Protein Alignment Sulf1 and Sulf1

DIOPT Version :10

• Sequence 1: NP_524987.1
• Gene: Sulf1 / 53437
• FlyBaseID: FBgn0040271
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_599205.2
• Gene: Sulf1 / 171396
• RGDID: 708554
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 1044
• Identity: 384/1044 - (36%)
• Similarity: 523/1044 - (50%)
• Gaps: 265/1044 - (25%)

  Fly    39 AKRF-SRDSNSARERRPNIILILTDDQDVELGSLNFMPRTLRLLRDGGAEFRHAYTTTPMCCPAR 102
            ::|| .|.....:..||||||:||||||||||||..|.:|.:::..|||.|.:|:.|||||||:|
  Rat    27 SQRFRGRVQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFTNAFVTTPMCCPSR 91

  Fly   103 SSLLTGMYVHNHMVFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKYNGSYIPPGW 167
            ||:|||.|||||.|:|||:|||||.|||.||.|::|.||:|.||||.:||||||:||||||||||
  Rat    92 SSMLTGKYVHNHNVYTNNENCSSPSWQALHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGW 156

  Fly   168 REWGGLIMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLLTMSF 232
            |||.|||.||::|||::..||.|.||||||||||:.|||.|:||.:.:.||:....:||::.:|.
  Rat   157 REWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISH 221

  Fly   233 PAPHGPEDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQPVHKRFTNLLMTKRLQTL 297
            .|||||||||||:|.|:.|.:.|.||||::|||.||.||::.|.||.|:|..|||:|..||||||
  Rat   222 AAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLQRKRLQTL 286

  Fly   298 QSVDVAVERVYNELKELGELDNTYIVYTSDHGYHLGQFGLIKGKSFPFEFDVRVPFLIRGPGIQA 362
            .|||.:|||:||.|.|.|||.||||:||:|||||:|||||:||||.|::||:||||.||||.|:.
  Rat   287 MSVDDSVERLYNMLVETGELGNTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSIEP 351

  Fly   363 SKVVNEIVLNVDLAPTFLDMGGVPTPQHMDGRSILPLL-LSR--NRAVRDN-----WPDSFLIES 419
            ..:|.:||||:|||||.||:.|:.||..:||:|:|.|| |.:  || .|.|     |.|:||:|.
  Rat   352 GSIVPQIVLNIDLAPTILDIAGLDTPSDVDGKSVLKLLDLEKPGNR-FRTNKKAKIWRDTFLVER 415

  Fly   420 SGRRETAEQIAESRARLQIERRNMKLANSSLLEDFLEGAGESTTIVSSSSTAATLMSSTAQQPED 484
                                                                             
  Rat   416 ----------------------------------------------------------------- 415

  Fly   485 GEEEVETDNEEDDVDGDGAMDSSAAALEEDDLDDAAFEEGDEELDQEFQQNNDLPLAPYITKMMR 549
                                              ..|....||..:..||:|.||      |..|
  Rat   416 ----------------------------------GKFLRKKEESSKNIQQSNHLP------KYER 440

  Fly   550 LNSECSDPALLKNC-LPGQKWKCVNE-EGRWRKHKCKFHLQLEHQLAAMPRKQYQRNCACFTPDG 612
            :...|........| .|||.|:|:.: .|:.|.||||....|      :..:|..||
  Rat   441 VKELCQQARYQTACEQPGQNWQCIEDTSGKLRIHKCKGPSDL------LTVRQNARN-------- 491

  Fly   613 VVYTKIRAPSAGLHRVNKRTH---NG--PGRRRNKRE---------------VFHT----ELPDE 653
             :|      |.||...:|..|   :|  |.|.:.|:|               ..||    .|..|
  Rat   492 -LY------SRGLQDKDKECHCRESGYRPSRSQRKKERQFLRNQGTPKYKPRFVHTRQTRSLSVE 549

  Fly   654 ME-ELLDLHQVVDQLV-----------DHTHRSKRDLPASSNETIAQVIQQIQSTLEILELKFNE 706
            .| |:.|::...::|.           |..|:......|::.:                   |..
  Rat   550 FEGEIYDINLEEEELQVLPPRSVAKRHDEGHQGFGGHQAAAGD-------------------FRN 595

  Fly   707 HELHASNSSGNSYERGEKYTKSGGHRCFVDATTAKVNCSNVIYDDEKTWRTSRTQIDMLIKLLKD 771
            ..|..|||:     .|...|....|:||: .....::|...:|...:.|:..:..||..|::|:|
  Rat   596 EMLADSNSA-----VGLPTTVRVTHKCFI-LPNDTIHCERELYQSARAWKDHKAYIDKEIEVLQD 654

  Fly   772 KIGKLKEMKKQLRESNKQALAAGRRNDNRRRNDQSVLDSGAGPEFNMSYFTEISSTPRSNVVGQT 836
            ||..|:|::..|::...:..:.|::                      ||:.:.....|.
  Rat   655 KIKNLREVRGHLKKRKPEECSCGKQ----------------------SYYNKEKGVKRQ------ 691

  Fly   837 EVFQGYGSASAFDSLEQTQSHRFTPRAECYCEPDVGENHADSKEMAREARRKL---KEERQRKKE 898
                           |:.:||.                |...:..|:|...||   ||.|:||||
  Rat   692 ---------------EKLKSHL----------------HPFKEAAAQEVDSKLQLFKEHRRRKKE 725

  Fly   899 RKRIKKARLEKECLSEKMNCFSHDNQHWRTAPLWNDSPFCFCMNANNNTYSCLRTINGTHNFLYC 963
            ||..|:.|..:||....:.||:|||.||:|||.||...||.|.::|||||.||||:|.|||||:|
  Rat   726 RKEKKRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFC 790

  Fly   964 EFTTGLITFYNLTIDRFETINRAAGLTPGERSHMHDALDQLKSCRG-RSCSIRRHQNHL---EGG 1024
            ||.||.:.::::..|.::..|....:..|..:.:|..|.:|:||:| :.|:.|.....:   |||
  Rat   791 EFATGFLEYFDMNTDPYQLTNTVHTIERGILNQLHIQLMELRSCQGYKQCNPRPKSLDVGTKEGG 855

  Fly  1025 SSAP 1028
            :..|
  Rat   856 NYDP 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_524987.1	G6S	53..408	CDD:293766	227/357 (64%)
		DUF3740	637..793	CDD:463628	37/186 (20%)
		ALP_like	<940..989	CDD:474031	23/48 (48%)
Sulf1	NP_599205.2	Catalytic domain, necessary for arylsulfatase activity. /evidence=ECO:0000250|UniProtKB:Q8IWU5	1..414		237/395 (60%)
		G6S	42..384	CDD:293766	219/341 (64%)
		Hydrophilic domain, necessary for endoglucosamine-6-sulfatase activity. /evidence=ECO:0000250|UniProtKB:Q8IWU5	415..733		59/355 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..532		8/25 (32%)
		DUF3740	534..678	CDD:463628	41/181 (23%)
		ALP_like	<767..816	CDD:474031	4/48 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	847..870		1/22 (5%)