DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c11.1 and AT2G36810

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	NP_181219.4	Gene:	AT2G36810 / 818253	AraportID:	AT2G36810	Length:	1716	Species:	Arabidopsis thaliana

Alignment Length:	1800	Identity:	369/1800 - (20%)
Similarity:	701/1800 - (38%)	Gaps:	403/1800 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 KLIDLALQELTKNPEHLPLIQNPAQRILVAIGRSSPE-SCEQVMEALQEKGTSTEGVAHFMLMQC 194
            ||..:|..|:..:.|.....|..|..:||:||...|: ..|::.  |...|.:|...|   ::|.
plant    93 KLAKIATAEIISSKELNADWQRQASGLLVSIGTHFPDLMMEEIF--LHLSGPATAAPA---MVQI 152

  Fly   195 LGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGRFSEAL------LEESGKKEE 253
            |...|:.:.....|.:|.:||:..|.|..:|..| :...|.|...:|:|:      |......:.
plant   153 LADFASSDALQFTPRLKGVLSKVSPILGNVRDIH-RPIFANAFKCWSQAVWLYITDLTSDSPLDS 216

  Fly   254 ENCSTEISVAYDVLFNQWLHSREPKVCVEILQALSSMYPLLPKDRIQDQAARLVPQILALYRRSV 318
            :..|...|| :::|...|..||:.||.|..:.||..|..|:.:.:::....||:|.||.||::
plant   217 DVMSFLNSV-FELLLRVWAVSRDHKVRVSTVDALGQMVGLITRTQLKSALPRLIPAILELYKK-- 278

  Fly   319 DRNAVTQFLCSVLKTNLALNATVLD----GIID-----VLVTHLFDLVCVYPDYEKPQTV----K 370
            |.:......||:  .|| |||::|.    .::|     ::::.|..::.:..:.::...:    |
plant   279 DHDDALLATCSL--HNL-LNASLLSESGPPLLDFEDLTIVLSTLLPVIGINNERKRFSDISVGRK 340

  Fly   371 GHYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIE 435
            .:.||.||| |..| ..|...:...||...:...:.....:|.||.|||........::.|..::
plant   341 TYNEVQRCF-LTVG-LVYPEDLFTFLLNKCKLKEDPLTFGALCILKHLLPRLFEAWHSKRPLLVD 403

  Fly   436 CLKQLILSERGIKMKLTLLKTIVALAQKSHI---RDKEFVWFVVRHSCRFSKPSQEH----GSQE 493
            ....| |.|:.:.::..|.:.||.:|...::   ..:.||.::||||   :....:|    |...
plant   404 TASSL-LDEQSLAVRKALSELIVVMASHCYLVGPSGELFVEYLVRHS---AIGESDHLKAKGELV 464

  Fly   494 EHANLVLSCENTLYMLASTVGTLD-------ELLKRE------LLNYLILLDYTDICGNLAKCLA 545
            ....|...|...|.:|..|:..::       |.:|.:      ||..:|...||....::.:|:.
plant   465 SPTQLRAVCGKGLLLLTVTIPEMELSDFNAKEYMKLQYILWPFLLKMIIPKVYTGAVASVCRCIT 529

  Fly   546 SLFAKSPHIEYDIAGDDAATEQATPESMGAAGEDRSVIKRGKVMVPGAETIYARCLALLGNQQCI 610
            .|..:              ....||..:..         :.:..:|..|.::.|.:.||.|....
plant   530 ELCRR--------------RSSTTPMLIEC---------KARADIPNPEELFTRLVVLLHNPLAK 571

  Fly   611 KR-CSNILSFLRYYHPQVNPALEELWERKIP----------DLLLQINRESAYRQLLHDFVLETN 664
            :: .|.||:.|.|..|.....:...|:.:||          ||.|....:..:..::.:|:.|:.
plant   572 EQLASQILTVLGYLSPLFPKNISMFWQDEIPKMKAYVYDTEDLKLDPTYQETWDDMIINFLAESL 636

  Fly   665 EFLGGLDENFAQRLASKLADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQVTDVACIHT 729
            :..  .|.::...|.:..|.|..||.....|:           .:|.:.:.:.|.:|.|.|.:..
plant   637 DVT--QDADWVISLGNSFAKQYILYAPDDDHA-----------ALLHRCIGILLQKVNDRAYVRD 688

  Fly   730 KIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGR---KHST 791
            |||.:     .|:.|..:.    ..|: ..|:|:|.::..||..:::||..:....|:   :...
plant   689 KIDWM-----YEQADISIP----ANRL-GLAKAMGLVAASHLDTVLEKLKIIVDNVGQSIFQRIL 743

  Fly   792 GFFSNLHFIKDT---HKEL-------------------------ENYKSNLLVVK---------- 818
            ..||..:..:|:   |..|                         .|..|.||.|:
plant   744 SLFSESYKTEDSDDIHAALALMYGYAAKYAPSSVIEARIDALVGTNMLSRLLHVRQQTAKQAVIT 808

  Fly   819 ---AFGRIMDEADPLQSIQHLDEDDTLLGFLIQQLAVHKDQTIMSAILQTL------LSICNQLI 874
               ..||.:..|....:...|...|.:|.:::..:...:::....:.|:.|      |:.|..|:
plant   809 AIDLLGRAVINAAETGATFPLKRRDQMLDYILTLMGRDENEGFAESSLEVLHTQALALNACTTLV 873

  Fly   875 ATKEQLPAPLRHRKQIMETV---FNIPIEAPFHDLPLLPTILKLGTDFIRIGGPDTEECVDGGVI 936
            :.:.:|....|:|  :|:..   |.:|.:......||:..::.|....:...|
plant   874 SVEPKLTIETRNR--VMKATLGFFALPNDPSDVISPLIDNLVTLLCAILLTSG------------ 924

  Fly   937 FEIACRNFFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATL------ 995
                                   ||.|:.  |:.|...|.||:..|.:.::.......:
plant   925 -----------------------EDGRSR--AEQLLHLLRQLDQYVSSPIDYQRKRGCVAVHEML 964

  Fly   996 ----DLIIGILEGWT-------------RDRNSEVRICASHVFNNTLDVYI-KSMKIGCEAPSKF 1042
                .|.:|   |:.             .||:.:..      |:|...|:: ...::.|
plant   965 LKFRKLCVG---GYCALGCSGDCPHRKYADRSMQGN------FSNLPSVFLFPDREVLC------ 1014

  Fly  1043 NQTGQMLGKIVPRCIDSNGTVRQVSVEILQKTLEIA-CIYETLTIASIDSTADW-----LKEIET 1101
              .|..:...:|||.|:|..||::|.:||.:...|: .:.:.:..:.:||...:     |:::..
plant  1015 --LGDRVITYLPRCADTNSEVRKISAQILDQFFSISLSLPKAVLTSGLDSEDSYKALSSLEDVIA 1077

  Fly  1102 IKEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTL--------LHS----LRDPEQSSTI 1154
            |.:...:.:|.:::|           ||.|    ..|..|        |||    :.|..:.|..
plant  1078 ILKSDASIDPSEVFN-----------RIVS----SICSLLTEHELVAALHSCTAAICDKIRQSAE 1127

  Fly  1155 GASVVLKFFIQQKGSELFHAIPDLVRDSLLA---------LRVCEVPRAKSGVLKALVALTKHHP 1210
            ||...:..|:.::||:|..........|||:         |||..:     |.:.||...|:  .
plant  1128 GAIQAVTEFVSRRGSQLSDNDISRTTHSLLSAAVHITDKNLRVEAI-----GAISALAENTQ--S 1185

  Fly  1211 KLVCAEMLSQ-----------------PLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASL 1258
            .:|..|:|:.                 |:.      :.::......||:.|.:::.:.:|:.:||
plant  1186 SIVFNEVLATAGKDIVTKDITRMRGGWPMQ------DAFYAFSQHTELSVLFMEHLISILNRSSL 1244

  Fly  1259 QEG----GQDASLSERQKLASGQPFAIFCALHEML--PCKDIKGQLETRFADMFCMLLTSLSSYT 1317
            .:.    |::.|.|....:......|...||....  ..|..|..:|..::.:...|...|.|..
plant  1245 VKSDSHKGENTSSSSETHVEDDILQAAIFALTAFFRGGGKIGKKAVEKSYSSVVGALTLQLGSCH 1309

  Fly  1318 NLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQIALETFQAF---LTNLEMEQIASVL 1379
            .||:               ||:.             :|.::.|.:||||   :.:|||   ..:|
plant  1310 GLAS---------------SGQQ-------------DPLRVLLTSFQAFCECVGDLEM---GKIL 1343

  Fly  1380 TVNTQLASSADWHNYIELLTPMAIGLGQQLQLGSP-QMRQLVNSLSKYVASPYDGQRVAAVGIFS 1443
            ..|.:......|   :.|:..:| |.   :.:..| ::|.:...|:|.:..|...||.||....|
plant  1344 ARNGEQIEKEKW---VGLIGDIA-GC---ISIKRPKEVRHICMILTKALNRPQRFQREAAAAALS 1401

  Fly  1444 RLVPLKPTGELAASILLHLGAAL----SDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALL 1504
            ..:  :.:|:. :|::..:..||    ||.:..||.|.::|:   .|:.......|:...||.:|
plant  1402 EFI--RYSGDF-SSVMEEMVEALCRHVSDDSPTVRRLCLRGL---VQMPSACMSHYTTQVIGVIL 1460

  Fly  1505 KGVDDPVGDCLINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFG 1569
            ..:|| :.:   ::.|.::..|..:..:..::.|||..::|::|:|....:...:||..|....|
plant  1461 ALLDD-LDE---SVQLTAVSCLLMVTESASNDAVEPILLNLSVRLRNLQVSMDPKMRANAFSALG 1521

  Fly  1570 DICEGKHDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQRVCRLLTAPRVVE 1634
            .:  .|:..|     ...|...||:.:.|..|::||.:.:.:|..|||.||:|...|:.......
plant  1522 AL--SKYATG-----GQREGFVEQIHSTLPRLVVHLHDDDPSIRQACRVTLKRFAPLVDIINYST 1579

  Fly  1635 MAEQQ-LGEERGHQLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIGIL 1698
            :.:.: .|.|  .:.:|.:||.:..|.:..| ::.:..::.|.:....:.||.::.:|......:
plant  1580 LYDSRAFGSE--DRTDYENFVRDLSKHLVQE-SERVDTYMASTIQAFDAPWPVIQANAIHFSTTM 1641

  Fly  1699 HNFLSERNVQT-------ETVASKIAVLLKDEQALVRMRAATALG 1736
            .:...::::.:       ||:.||   :.:.:.::||...::|.|
plant  1642 LSLSEDQHIISLYYPQVFETLVSK---MTRSQDSVVRAACSSAFG 1683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_001285050.1	None
AT2G36810	NP_181219.4	HEAT repeat	1417..1445	CDD:293787	9/30 (30%)
		HEAT repeat	1454..1484	CDD:293787	7/33 (21%)
		HEAT repeat	1493..1522	CDD:293787	6/28 (21%)
		HEAT repeat	1539..1568	CDD:293787	10/28 (36%)
		HEAT repeat	1600..1646	CDD:293787	6/46 (13%)
		HEAT repeat	1655..1680	CDD:293787	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I992
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I1411
OMA	1	1.010	-	-		QHG54925
OrthoDB	1	1.010	-	-		D31329at2759
OrthoFinder	1	1.000	-	-		FOG0005807
OrthoInspector	1	1.000	-	-		oto2901
orthoMCL	1	0.900	-	-		OOG6_105368
Panther	1	1.100	-	-	LDO	PTHR23120
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840