DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c11.1 and MROH7

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	NP_001034553.3	Gene:	MROH7 / 374977	HGNCID:	24802	Length:	1323	Species:	Homo sapiens

Alignment Length:	927	Identity:	183/927 - (19%)
Similarity:	346/927 - (37%)	Gaps:	185/927 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   823 IMDEADPLQSIQHL----DEDDTLLGFLIQQLAVHKDQTIMSAILQTLLSICNQLIATKEQLPAP 883
            :::....||..|.|    .|..|::..:::|:......::.|::.:..:.|..||..|:..|  .
Human   435 LVENVTTLQKSQDLLEAEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEILTQLSHTQPTL--G 497

  Fly   884 LRHRKQIMETVFNIPIEAPFHDLPLLPTILKLGTDFIRIGGPDTEECVDGGVIFEIACRNFFGCA 948
            :|.|.:::    |:.:.:.|.    ||::..:
Human   498 MRERSELV----NVCVHSVFS----LPSVQAM--------------------------------- 521

  Fly   949 QQLKMKFDSQEEDERNSFLAKHL-NESLPQLNALVRAIVELDASPATLDLIIGILEGWTRDRNSE 1012
                     ||:||..:...:.| :::|..|..|::|:...|.:||.|..|:..|..|.....:.
Human   522 ---------QEKDEAKAETIQALYHQTLEALQTLLKALFIEDPTPAGLKSILEALGPWMNSGKAH 577

  Fly  1013 VRICASH----VFNNTLDVYIKSMKIGCEAPSKFNQTGQMLGKIVPRCIDSNGTVRQVSVEILQK 1073
            .|..|.:    |.|:.|......|.:|      |...|.:||:::....|.:   .::..|.|..
Human   578 ERARAVNTNVSVLNHMLLTLPFFMPLG------FPALGLLLGRLILHIGDPD---EEIGCEALDG 633

  Fly  1074 TLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQIYNLAGDIAKIIALRISSF-QYL-- 1135
            .:.:..|.| |...:.|......||:....:|.:..     ||.......|:.: |..| .:|
Human   634 IIILYTILE-LQKRARDKEETNKKELYESNKHFLGP-----YNPVSPCQNILRV-IEEFGDFLGP 691

  Fly  1136 -QFCKTLLHSL-----------RDPEQSSTIGASVVLKFFIQQKGSELFHAIPDLVRDSLLALRV 1188
             |....||.:|           :|..:...:.:.|:|...::.........||::::...:.|..
Human   692 QQIKDLLLAALEGLKGSSEAPGKDSREMMQLASEVMLSSVLEWYRHRALEVIPEIMQGIYMQLSH 756

  Fly  1189 CEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDPNLVEYWH--LVCNDPELTGLTLDNFLQ 1251
            .:.|||:...|..:..|.......|...:|..|||.:.|..|.|.  ::|.    ....:.:.|.
Human   757 IQEPRARQVALLPVSLLASSFMTEVVVALLMCPLPLNSNGAEMWRQLILCK----PSCDVRDLLD 817

  Fly  1252 LLSGASLQEGGQDASLSERQKLASGQ----PFAIFCALHEMLPCKDIKGQLETRFADMFCMLLTS 1312
            ||.|          ||.|:.....|:    |.|....|.|:|......|::...:..:...||..
Human   818 LLLG----------SLKEKPVTKEGRASIVPLAAASGLCELLSVNSCMGRVRRIYPQLLLALLIQ 872

  Fly  1313 LSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQI-----ALETFQAFLTNLE- 1371
            :..:..|..|..:    ..|..|:.|.....|||.:.::|:....:     :.||     |.||
Human   873 VHYHIGLNLPGCV----APPKDTKKGAQPSPFVPVRWVVKVVKTLLLRMGCSYET-----TFLED 928

  Fly  1372 ------MEQIASVLTVNTQLASSADWHNYIELLTPMAIGLGQQLQLGSPQMRQLVNSLSKYVASP 1430
                  |||:.|             .|..:.||....:      |....::.:::..|...:...
Human   929 QGGWELMEQVES-------------HHRGVALLARAMV------QYSCQELCRILYLLIPLLERG 974

  Fly  1431 YDGQRVAAVGIFSRLVPLKPTGELAASILL-HLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKR 1494
            .:..|:.|...|..|:.::....:.....| .:...||..:.:::.|||:|:..:.:..||.||
Human   975 DEKHRITATAFFVELLQMEQVRRIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILARRSEKTAK- 1038

  Fly  1495 YSETAIGALLKGVDDPVGDCLINIPLESMRGLSGILRALPSERVE-PFHVSLAIRIRPFLGNYAL 1558
             .:..:.:::||:.:..|..::    |::..|..:.:....:.:: ..:|.:...:.|...:...
Human  1039 -VKALLPSMVKGLKNMDGMLVV----EAVHNLKAVFKGRDQKLMDSAVYVEMLQILLPHFSDARE 1098

  Fly  1559 EMREAAIQLFGDICEGKHDDGSSSPTSSMEALREQLIANLFPLLLHLSESEVAIASACRGTLQRV 1623
            .:|.:.|.|:|.:.:...     :|.:  :|:.|||::.|.||||.:.|....::..|..||.|
Human  1099 VVRSSCINLYGKVVQKLR-----APRT--QAMEEQLVSTLVPLLLTMQEGNSKVSQKCVKTLLR- 1155

  Fly  1624 CRLLTA---PR--------------VVEMAEQQLGEERGHQLNYSSFVLEFVKTIALELTDHIQD 1671
            |....|   |:              |.::.:..:...|.....:.|..||:.|.....|......
Human  1156 CSYFMAWELPKRAYSRKPWDNQQQTVAKICKCLVNTHRDSAFIFLSQSLEYAKNSRASLRKCSVM 1220

  Fly  1672 FIDSCLPQLRSQWPEVR 1688
            ||.|.:|.:.|...|.|
Human  1221 FIGSLVPCMESIMTEDR 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
c11.1	NP_001285050.1	None
MROH7	NP_001034553.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..150
		HEAT 1	957..995	5/37 (14%)
		HEAT 2	1036..1074	7/43 (16%)
		HEAT 3	1079..1117	6/42 (14%)
		HEAT 4	1125..1162	14/37 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23120
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010