Protein Alignment c11.1 and MROH1

DIOPT Version :9

• Sequence 1: NP_001285050.1
• Gene: c11.1 / 53436
• FlyBaseID: FBgn0040236
• Length: 1742
• Species: Drosophila melanogaster
• Sequence 2: XP_024303020.1
• Gene: MROH1 / 727957
• HGNCID: 26958
• Length: 1764
• Species: Homo sapiens
• Alignment Length: 1841
• Identity: 425/1841 - (23%)
• Similarity: 767/1841 - (41%)
• Gaps: 297/1841 - (16%)

  Fly     1 MDGRGVGGGGSGAATGGGSANNKSAAGNSAATGNADASTATAAPNDKPTILEGVLHNIFDG---- 61
            |.|..|.|   .|..|...|:..||  ...|.|::....||..|..:.::|......::||
Human    21 MTGHSVPG---IALAGPPGASPHSA--KPPAEGHSQLLQATCIPCLRASLLHPPSQQLWDGRRSC 80

  Fly    62 -----------------------------LMDKEEQVRIAMQQAIVKILETHPERAAEILSEHRS 97
                                         :.||:..|:..:..|:..:.|..|........|:..
Human    81 PCSHWVKEAETTDMTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLR 145

  Fly    98 QQPKMTDQTVAMLLDCIRRVVGAE-TPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRILVAI 161
            |..|:.....|.:|..:.||:.:. :.|.......:|.||..|:||..:.:...|..|..:|||:
Human   146 QHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDLVWDWQQAASGVLVAV 210

  Fly   162 GRSSPESCEQVMEALQEK---GTSTEGVAHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVG 223
            ||   :...:|||.|..:   ||    :.|..::..|..|:..|..||||.:.::||...|.|..
Human   211 GR---QFISKVMEELLRRLHPGT----LPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGV 268

  Fly   224 IRQDHIKQAHAYAIGRFSEALLEESGKKE--------EENCSTEISVAYDVLFNQWLHSREPKVC 280
            .:||.::.|...|:.||||..||.....:        ::..:|:|..||||||:|||.|||.|:.
Human   269 AKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLR 333

  Fly   281 VEILQALSSMYPLLPKDRIQDQAARLVPQILALYRRSVDRNAVTQFLCSVLKTNLALNATVLDGI 345
            :.:::||..|..|||.:|:::|..:|:|.|||||::..:...:::.|..:|:..:::.:..|:..
Human   334 LAVVEALGPMSHLLPSERLEEQLPKLLPGILALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQ 398

  Fly   346 IDVLVTHLFDLVCVYPDYEKPQTVKGHYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMK 410
            :|.|:..|...:||..:...|..:....||||||.:||...|  .|::..||..|..::||.|:.
Human   399 LDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSP--DRLLAFLLPRLDTSNERTRVG 461

  Fly   411 SLLILTHLLNSCAGNIENRIPATIECLKQLILSERGIKMKLTLLKTIVALAQKSHIRD---KEFV 472
            :|.::.|::||.|..:|::.|..:..:: |.|.:...|:|..:::.|.|:|...::..   :..:
Human   462 TLQVVRHVINSAAAQMEDKKPFILSSMR-LPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMI 525

  Fly   473 WFVVRHSCRFSKPSQE-----HGSQEEHANLVLSCE-NTLYMLASTVGTLDELLKRELLNYLILL 531
            .::|: .|.. .|.||     .||::..|:.|.:.. .|||::::||..:..:|...||.:|..:
Human   526 EYIVQ-QCAL-PPEQEPEKPGPGSKDPKADSVRAISVRTLYLVSTTVDRMSHVLWPYLLQFLTPV 588

  Fly   532 DYTDICGNLAKCLASLFAKSPHIEYDIAGDDAATEQATPESMGAAGEDRSVIK-RGKVMVPGAET 595
            .:|.....|.:.|..|..|...                      ||.|..:|: .....:|....
Human   589 RFTGALTPLCRSLVHLAQKRQE----------------------AGADAFLIQYDAHASLPSPYA 631

  Fly   596 IYARCLAL-----LGNQQCIKRCSNILSFLRYYHPQVNPALEELWERKIPDLLLQINR------- 648
            :..|.|.:     ||:    .|.:..|..|...||.::|.|.:.||..:|.||..::.
Human   632 VTGRLLVVSSSPYLGD----GRGAAALRLLSVLHPNIHPLLGQHWETTVPLLLGYLDEHTEETLP 692

  Fly   649 ESAYRQLLHDFVLETNEFLGGLDENFAQRLASKLADQMYLYPMQLPHSEWHLPDLSAERGMLLQA 713
            :..:.:.|..|:.:|...:.  |..:..:|:.:|..|:..|           .:...|:..|.:.
Human   693 QEEWEEKLLMFLRDTLAIIS--DNAWICQLSLELCRQLPCY-----------DEAPQEKNFLYKC 744

  Fly   714 VALTLLQVTDVACIHTKIDLIVTTAR-QERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKK 777
            :..||...:....:...:..::.||| ||..::           |..|...|..:..||...:.:
Human   745 IGTTLGAASSKEVVRKHLQELLETARYQEEAER-----------EGLACCFGICAISHLEDTLAQ 798

  Fly   778 LTELAQVGGRKHSTGFFSNLHFIKD-THKELENYKSNLLVVKAFGRIMD-----------EADPL 830
            |.:..:....:.|.|.   |:..|| :..|:|..||.|::  .:|.:..           |:|.|
Human   799 LEDFVRSEVFRKSIGI---LNIFKDRSENEVEKVKSALIL--CYGHVAARAPRELVLAKVESDIL 858

  Fly   831 QSI-QHLDEDDTLLGFLIQQLAVHKDQTIMSAILQTLL----SICNQLIA------TKEQLPAPL 884
            ::| ||.  ...:||..::.    ||..:...::|::.    :||:...|      .|.:|.|
Human   859 RNICQHF--STKVLGIKVET----KDPALKLCLVQSVCMVSRAICSSTQAGSFHFTRKAELVA-- 915

  Fly   885 RHRKQIMETVFNIP---IEAPFHDLPLLPTILKLGTDFIRIGGPDTEECVDGGVIFEIACRNFFG 946
                |:||.:...|   :..|.....:|.....:..:      |..:|.....||        .|
Human   916 ----QMMEFIRAEPPDSLRTPIRKKAMLTCTYLVSVE------PALDEQARADVI--------HG 962

  Fly   947 CAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATLDLIIGILEGWTRDRNS 1011
            |...:.......:|::.....:.:| |:|..|..|:.::::.:.:|..|.::|..|..|.:....
Human   963 CLHSIMALLPEPKEEDGGCQKSLYL-ETLHALEDLLTSLLQRNMTPQGLQIMIEHLSPWIKSPRG 1026

  Fly  1012 EVRICASHVFNNTLDVYIKSMKIGCEAPSKFNQTGQMLGKIVPRCIDSNGTVRQVSVEILQKTLE 1076
            ..|..|..:....|..:::.:::....|  |:..|.::|...|||.|.....||.:|:.:...|.
Human  1027 HERARALGLSALLLRYFLEHLRVSALVP--FHNLGLLIGLFSPRCADLWPATRQEAVDCVYSLLY 1089

  Fly  1077 IACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTL 1141
            :...||..   |.|...|..:.:.::|:.::..:|..:::....:.:|||.|:...|.:....|:
Human  1090 LQLGYEGF---SRDYRDDVAERLLSLKDGLVHPDPAILFHTCHSVGQIIAKRLPPDQLISLLLTM 1151

  Fly  1142 LHSLRDPEQSSTIGASVVLKFFIQQKGSELFHAIPDLVRDSLLALRVCE------VPRAKSGVLK 1200
            ..:|.|||::.:..|:|::...:|::|..|...:|::|  |:|..::.|      :|.|:..|
Human  1152 FEALGDPEKNCSRAATVMINCLLQERGGVLQEKVPEIV--SVLRSKLQEAQGEHVLPAAQHSV-- 1212

  Fly  1201 ALVALTKHHPKLVCAEMLSQPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDA 1265
              ..|...|...|.:.:|..|||.|.:....|..:..:|.|....|        |..|::..:|.
Human  1213 --YLLATQHCAAVVSSLLGSPLPLDSHTCMLWRALAVEPRLAAQVL--------GLLLEKMSRDV 1267

  Fly  1266 SLSERQKLASGQ---------PFAIFCALHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAA 1321
            ...|.:....|:         |.:..|||.|::........:...:..:|.:||..:|....:..
Human  1268 PFKESRAFLLGRTPDRVATLLPLSATCALFEVMSTPAAGPAVLELYPQLFVVLLLRVSCTVGVQL 1332

  Fly  1322 PNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQIALETFQAFLTNLEMEQIASVLTV--NTQ 1384
            |..:        |.|..:   |..|......|.||..|::|.::.|.....|.:...:.:  ..:
Human  1333 PRNL--------QAQERR---GASPALATRNLEPCSSAVDTLRSMLLRSGSEDVVQRMDLEGGWE 1386

  Fly  1385 LASSADWHNYIELLTPMAIGLGQQLQLGSPQMRQLVNSLSKYVASPYDGQRVAAVGIFSRLVPLK 1449
            |..::..|.  |..|.:|..:.:.   ..|::..::.:|:...:|.|:.|||......:.|:...
Human  1387 LLRTSAGHE--EGATRLARAMAEH---AGPRLPLVLKTLACTHSSAYENQRVTTTAFLAELLNSN 1446

  Fly  1450 PTGELAA--SILLHLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVG 1512
            ...:|..  |:|..|.|...|..|.||.|.::|:..:......:.:.:....:.|::.|:||  |
Human  1447 VANDLMLLDSLLESLAARQKDTCASVRRLVLRGLANLASGCPDKVRTHGPQLLTAMIGGLDD--G 1509

  Fly  1513 DCLIN----IPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDICE 1573
            |   |    :.||:|.||:.::..:.|..:....:.:|||||||..:..:|..:         .:
Human  1510 D---NPHSPVALEAMLGLARLVHLVESWDLRSGLLHVAIRIRPFFDSVTVESAD---------LQ 1562

  Fly  1574 GKHDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIAS-------------ACRGTLQ---- 1621
            |....|..||.....:....|.|:|..|....:|: |..:|             .|| ||:
Human  1563 GCCFAGPGSPHPRRWSSGRHLSASLGTLTRSATET-VRTSSWTRWWAGWRPCCCTCR-TLRPPWP 1625

  Fly  1622 ----RVCRLLTAPRVVEMAEQQLGEERGHQLNYSSFVLEFVKTIALELTDHIQD----FIDSCLP 1678
                |:|....|...:..|.|:..:| |..|::.    ||:.|....|..|..|    .:.:||.
Human  1626 AFALRMCGPNLACEELSAAFQKHLQE-GRALHFG----EFLNTTCKHLMHHFPDLLGRLLTTCLF 1685

  Fly  1679 QLRSQWPEVRGSAAIVIGILH 1699
            ..:|.|..||.:|.:..|..|
Human  1686 YFKSSWENVRAAAPLFTGKHH 1706

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I795
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44882
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1917
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54925
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	1	1.000	-	-		FOG0005807
OrthoInspector	1	1.000	-	-		otm41881
orthoMCL	1	0.900	-	-		OOG6_105368
Panther	1	1.100	-	-	O	PTHR23120
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5822
SonicParanoid	1	1.000	-	-		X3684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010