DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sulf1 and Arsa

DIOPT Version :9

Sequence 1:	NP_001262626.1	Gene:	Sulf1 / 53437	FlyBaseID:	FBgn0040271	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_033843.2	Gene:	Arsa / 11883	MGIID:	88077	Length:	506	Species:	Mus musculus

Alignment Length:	578	Identity:	140/578 - (24%)
Similarity:	208/578 - (35%)	Gaps:	173/578 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PNIILILTDDQDV-ELGSLNFMPRT---LRLLRDGGAEFRHAYTTTPMCCPARSSLLTG-MYVHN 113
            |||:||..||... :|||......|   |..|.:||..|...|....:|.|:|::|||| :.|.:
Mouse    20 PNILLIFADDLGYGDLGSYGHPSSTTPNLDQLAEGGLRFTDFYVPVSLCTPSRAALLTGRLPVRS 84

  Fly   114 HM---VFTNNDNCSSPQWQATHETRSYATYLSNAGYRTGYFGKYLNKY--NGSYIPP--GWREWG 171
            .|   |...:.....|..:.|     .|..|:..||.||..||:....  .|:::||  |:..:.
Mouse    85 GMYPGVLGPSSQGGLPLEEVT-----LAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 144

  Fly   172 GL--------IMNSKYYNYSINLNGQKIKHGFDYAKDYYPDLIANDSIAFLRSSKQQNQRKPVLL 228
            |:        ..|...:...|...|     |.|......| |:||                   |
Mouse   145 GIPYSHDQGPCQNLTCFPPDIPCKG-----GCDQGLVPIP-LLAN-------------------L 184

  Fly   229 TMSFPAPHGP--------------EDSAPQYSHLFFNVTTHHTPSYDHAPNPDKQWILRVTEPMQ 279
            |:....|..|              .|:..|....|....:|||    |.|
Mouse   185 TVEAQPPWLPGLEARYVSFSRDLMADAQRQGRPFFLYYASHHT----HYP--------------- 230

  Fly   280 PVHKRFTNLLMTKRL------QTLQSVDVAVERVYNELKELGELDNTYIVYTSDHGYHL------ 332
                :|:....|||.      .:|..:|.||..:...:.:||.|:.|.:::|:|:|..|
Mouse   231 ----QFSGQSFTKRSGRGPFGDSLMELDGAVGALMTTVGDLGLLEETLVIFTADNGPELMRMSNG 291

  Fly   333 GQFGLIK-GKSFPFEFDVRVPFLIRGPGIQASKVVNEIVLNVDLAPTFLDMGGVPTPQ-HMDGRS 395
            |..||:: ||...||..||.|.|:..||.....|.:|:..::||.||...:.|.|.|. .:||..
Mouse   292 GCSGLLRCGKGTTFEGGVREPALVYWPGHITPGVTHELASSLDLLPTLAALTGAPLPNVTLDGVD 356

  Fly   396 ILPLLLSRNRAVRDN------WPDS----FLIESSGRRETAEQIAESRARLQIERRNMKLANSSL 450
            |.||||...::.|.:      :||.    |.:                       ||.|..
Mouse   357 ISPLLLGTGKSPRKSVFFYPPYPDEIHGVFAV-----------------------RNGKYK---- 394

  Fly   451 LEDFLEGAGESTTIVSSSSTAATLMSSTAQQP----EDGEEEVETDNEEDDVDGDGAMDSSAAAL 511
            ...|.:|:..|.|....:..||..:  ||.:|    :..::..|..|..:.:  :|....:..||
Mouse   395 AHFFTQGSAHSDTTSDPACHAANRL--TAHEPPLLYDLSQDPGENYNVLESI--EGVSPEALQAL 455

  Fly   512 EEDDL----DDAAFEEGDEELDQEFQQNNDLPLAPYITKMMRLNSECSDPALLKNCLP 565
            :...|    .|||...|..::                       ::..||||...|.|
Mouse   456 KHIQLLKAQYDAAMTFGPSQI-----------------------AKGEDPALQICCQP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sulf1	NP_001262626.1	AslA	51..>398	CDD:225661	104/391 (27%)
		G6S	53..408	CDD:293766	108/401 (27%)
		DUF3740	640..790	CDD:289325
		ALP_like	<940..989	CDD:304875
Arsa	NP_033843.2	AslA	16..440	CDD:225661	125/501 (25%)
Arsa	NP_033843.2	ALP_like	19..502	CDD:304875	140/578 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740