|.||||....|      ...|.|.......:.|:|
Human   443 ELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSC- 506

  Fly   609 TPDGVVYTKIRAPSAGLHRVNKRTHNGPGRRRNKREV------FHTELPD---EMEELLDLHQV- 663
            ...|...::.:..|......|:.|.....|..:.|:.      |..|:.|   |.||.|.:.|.
Human   507 RESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPR 571

  Fly   664 -VDQLVDHTHRSKRDLPASSNETIAQVIQQIQSTLEILELKFNEHELHASNSSGNSYERGEKYTK 727
             :.:..|..|:..|||.|||..                    |...:.|.:|:.    .|...|.
Human   572 NIAKRHDEGHKGPRDLQASSGG--------------------NRGRMLADSSNA----VGPPTTV 612

  Fly   728 SGGHRCFVDATTAKVNCSNVIYDDEKTWRTSRTQIDMLIKLLKDKIGKLKEMKKQLRESNKQALA 792
            ...|:||: .....::|...:|...:.|:..:..||..|:.|:|||..|:|::..|:
Human   613 RVTHKCFI-LPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLK-------- 668

  Fly   793 AGRRNDNRRRNDQSVLDSGAGPEFNMSYFTEISSTPRSNVVGQTEVFQGYGSASAFDSLEQTQSH 857
                   ||:           ||       |.|.:.:|.          |.........|:.:||
Human   669 -------RRK-----------PE-------ECSCSKQSY----------YNKEKGVKKQEKLKSH 698

  Fly   858 RFTPRAECYCEPDVGENHADSKEMAREARRKL----KEERQRKKERKRIKKARLEKECLSEKMNC 918
                     ..|        .||.|:|...||    :..|:||||||..::.|..:||....:.|
Human   699 ---------LHP--------FKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSLPGLTC 746

  Fly   919 FSHDNQHWRTAPLWNDSPFCFCMNANNNTYSCLRTINGTHNFLYCEFTTGLITFYNLTIDRFETI 983
            |:|||.||:|||.||...||.|.::|||||.||||:|.|||||:|||.||.:.::::..|.::..
Human   747 FTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLT 811

  Fly   984 NRAAGLTPGERSHMHDALDQLKSCRG-RSCSIR------RHQNHLEGGSSAPLLP-------INQ 1034
            |....:..|..:.:|..|.:|:||:| :.|:.|      .....::|..:.|.|.       :.:
Human   812 NTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVEDSYGMDGKVNQPRLTADINWQGLEE 876

  Fly  1035 VHRNNKRKHSPLAGAVGNYAFVGPRLDMEALPPIKRRKLSKYNRLTGSQQSHMKRRPWKQTPLQQ 1099
            :|..|:..:....    ||     ||.:...    ...|...:|:....:||.::....:|...|
Human   877 LHSVNENIYEYRQ----NY-----RLSLVDW----TNYLKDLDRVFALLKSHYEQNKTNKTQTAQ 928

  Fly  1100 SPRFL---RTHSVTPAQA 1114
            |..||   ..|:|:...|
Human   929 SDGFLVVSAEHAVSMEMA 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	220/346 (64%)
		G6S	53..408	CDD:293766	225/357 (63%)
		DUF3740	640..790	CDD:289325	38/160 (24%)
		ALP_like	<940..989	CDD:304875	23/48 (48%)
SULF1	XP_006716501.1	AslA	42..>386	CDD:225661	220/343 (64%)
		G6S	42..384	CDD:293766	219/341 (64%)
		DUF3740	541..676	CDD:289325	43/192 (22%)
		ALP_like	<768..817	CDD:304875	23/48 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157139
Domainoid	1	1.000	483	1.000	Domainoid score	I405
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	691	1.000	Inparanoid score	I692
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46462
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	1	1.000	-	-		otm41064
orthoMCL	1	0.900	-	-		OOG6_104964
Panther	1	1.100	-	-	O	PTHR43108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2825
SonicParanoid	1	1.000	-	-		X1396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800