DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c11.1 and mroh1

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	XP_017207004.1	Gene:	mroh1 / 794708	ZFINID:	ZDB-GENE-090806-2	Length:	1651	Species:	Danio rerio

Alignment Length:	1795	Identity:	441/1795 - (24%)
Similarity:	794/1795 - (44%)	Gaps:	256/1795 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TILEGVLHNIFDGLMDKEEQVRIAMQQAIVKILETHPERAAEILSEHRSQQPKMTDQTVAMLLDC 113
            |.:|.|...:.|...|::..|:..::::|:.:....|::...:..::..:.||:......::|..
Zfish     7 TDIEQVTLALLDAANDRDPVVQEQVRKSILTLGNQKPDKVLSMCQDYLLKHPKLVVGHRVVVLQT 71

  Fly   114 IRRVVGA---ETPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRILVAIGRSSPESCEQVMEA 175
            |..||.:   :...|..  :.:|.||..|:|::.|.:|..|..|..||||:|.   :....:||.
Zfish    72 IELVVKSRIDDITYPKI--KSVIQLASDEMTRSKEVVPDWQQAASNILVAVGN---KYINDIMEE 131

  Fly   176 LQEKGTSTEGV-AHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGR 239
            :..|  ...|| .||.::|.|..|:..|..|:||.:.||:....|.|...:.|::|...:.|:.|
Zfish   132 ILSK--FQPGVLPHFFVVQTLANLSDSNVYGMVPFLNAIMGTMLPMLGMTKHDNMKWVFSSALCR 194

  Fly   240 FSEALLEESGKKE--------EENCSTEISVAYDVLFNQWLHSREPKVCVEILQALSSMYPLLPK 296
            |||::||.....:        ::..|:||..|||:|||.|:.|||.|:.:.:.:||.||..|:..
Zfish   195 FSESILEYLANLDKAPDPTVRKDTFSSEIFSAYDILFNSWIQSREAKLRLTVAEALGSMSHLMAH 259

  Fly   297 DRIQDQAARLVPQILALYRRSVDRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLVCVYP 361
            |::::|..:|:|.||.||:::.:...:::.||.||:.::.:.:.||:..||.|:..|...||...
Zfish   260 DKLEEQLPKLLPTILGLYKKNTEHYIISKSLCQVLEASVNMGSRVLETQIDGLLLALHQQVCSPV 324

  Fly   362 DYEKPQTVKGHYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNI 426
            |:..|.|:|.|.||||||.:||...|  .|:|..:|..|.|::||.||.||.:|.||:||....:
Zfish   325 DFSNPPTIKNHNEVLRCFSILANTFP--DRLMVFVLQRLENSNERNRMGSLAVLRHLINSSTSTM 387

  Fly   427 ENRIPATIECLKQLILSERGIKMKLTLLKTIVALAQKSHIR---DKEFVWFVVRHSCRFSKPSQE 488
            |.:....:..::| .|::...|:|..:::.|.|:|...::.   ....|.|:::| |  :.|...
Zfish   388 ETKKLLILASIRQ-PLADHSNKVKKRVVQVISAMAHHGYLELDGGDLLVRFIIQH-C--ALPDTY 448

  Fly   489 HGSQ-----EEHANLVL--SCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKCLAS 546
            :..|     ||..|..|  .|:|||::..:|||.|.::|...||.||....|.:....|.|.|..
Zfish   449 YKGQRPQDPEEVTNEALRSMCDNTLHLFTTTVGRLTDVLWPMLLCYLTPNQYANATTPLCKSLIL 513

  Fly   547 LFAKSPHIEYDIAGDDAATEQATPESM---GAAGEDRSVIKRGKVMVPGAETIYARCLALLGNQQ 608
            |           |....||::  |..|   .|.|..          :|..   |...:.||.|..
Zfish   514 L-----------ANKKRATQE--PNFMIDFNAQGSS----------LPSQ---YILLIRLLVNAS 552

  Fly   609 CIKRC----SNILSFLRYYHPQVNPALEELWERKIPDLLLQINRESAYRQLLHDFVLETNEFLGG 669
            ...|.    :..||.|....|.::|..|.|||.:||.||       :|.:...:..|:..::
Zfish   553 FPFRYRGHGAPSLSLLNAISPSIHPKAETLWENEIPKLL-------SYLEESTEDSLDKKKW--- 607

  Fly   670 LDENFAQRLASKLADQMYLYPMQLPHSEW----------HLPDLS---AERGMLLQAVALTLLQV 721
             ||...|.|:..||        .:..|.|          :||..:   .|:..|.:.|.:.|.|.
Zfish   608 -DETLLQLLSKTLA--------TIDDSRWTNQLAVEATRYLPTYNNSLEEKSFLYRCVGVILQQC 663

  Fly   722 TDVACIHTKIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGG 786
            .:...:..::..|:...|         |.|..:| ...|..:|..:..||...::||.|..:...
Zfish   664 YNKELVRKQLQEILINTR---------HNDAVER-TGVAMGIGLCASSHLDGTLEKLEEFGKSDA 718

  Fly   787 RKHSTGFFSNLHFIKDTHK-ELENYKSNLLVVKAFGRIMDEADPLQSIQHLDED----------D 840
            .:.::|.|.   .:||.:. ::|..||.|::  .:|.:...|...|.:..:|.|          .
Zfish   719 FRKASGIFG---LLKDKNDVDVEKMKSTLIL--CYGYVALHAPEDQLLTRIDSDILQNISKNFNT 778

  Fly   841 TLLGFLIQQLAVHKDQTIMSAILQT------------------------LLSICNQLIATK--EQ 879
            .:||..::.    ||.|:..:::.:                        |:.:....|..:  |.
Zfish   779 KVLGIKVET----KDLTMKLSLIHSVGLIAKAISNSVRKQGFMFTRKHELMGVMTDFIKAEPPEV 839

  Fly   880 LPAPLRHRKQIMETVFN-IPIEAPF---HDLPLLPTILKLGTDFIRIGGPDTEECVDGGVIFEIA 940
            :..|:|:  .::.|..| |.::.|.   .:..||.|.|.      .:.|..|.:..|.|...|
Zfish   840 MRTPVRY--LVLTTCANLINLDPPLTENENFDLLKTCLN------GVYGLPTADTPDKGKDEE-- 894

  Fly   941 CRNFFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATLDLIIGILEGW 1005
                         ..|.|:.:...|       ::...|:.|:|.::..|.||..|..:...:|.|
Zfish   895 -------------ALDPQQREVLYS-------DTFNALHELLRNVLARDLSPDGLQAVFKHIESW 939

  Fly  1006 TRDRNSEVRICASHVFNNTLDVYIKSMKIGCEAPSKFNQTGQMLGKIVPRCIDSNGTVRQVSVEI 1070
            ........|..|.....:.|..|:.::.:  :....|:..|.::|::.|||.|.|..||:.:::.
Zfish   940 LSSGQDHERERAVKTTAHLLQFYLDNLSV--KNLVTFHNLGALVGRLAPRCTDPNPEVRRAAIDC 1002

  Fly  1071 LQKTLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQIYNLAGDIAKIIALRISSFQYL 1135
            :...:.|...||..   |:|...|.::.:..::|.:...:...:|....::.|||:.|:...|..
Zfish  1003 IYSLMYIQLRYEGF---SLDYKDDSVEALLDVREKLSNPDHSVLYKTCSELTKIISKRLPQQQLS 1064

  Fly  1136 QFCKTLLHSLRDPEQSSTIGASVVLKFFIQQKGSELFHAIPDLVRDSLLALRVCEVPRAKSGVLK 1200
            .....|...|.|.:.:.:..:||:|...::.:|:.|...:|:::......|:|....:.|..:.:
Zfish  1065 TLLFMLFDGLVDSQSNCSRASSVILNTLLKNRGAGLQDLVPEMLEVLHNRLQVIGEEQVKVAIGQ 1129

  Fly  1201 ALVALTKHHPKLVCAEMLSQPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLS---------GA 1256
            :::.|...|.:.|...:::.|||||....|.|..:..|..|....::..::.|:         .:
Zfish  1130 SILILATQHLQTVVNTLVAYPLPYDSWSCEMWMALGADSTLALQIMEMIIEKLNVMVPYVDKKES 1194

  Fly  1257 SLQEGGQDASLSERQKLASGQPFAIFCALHEMLPCKDIKGQLETRFA----DMFCMLLTSLSSYT 1317
            .|:.|        ..|:|:..|.|:.|||.||:    :.||.....|    .:|..||..|.|..
Zfish  1195 MLRPG--------LTKVATSHPLAMTCALREMM----LNGQSADAVAHLLPKLFSALLVRLGSSV 1247

  Fly  1318 NLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQIALETFQAFLTNLEMEQIASVLTVN 1382
            .:..|..:|:.|:..::..:.|        ..:|..:.|.:|:|..:..|...:::.:...|...
Zfish  1248 GVQLPKDLNSNSIISDRKATNK--------NSVINFDVCGVAVEALRVLLARAQLDAVVKPLDQE 1304

  Fly  1383 TQLASSADWHNYIELLTPMAIGLGQQLQLGSPQMRQLVNSLSKYVASPYDGQRVAAVGIFSRLVP 1447
            .......|...:...:|.::..:.:.   ..|::..:|.||...:.:.|:.||:......|.|:.
Zfish  1305 GAWDKMKDPQQHTTGVTLLSRAMAKH---AGPRLPAIVESLCPSLCNIYECQRITVTAFLSELLN 1366

  Fly  1448 LKPTGELAASILL--HLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGV--- 1507
            .....||....:|  ::...::|....||.|:::|:|.:.....::..:|::..:.|:..|:
Zfish  1367 HHVATELMILDMLMNNMMERITDTCGTVRMLAVRGLGNIAVGSPEKVNKYAKELLAAMSSGMEEK 1431

  Fly  1508 DDPVGDCLINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDIC 1572
            ||| |..   |.||:|.|:|.||..|..:.|....|.:.::|:|||.|...|:|.|:|.|.|::.
Zfish  1432 DDP-GKL---ITLEAMSGMSKILLYLDQKNVNLLVVYIFMKIKPFLENENDEIRCASIMLLGNLS 1492

  Fly  1573 EGKHDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQRVCR-LLTAPRVVEMA 1636
            :    .||..|     ..::|:...|..||||||:....:..||:..: |:|. ::.:.::..|.
Zfish  1493 K----FGSGEP-----VFKDQIHNVLVSLLLHLSDPNPHVVKACKYAM-RICAPVVGSEQISAMF 1547

  Fly  1637 EQQLGEERGHQLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIGILHNF 1701
            :..|.||:|  |:|..|:.:..|.:..:....:..:..:.:...:|.|.|:|.|||:.||.|...
Zfish  1548 QNHLLEEKG--LHYGEFINDLTKYLIQDFPGMLNFYHITVVQFFKSNWAEIRASAAMFIGFLLGN 1610

  Fly  1702 LSER---NVQTETVASKIAVLLKDEQALVRMRAATALGYF 1738
            |.:.   ::...:|...:.:||:|...|||::||.|:|:|
Zfish  1611 LPDEHFSHMNMGSVTKGLVMLLQDPDPLVRVKAAEAMGHF 1650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_001285050.1	None
mroh1	XP_017207004.1	HEAT repeat	1376..1404	CDD:293787	6/27 (22%)
		HEAT repeat	1421..1445	CDD:293787	10/27 (37%)
		HEAT repeat	1457..1493	CDD:293787	13/35 (37%)
		HEAT repeat	1504..1537	CDD:293787	12/33 (36%)
		HEAT repeat	1546..1610	CDD:293787	19/65 (29%)
		HEAT repeat	1621..1650	CDD:293787	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2124
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44882
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1601
OMA	1	1.010	-	-		QHG54925
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	1	1.000	-	-		FOG0005807
OrthoInspector	1	1.000	-	-		otm24361
orthoMCL	1	0.900	-	-		OOG6_105368
Panther	1	1.100	-	-	LDO	PTHR23120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5822
SonicParanoid	1	1.000	-	-		X3684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870