DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c11.1 and MROH5

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	NP_997297.2	Gene:	MROH5 / 389690	HGNCID:	42976	Length:	1318	Species:	Homo sapiens

Alignment Length:	1468	Identity:	289/1468 - (19%)
Similarity:	516/1468 - (35%)	Gaps:	423/1468 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 RFSKPSQ--EHGSQEEHANLVLSCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKC 543
            |:|.|:.  .|.||...|.|:|. |:.::|..:                     |:...|  .|.
Human    53 RWSHPTTILLHKSQSSQATLMLQ-EHRMFMGEA---------------------YSAATG--FKM 93

  Fly   544 LASLFAKSP-HIEYDIAGDDAATEQATPESMGAAGEDRSVIKRGKVMVPGA-----ETIY----- 597
            |..:.:..| |::|                         :||:.|.|..|:     |||:
Human    94 LQDMNSADPFHLKY-------------------------IIKKIKNMAHGSPKLVMETIHDYFID 133

  Fly   598 ------ARCLALLGNQQCIKRCSNIL------SFLRYYHPQVNPA--LEELWERKIPDLLLQINR 648
                  .....|....:.:...|::|      :|.|.....:..|  ||::::....::|:.|.|
Human   134 NPEISSRHKFRLFQTLEMVIGASDVLEETWEKTFTRLALENMTKATELEDIYQDAASNMLVAICR 198

  Fly   649 ESAYR--------QLL-----HDFVLETNEFLGGLDENFAQR-------------------LASK 681
            .| :|        :||     |..:|.....|...:|.|:|.                   |::.
Human   199 HS-WRVVAQHLETELLTGVFPHRSLLYVMGVLSSSEELFSQEDKACWEEQLIQMAIKSVPFLSTD 262

  Fly   682 LADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQVTDVACIHTKIDLIVTTARQERLDKH 746
            :..:..|:.:..|  .|...:.|.|:..|.....|.|....:.|.:...:..::.|:.|
Human   263 VWSKELLWTLTTP--SWTQQEQSPEKAFLFTYYGLILQAEKNGATVRRHLQALLETSHQ------ 319

  Fly   747 VKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGRKHSTGFFSNLHFIKDTHKELENYK 811
                 :.|:.|..|..||..:.:||..:...|.:.    ||.....:  :|......:.|...:|
Human   320 -----WPKQREGMALTLGLAATRHLDDVWAVLDQF----GRSRPIRW--SLPSSSPKNSEDLRWK 373

  Fly   812 -SNLLVVKAFGRIMDEA--------DPLQS-----IQHLDEDDT-----------LLGFLIQQLA 851
             ::..::.|:|::..:|        |.:.|     ..:...|:|           |:|.:.:...
Human   374 WASSTILLAYGQVAAKARAHILPWVDNIVSRMVFYFHYSSWDETLKQSFLTATLMLMGAVSRSEG 438

  Fly   852 VHKDQTIM-SAILQTLL---------SICNQL------IAT---KEQLPAPLRHRKQIMETVFNI 897
            .|..:... |.:||.|:         ::|.:.      ||:   |.:.|..|..:.|::.|.|.
Human   439 AHSYEFFQTSELLQCLMVLMEKEPQDTLCTRSRQQAMHIASSLCKLRPPIDLERKSQLLSTCFR- 502

  Fly   898 PIEAPFHDLPLLPTILKLGTDFI-------------RIG------GPDTEECVDGGVIFEIACRN 943
                ....||||..:.|....|:             |.|      ||                |.
Human   503 ----SVFALPLLDALEKHTCLFLEPPNIQLWPVARERAGWTHQGWGP----------------RA 547

  Fly   944 FFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATLDLIIGILEGWTRD 1008
            ...|::.|:..:                :.::..|:.::::::..:.:...|..::..|..|...
Human   548 VLHCSEHLQSLY----------------SRTMEALDFMLQSLIMQNPTADELHFLLSHLYIWLAS 596

  Fly  1009 RNSEVRICASHV---------FNNTLDVYIKSMKIGCEAPSK-FNQTGQMLGKIVPRCIDSNGTV 1063
            ..:..|..|.|.         .|..||            |.: |.:.||::|.:...|.|.:...
Human   597 EKAHERQRAVHSCMILLKFLNHNGYLD------------PKEDFKRIGQLVGILGMLCQDPDRAT 649

  Fly  1064 RQVSVEILQKTLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQIYNLAGD-------- 1120
            ::.|:|......::...::|......:|.|                 ||::.....|
Human   650 QRCSLEGASHLYQLLMCHKTGEALQAESQA-----------------PKELSQAHSDGAPLWNSR 697

  Fly  1121 -----------IAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTI----------------GASV 1158
                       :||....::.|||.:   |.::..|...|.|..|                .||.
Human   698 DQKATPLGPQEMAKNHIFQLCSFQVI---KDIMQQLTLAELSDLIWTAIDGLGSTSPFRVQAASE 759

  Fly  1159 VLKFFIQQKGS--ELFHAIPDLVRDSLLALRVCEV--PRAKSGVLKALVALTKHHPKLVCAEMLS 1219
            :|...:|:.|:  |:..::...:|     ||:|.|  |:||...|.|:..|.:.|...:.|..|:
Human   760 MLLTAVQEHGAKLEIVSSMAQAIR-----LRLCSVHIPQAKEKTLHAITLLARSHTCELVATFLN 819

  Fly  1220 QPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQPFAIFCA 1284
            ..:|.|.:..:.|..:......:.|.|...|..|....|..|..|:|...::|... :..|....
Human   820 ISIPLDSHTFQLWRALGAGQPTSHLVLTTLLACLQERPLPTGASDSSPCPKEKTYL-RLLAAMNM 883

  Fly  1285 LHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKE 1349
            |||:...::.|..::..:..:|..|||.:.....|..|:       .|...|..:.  ..||:.:
Human   884 LHELQFAREFKQAVQEGYPKLFLALLTQMHYVLELNLPS-------EPQPKQQAQE--AAVPSPQ 939

  Fly  1350 LIKLNPCQIALETFQAFLTNLEMEQIASVLTVNTQLASSADWHNYI--------ELLT-----PM 1401
                 .|..:||..::.                  |:::..||::.        ||.|     |.
Human   940 -----SCSTSLEALKSL------------------LSTTGHWHDFAHLELQGSWELFTTIHTYPK 981

  Fly  1402 AIGLGQQLQLGS------PQMRQLVNSLSKYVASPYDGQRVAAVGIFSRL----VPLKPTGELAA 1456
            .:||..:..:.:      ..:|||:.||.    ||.:.:|..|:.|.::.    |.|:...:.||
Human   982 GVGLLARAMVQNHCRQIPAVLRQLLPSLQ----SPQERERKVAILILTKFLYSPVLLEVLPKQAA 1042

  Fly  1457 SILLHLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGD-------- 1513
            ..:|..|  |.||:..||.||:||:..:....:|          |:||:|...|:.|
Human  1043 LTVLAQG--LHDPSPEVRVLSLQGLSNILFHPDK----------GSLLQGQLRPLLDGFFQSSDQ 1095

  Fly  1514 ---CLINIPLESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDICEGK 1575
               |:       |..:|..|..|.::......:.:||..|.|..:....:|.||:.||||:....
Human  1096 VIVCI-------MGTVSDTLHRLGAQGTGSQSLGVAISTRSFFNDERDGIRAAAMALFGDLVAAM 1153

  Fly  1576 HDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQRVCRLLTAPRVVEMAEQQL 1640
            .|       ..:..||.|:..::.||||||.:...|:|:..:.|..| |.:|...|::......|
Human  1154 AD-------RELSGLRTQVHQSMVPLLLHLKDQCPAVATQAKFTFYR-CAVLLRWRLLHTLFCTL 1210

  Fly  1641 GEERGHQLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIG--ILHN--- 1700
            ..|||  |:...|:...:.|.:.|   .....:...|..|.|....::....:.||  |.::
Human  1211 AWERG--LSARHFLWTCLMTRSQE---EFSIHLSQALSYLHSHSCHIKTWVTLFIGHTICYHPQA 1270

  Fly  1701 -FLSERNVQTETVASKIAVLLKDEQALVRMRAATALGY 1737
             |.....|.|..:......|..|.:..:|..|.:.|.:
Human  1271 VFQMLNAVDTNLLFRTFEHLRSDPEPSIREFATSQLSF 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
c11.1	NP_001285050.1	None
MROH5	NP_997297.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		HEAT 1	581..618	6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..695	5/35 (14%)
		HEAT 2	769..811	14/46 (30%)
		HEAT 3	840..880	9/40 (23%)
		HEAT 4	996..1033	10/40 (25%)
		HEAT 5	1037..1074	13/38 (34%)
		HEAT 6	1076..1113	10/43 (23%)
		HEAT 7	1118..1155	11/36 (31%)
		HEAT 8	1164..1200	13/36 (36%)
		HEAT 9	1278..1315	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23120
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100