Protein Alignment c11.1 and MROH2A

DIOPT Version :9

• Sequence 1: NP_001285050.1
• Gene: c11.1 / 53436
• FlyBaseID: FBgn0040236
• Length: 1742
• Species: Drosophila melanogaster
• Sequence 2: XP_011509378.1
• Gene: MROH2A / 339766
• HGNCID: 27936
• Length: 1721
• Species: Homo sapiens
• Alignment Length: 1775
• Identity: 362/1775 - (20%)
• Similarity: 670/1775 - (37%)
• Gaps: 347/1775 - (19%)

  Fly    98 QQPKMTDQTVAMLLDCIRRVVGAETPLPPAANQKLIDLALQELTKNPEHLPLIQ-NPAQRILVAI 161
            |.|:::.|....:.:.::.::..|..|.....|:|:.:|.:|:.:.||....:: ..|...|||:
Human   119 QVPEISTQRKVNIYNILQDIIQQEGELEEQCVQRLVAIASKEMREIPEMEGYMKAEVASDTLVAL 183

  Fly   162 GRSSPESCEQVMEALQEKGTSTEGVAHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQ 226
            .|:   ....||..||...........|::: .|..||..|....:|::...|:.....|....:
Human   184 SRN---HFSLVMYELQHHLKPLNLTDEFVII-TLAKLANGNVFEFMPYMGITLATIFTMLRLANE 244

  Fly   227 DHIKQAHAYAIGRFSEAL------LEES--GKKEEENCSTEISVAYDVLFNQWLHSREPKVCVEI 283
            ..|:||...|:..|.|.:      ||||  ....||..:.::...|......||....|:|.:.:
Human   245 AKIRQAICSAMETFCETVQFYLKHLEESVYPVMTEEEFALKVFPMYRYFVTVWLRHYNPEVKLGV 309

  Fly   284 LQALSSMYP-LLPKDRIQDQAARLVPQILALYRRSVDRNAVTQFLCSVLKTNLALNATVLDGIID 347
            :::|..|.. |||.|.:::|....:|.:||.|:.|::...|||.|..:|:.::..|..|....:.
Human   310 IKSLKPMLGLLLPNDDLREQVYDYIPLLLAEYQGSLEVLFVTQVLRQILELSVTTNTPVPQMQLH 374

  Fly   348 VLVTHLFDLVCVYPDYEKPQTVKGHYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSL 412
            .:.|.|...||.....:...:.:...|::.||..||  :.|...:|......:..|.|..|:.:|
Human   375 TIFTELHVQVCNKAPAQHQYSSQNLMEMVHCFVALA--RSYPKELMKFFFSQMETNKEAVRVGTL 437

  Fly   413 LILTHLLNSCAGNIENR-IPATIECLKQLILSERGIKMKLTLLKTIVALAQKSHIRDKEFVWFVV 476
            .::..::::....:..| |...|..:|..|...|. |:::.:|..|..||
Human   438 NLIRAIVSADEPRMSIRAIYLAIRVVKNTISDTRS-KVRMAILHIIGQLA--------------- 486

  Fly   477 RHSCRFSKPSQEHGSQEEHANLVLS------------------------CENTLYMLASTVGTLD 517
              .|.:.:..:..|.:.....|.||                        ..:|:.::.|:|..:.
Human   487 --LCGYQERIKGWGLKYLSVQLTLSTYKLTNRREKFYQRDLEERMVHKVTMDTVKIITSSVSGMT 549

  Fly   518 ELLKRELLNYLILLDY----TDICGNLAKCLASLFAKSPHIEYDIAGDDAATEQATPESMGAAGE 578
            ......||.|::..||    |.||.:|.. ||         |:.:.|.|.        .:..||:
Human   550 TEFWVRLLCYIMETDYVEALTPICISLTN-LA---------EHQLHGQDV--------DVSVAGK 596

  Fly   579 DRSVIKRGKVMVPGAETIYARCLALL-----GNQQCIKRCSNILSFLRYYHPQVNPALEELWERK 638
            .|      :|.:|..:.:.||.|.|:     |..:.|.    :|:.||.....:.|::.::||.:
Human   597 SR------QVDLPAPQKLLARLLVLMSSPYKGEGRGIA----MLNLLRTLSQSIAPSMADMWELE 651

  Fly   639 IPDLLLQINR-------ESAYRQLLHDFVLETNEFLGGLDENFAQRLASKLADQMYLYPMQLPHS 696
            |..|:..:..       :.|:...|..|:..:.:...|  .:::.||:.:|.:|:         :
Human   652 IALLVRYLEEHTEFTWDQKAWEDKLIQFLRNSLKKTRG--SSWSLRLSKELNNQI---------A 705

  Fly   697 EWHLPDLSAERGMLLQAVALTL---LQVTDVACIHTKIDLIVTTARQERLDK------------- 745
            .:..|.|  |:|.|.:|:..||   |:.:.|..:  .::|:..|......|.
Human   706 SFDSPSL--EKGFLYRALGFTLATGLEASKVEVL--LLELLYKTDYSNDFDSEGVIMCFGLCARG 766

  Fly   746 ------HVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGRKHSTGFFSNLHFIKDTH 804
                  :|.| |:|:||:...::.                   |:...:            ||..
Human   767 QVKTVLNVLH-DFEERIQESEQSW-------------------QISAWR------------KDHP 799

  Fly   805 KELENYKSNLLVVKAFGRIMDEADPLQSIQHLDEDDTLLGFLIQQLAVHKDQTIMSA----ILQT 865
            ...|..||.|:|:  :..:.....| |.:.:| .|..:...:|... |...|...||    :..|
Human   800 WRRETVKSALMVM--YSCVASYCHP-QLLLNL-VDSPITAKIIHHY-VSSCQVAPSAAWGDVFWT 859

  Fly   866 LLSICNQLIATKEQLPAPLRHRKQIMETVFNIPIEAPFHDLPLLPTILKLGTDFIRIGGPDTEEC 930
            .|.||.::...|..:        |:.:.:.||.....|| .....|:..:....|:....|
Human   860 RLDICLKMAFMKSVV--------QVTKAINNIKDLEDFH-FAQKTTLTSIIVAVIKAEPTD---- 911

  Fly   931 VDGGVIFEIACRNFFGCAQQLKMK-FDSQEEDER------NSFLAKHL----NES--------LP 976
               .::..:........:...|:| |.|.||:..      :|.::..|    |||        |.
Human   912 ---NLVSPVRALAMEALSHLSKLKPFYSTEENSELMDISIHSVISLQLPGEDNESIKTLYANALS 973

  Fly   977 QLNALVRAIVELDASPATLDLIIGILEGWTRDRNSEVRICASHVFNNTLDVYIKSMKIGCEAPSK 1041
            .|..|:.::::....|..|..::.:||.|........|..|..:....:.:|:.|..:....  |
Human   974 SLEQLMESLLQRQLDPKGLQEMVQLLEKWILSEKEWEREKAVSLHLYLMWIYVHSTAVCIHL--K 1036

  Fly  1042 FNQTGQMLGKIVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTIASIDSTADW----LKEIETI 1102
            ..|.|.|:|.|.|...|::...|..|:.:|...|::.. .:|.::        |    .||:|..
Human  1037 LGQFGTMVGLIAPCTCDAHQRTRMASMNVLSSLLDLHA-SQTCSL--------WGPSKQKELEKC 1092

  Fly  1103 KEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTIG-----ASVV-LK 1161
            |..:.:.:.::|:..:..|||::.:..|..:.:...:.|.      |.:..:.     |||. :.
Human  1093 KGDLQSTDVEKIFCASSRIAKVVCMEFSCDEVVSLIQKLC------ENTGAMNLQHDKASVTWIA 1151

  Fly  1162 FFIQQKGSELFHAIPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDP 1226
            ||:|.:..||...:.:::...|:.|.|.:.|..:..::..::.|..||.:.:...:|.||||.:.
Human  1152 FFLQMRAKELEDKVAEILSAILVHLPVVDHPEVRRLLIDGILLLAHHHQETILTSLLRQPLPMES 1216

  Fly  1227 NLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQPFAIFCALHEMLPC 1291
            :|.|.|..|..:.......|.:.:..|. :.|.......|.::..:||:..|....|.:|.::..
Human  1217 HLAEVWLAVSENVPFARTMLHSLMGRLQ-SRLSPRISATSKADIWRLAAVDPLMTLCTIHLLIQK 1280

  Fly  1292 KDIKGQLETRFADMFCMLLTSL-SSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNP 1355
            .|...:|.....|:...||..| ||:...|||..:....|...           .|..|  ::|.
Human  1281 LDENDKLPDFLPDLIYTLLLQLGSSHRPEAAPPVLKMWKLVHT-----------TPLPE--EMNL 1332

  Fly  1356 CQIALETFQAFLTNLEMEQIASVLTVNTQLASSADWHNYIELLTPMAIGLGQQLQLGSPQMRQLV 1420
            .::.:::.|.....::.:.:|..|..........|...::|.::.:|....|.::....::.:||
Human  1333 QRVTIKSMQLLFKRVKSQHLAHTLDEQAVWDLLQDGGTFLEGVSLLARLCMQHVEGHRQRLAELV 1397

  Fly  1421 -NSLSKYVASPYDGQRVAAVGIFSRLV-----PLKPTGELAASILLHLGAALSDPNAVVRGLSIQ 1479
             ..:...|.|.........|...|..|     .|||     |::||..||...:..| :|.||::
Human  1398 LRGMDSEVLSCRISSTAVCVEFMSGPVLYQEKLLKP-----AALLLEKGADQEEDEA-LRVLSLR 1456

  Fly  1480 GMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGDCLINIPLESMRGLSGILRALPSERVEPFHVS 1544
            .:|.:.....|:.|:|.:..:...|..:.:||.:   ::..|.|..|:.||..|....|.....:
Human  1457 ALGNMALGAPKKVKQYRKVLLEKCLGPLREPVSN---SVTAEGMEALTKILAELREGDVGSSFDA 1518

  Fly  1545 LAIRIRPFLGNYALEMREAAIQLFGDICE--GKHDDGSSSPTSSMEALREQLIANLFPLLLHLSE 1607
            ::.:.|.|..|.:..:|..|..|||.:..  |         .|.....:.::.....||:||..:
Human  1519 MSEQCRIFFDNESELLRLKAFILFGKLARVVG---------MSKKHFFKGEVKKAWIPLMLHSQD 1574

  Fly  1608 SEVAIASACRGTL-------------------------------QRVCRLLTAPR---------- 1631
            .....|.||..|:                               ..:|.:||..:
Human  1575 PCSNAAQACMATMFQCVHFWGWKSLEHPSGPSDTATDDKMTVFQTTMCSILTRKKPAVLYRFLLE 1639

  Fly  1632 VVEMAEQQLGEERGHQLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQW--------PEVR 1688
            .:...:..|...|....|.:..:::.:.|..|:..|         .|.||:..        |.||
Human  1640 TMAYVKNNLSRIRIAACNLAGIIMKQMSTHYLKKLD---------FPALRNSLQELQLDPDPGVR 1695

  Fly  1689 GSAAIVIGIL-----HNFLS 1703
            .:|...:.:|     |.||:
Human  1696 RAALETLTVLDSCSQHGFLA 1715

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I795
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1917
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41881
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.930