Protein Alignment c11.1 and Mroh2b

DIOPT Version :9

• Sequence 1: NP_001285050.1
• Gene: c11.1 / 53436
• FlyBaseID: FBgn0040236
• Length: 1742
• Species: Drosophila melanogaster
• Sequence 2: NP_001159538.1
• Gene: Mroh2b / 223825
• MGIID: 1921905
• Length: 1581
• Species: Mus musculus
• Alignment Length: 1729
• Identity: 339/1729 - (19%)
• Similarity: 663/1729 - (38%)
• Gaps: 354/1729 - (20%)

  Fly   130 QKLI-----DLALQELTKNPEHLPLIQNPAQRILVAIGRSSPESCEQVMEALQEKGTSTEGVAHF 189
            |:||     |:..:|:   |..|.::   |..:||::   :......||..:|......|....|
Mouse    49 QRLIYYTSKDMRDEEI---PRELRML---AGEVLVSL---AAHDFNSVMYEVQSNFRILELPNEF 104

  Fly   190 MLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGRFSEALLEESG----- 249
            ::: .|..|||...:..:|.:...|...|..|..:..::::|....|:..||:::.:...
Mouse   105 VVL-ALAELATSYVSQSIPFMMMTLLTMQTMLRLVEDENMRQTFCIALENFSKSIYKYVNHWKDF 168

  Fly   250 ---KKEEENCSTEISVAYDVLFNQWLHSREPKVCVEILQALS-SMYPLLPKDRIQDQAARLVPQI 310
               |.:....|.:|.:.:..:..:|.....|...:.|::|.. ::..||.::...:.|...:..:
Mouse   169 PYPKLDANRLSDKIFMLFRYIMEKWAPQASPMHALAIIKAHGPTVSLLLHREDFCEFALSQISWL 233

  Fly   311 LALYRRSVDRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLVCVYPDYEKPQTVKGHYEV 375
            |..||...:...:||.|..:|...:..:..:...:...:::.|...:|..|:   |...:...|.
Mouse   234 LLQYRDKENDFYITQSLKQILTAAVLYDIALPKNLRRSVLSSLLHQICKVPE---PPIKENKLEA 295

  Fly   376 LRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIECLKQL 440
            ..||.:||...|..  ::|.....:|:.:|..|...|.:|...:|:......|. ..:||...:|
Mouse   296 SSCFLILAHANPVD--LLDFFDEQIRSTNEAVRTGILTLLRSTINAEEPKFRNH-TTSIEKTVKL 357

  Fly   441 ILSERGIKMKLTLLKTIVALAQKSHIRDKE--------FVWFVVRHSCRFSKPSQEHGSQEEHAN 497
            ::.:..:|::.:.|..|..:.:|.:|..:|        |..|.:.:. ....|.:.:..::|:..
Mouse   358 VMGDLSVKVRKSTLLLIQTMCEKGYIEAREGWPLIDYIFSQFAMSNR-NLENPIKSNSQEDENGE 421

  Fly   498 LVLSCENTLYMLAS----TVGTLDELLKRELLNYLILLDYTDICGNLAKCLASLFAKSPHIEYDI 558
            ..:. |.:|.:|.|    .:| :.::|...:|.|::..:||.....|...:..|.......:.||
Mouse   422 KSVQ-ETSLEVLKSLDPLVIG-MPQVLWPRILTYVVPKEYTGTLDYLFNIIRILIMAEEKKKRDI 484

  Fly   559 AGDDAATEQATPESMGAAGEDRSVIKRGKVMVPGAETIYAR-----CLALLGNQQCIKRCSNILS 618
            ....|.                 |:..|.|.:|..:.:.||     .||.|| |.|......:|.
Mouse   485 QESTAL-----------------VVSTGAVKLPSPQQLLARLLVISILASLG-QLCGAGAIGLLK 531

  Fly   619 FLRYYHPQ-VNPALEELWERKIPDL-----------------LLQINRESAYR--------QLLH 657
            .:    |: ::|.|.|:|:.::|.|                 |||:.:||.::        ||..
Mouse   532 IM----PEIIHPKLAEMWKTRMPALLQPLEGSNASIVLWETMLLQLLKESLWKISDVAWTSQLSR 592

  Fly   658 DFVLETNEFLGGLDENFAQRLASKLADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQVT 722
            ||.|:...:                                  .:.|.|:..|.:|:..||....
Mouse   593 DFSLQMGSY----------------------------------SNSSMEKKFLWKALGTTLASCQ 623

  Fly   723 DVACIHTKIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGR 787
            |...:.::|:..:.|  ...|..|         .:.....||:.:..||..::..|...
Mouse   624 DKDFVSSQINEFLVT--PSLLGDH---------RQGTTSILGFCAENHLDIVLNVLKTF------ 671

  Fly   788 KHSTGFFSN-LHFIKDTHKELENYKSNLLVVKAFGRIMDEADPLQSIQHLDEDD-----TLLGFL 846
            :....||.| ...|....|.|.  |::|:::  :|.:...|...|.:..||:|.     .|.|..
Mouse   672 QDKEKFFVNRCKGIFSGKKSLT--KTDLILI--YGAVALHAPKQQLLARLDQDIMGQILLLYGQC 732

  Fly   847 IQQLAV---HKDQTIMSAILQTLLSICNQLIATKEQLPAPLRHRKQIMETVFNIPIEAPFHDL-- 906
            .|.|.|   :||..:..:..:::..: ...:...|.......:::.::.::.::..:.|.:.|
Mouse   733 CQILGVSVINKDMDLQMSFTRSITEV-GIAVQDAEDQKFQFTYKEMLIGSMLDLIKDEPLNTLAS 796

  Fly   907 PL-------------LPTILKLGTDFIRIGGPDTEECVDGGVIFEIACRNFFGC--AQQLKMKFD 956
            |:             |...|.| .|.:.|    .||.:          |.....  .::||.:.:
Mouse   797 PVRWKVLIAIRYLSKLKPALSL-NDHLNI----LEENI----------RRLLPLPPLEKLKSQGE 846

  Fly   957 SQEEDERNSFLAKHLNESLPQLNALVRAIVELDASPATLDLIIGILEGWTRDRNSEVRICASHVF 1021
            :.::.||..||   ...|:..|..|:|:::..:......:.:..:|..|...:....|   ...|
Mouse   847 TDKDRERIEFL---YERSMDALGKLLRSMIWDNTDAQNCEEMFNLLRMWLVSQKQWER---ERAF 905

  Fly  1022 NNTLDVYIKSMKIGCEAPSKFNQTGQMLGKIVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTI 1086
            ..|..|..|.:    |||..| :.|.:||.:.|...|:..|:||.:.   ..|:.:.|      .
Mouse   906 QVTSKVLTKDV----EAPQNF-RIGSLLGLLAPHSCDTLPTIRQAAT---SSTIGLLC------A 956

  Fly  1087 ASIDSTADWLKEIETIKEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQS 1151
            ..|....|   .::.::|.:.:::.:....::..||||:...|.|.:...|.:..|..|...:..
Mouse   957 KGICQEVD---RLQGLQEGLDSEDEQVQIKISSKIAKIVCKFIPSEEIQVFLEETLDGLETLDPL 1018

  Fly  1152 STIGASVVLKFFIQQKG-----------SELFHAIPDLVRDSLLALRVCEVPRAKSGVLKALVAL 1205
            .|....:.:...:::.|           |.::|.:|        .||..|  .:...:|:|:..:
Mouse  1019 CTKACGIWMIAALKEHGALLEDQLLEILSTIYHHMP--------VLRQKE--ESFQFMLEAISQI 1073

  Fly  1206 TKHHPKLVCAEMLSQPLPYDPNLVEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSER 1270
            ...|...|...:|.:|||:|.:....|..:..:|..:|..:...::.|. |.|::
Mouse  1074 ASFHMDAVVNNLLQKPLPFDRDTKTLWKALAENPASSGKLMRALIKKLV-ARLED---------- 1127

  Fly  1271 QKLASGQPFAIFCALHEMLPCKDIKGQLETR-FADMFCMLLTSLSSYTNLAAPNPINNASLSPNQ 1334
             .:|..:..::.||::|::    :.|...|. :.::|.:||..:|  .:|....|::..|.....
Mouse  1128 -DIAGTEAISVACAIYEVI----LTGAHITHLYPELFTLLLKLVS--CSLGQKMPMSTLSQRRRV 1185

  Fly  1335 TQSG-KTKFGFVPNKELIKLNPCQIALETFQAFLTNLEMEQIASVLTVNTQ---LASSADWHN-- 1393
            .|.| :.:|.          :||:::..|.:........|.:|........   |.|:.|.|:
Mouse  1186 MQLGERQRFP----------DPCRLSTATLKCLQAQAMREGLAKESDEGDNLWTLLSNPDTHHIG 1240

  Fly  1394 YIELLTPMAIGL-GQQLQLGSPQMRQLVNSLSKYVASPYDGQRVAAVGIFSRLVP---LKPTGEL 1454
            ...|...||:.. |..|.:    |..|::||:    |..:..|:..:..||.|:.   |...|.|
Mouse  1241 VCALARSMAVWQHGVILDI----MEHLLSSLT----SSSENYRITGMAFFSELMKEPILWKHGNL 1297

  Fly  1455 AASILLHLGAALSDPNAVVRGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGDCLINIP 1519
             ..:|:.:.....|.||::|.::|:|:|........:.::|.:..:..:::|:   .......:.
Mouse  1298 -RDVLIFMDQNARDSNAILRQMAIRGLGNTACGAPHKVRKYKQMMLECIIRGL---YHLARTEVV 1358

  Fly  1520 LESMRGLSGILRALPSERVEPFHVSLAIRIRPFLGNYALEMREAAIQLFGDICEGKHDDGSSSPT 1584
            .||::.|..||..|....:..:...:.::.|.|..:...::|..||.||.|:
Mouse  1359 CESLKALKKILELLTERDINFYFKEIVLQTRTFFEDEQDDVRLTAISLFEDL------------- 1410

  Fly  1585 SSMEALR------EQLIANLFPLLLHLSESEVAIASACRGT---------LQRVCRLLTAPRVVE 1634
            :::...|      |::..::...||||.:....|.:|||..         ||.:..||.     .
Mouse  1411 ATLTGRRWKIFFAEEVKKSMISFLLHLWDPNPKIGAACRDVLVICIPFLGLQELYGLLD-----H 1470

  Fly  1635 MAEQQLGEERGHQLNYSSFVLEFVKTIALELTDHIQDFI----DSCLPQLRSQWPEVRGSAAIVI 1695
            :.|:.|...|           :|.:.:.::|:...|:.:    ........|.|..:| |||:.:
Mouse  1471 LLERDLPRAR-----------DFYRQLCMKLSKKNQEILWILHTHSFTFFTSSWEMIR-SAAVKL 1523

  Fly  1696 G---ILHNFLSERNVQTETVASKIAVLLKDEQALVRMRA 1731
            .   |||  |::|.|:          ||..||..:|::|
Mouse  1524 TDAIILH--LTKRYVE----------LLDREQLTMRLQA 1550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_001285050.1	None
Mroh2b	NP_001159538.1	HEAT 1	123..160		7/36 (19%)
		HEAT 2	305..342		8/38 (21%)
		HEAT 3	401..441		6/41 (15%)
		HEAT 4	464..501		8/53 (15%)
		HEAT 5	526..543		4/20 (20%)
		HEAT 6	544..580		8/35 (23%)
		HEAT 7	658..695		9/44 (20%)
		HEAT 8	773..815		4/41 (10%)
		HEAT 9	960..997		6/39 (15%)
		HEAT 10	1017..1055		5/45 (11%)
		HEAT 11	1112..1150		8/53 (15%)
		HEAT 12	1153..1191		9/39 (23%)
		HEAT 13	1254..1291		11/44 (25%)
		HEAT 14	1295..1332		10/37 (27%)
		HEAT 15	1359..1379		6/19 (32%)
		HEAT 16	1380..1416		8/48 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I935
eggNOG	1	0.900	-	-		E1_KOG2032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2074
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54925
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43929
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.940