DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment c11.1 and MROH6

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	XP_011515516.1	Gene:	MROH6 / 642475	HGNCID:	27814	Length:	774	Species:	Homo sapiens

Alignment Length:	503	Identity:	124/503 - (24%)
Similarity:	189/503 - (37%)	Gaps:	102/503 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1151 SSTIGASVVLKFFIQQKGSELFHAIPDLVRDSLLALRVCEVPRAKSG-----VLKALVALTKHHP 1210
            :.|....:.|...::.:|..|...:..||| .|||    :||....|     .|:.|.||...|.
Human   126 AGTQATVLTLSSALEARGERLEDQVHALVR-GLLA----QVPSLAEGRPWRAALRVLSALALEHA 185

  Fly  1211 KLVCAEMLSQPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLAS 1275
            :.|...:|.:.||.|....|.|..:..:..:.|..|...|..|.|||    |     .|.|.||:
Human   186 RDVVCALLPRSLPADRVAAELWRSLSRNQRVNGQVLVQLLWALKGAS----G-----PEPQALAA 241

  Fly  1276 GQPFAIFCALHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKT 1340
            .:      ||.|||......|.....:..:...|:|.|         :.:..:..||:..:....
Human   242 TR------ALGEMLAVSGCVGATRGFYPHLLLALVTQL---------HKLARSPCSPDMPKIWVL 291

  Fly  1341 KFGFVPNKELIKLNPCQIALETFQAFLTN-------LEMEQ-------------IASVLTVNTQL 1385
            .....|:..      ...|:|..:|.||.       ..|||             :..||.:.:.:
Human   292 SHRGPPHSH------ASCAVEALKALLTGDGGRMVVTCMEQAGGWRRLVGAHTHLEGVLLLASAM 350

  Fly  1386 ASSADWHNYIELLTPMAIGLGQQLQLGSPQMRQLVNSLSKYVASPYDGQRVAAVGIFSRLVPLKP 1450
            .:.||.|                       :|.|...|...:.|..|.||:.|:..|:.|:..:|
Human   351 VAHADHH-----------------------LRGLFADLLPRLRSADDPQRLTAMAFFTGLLQSRP 392

  Fly  1451 TGELAAS--ILLHLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGD 1513
            |..|...  ||..|.....||...||.|.:.|:|::. |..::..|:..|.:.|||..:.:  ||
Human   393 TARLLREEVILERLLTWQGDPEPTVRWLGLLGLGHLA-LNRRKQVRHVSTLLPALLGALGE--GD 454

  Fly  1514 C-LINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDIC---EG 1574
            . |:...|.::|.|  :||  |...|......|..|:.|.|.:....:|.:|:.|.|.:.   .|
Human   455 ARLVGAALGALRRL--LLR--PRAPVRLLSAELGPRLPPLLDDTRDSIRASAVGLLGTLVRRGRG 515

  Fly  1575 KHDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQR 1622
            ....|...|      ||:.::.:|.||||.|.:.....|.:...||.|
Human   516 GLRLGLRGP------LRKLVLQSLVPLLLRLHDPSRDAAESSEWTLAR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
c11.1	NP_001285050.1	None
MROH6	XP_011515516.1	PHA03247	<637..741	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23120
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000