DRSC/TRiP Functional Genomics Resources

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Protein Alignment c11.1 and MROH2B

DIOPT Version :9

Sequence 1:NP_001285050.1 Gene:c11.1 / 53436 FlyBaseID:FBgn0040236 Length:1742 Species:Drosophila melanogaster
Sequence 2:NP_775760.3 Gene:MROH2B / 133558 HGNCID:26857 Length:1585 Species:Homo sapiens


Alignment Length:1844 Identity:349/1844 - (18%)
Similarity:682/1844 - (36%) Gaps:453/1844 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 NIFDGLMDKEEQVRIAMQQAIVKILETHPERAAEILSEHRSQQPKMTDQTVAMLLDCIRRVVGAE 121
            |:..|:::||:.|.                  .|.:..|.:...:.||     :||         
Human    16 NLTLGMLNKEDIVN------------------KEDIYSHLTSVIQNTD-----ILD--------- 48

  Fly   122 TPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRILVAIGRSSPESCEQVMEALQEKGTSTEGV 186
                .|..|:||..|.:::..| ..|..|:..|..:||::   :......||..:|......|..
Human    49 ----DAIVQRLIYYASKDMRDN-NMLREIRMLAGEVLVSL---AAHDFNSVMYEVQSNFRILELP 105

  Fly   187 AHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGRFSEALLEESG-- 249
            ..|::: .|..|||...:..:|.:...|...|..|.....:.:|.....|:.:||:|:.:...  
Human   106 DEFVVL-ALAELATSYVSQSIPFMMMTLLTMQTMLRLAEDERMKGTFCIALEKFSKAIYKYVNHW 169

  Fly   250 ------KKEEENCSTEISVAYDVLFNQWLHSREPKVCVEILQALS-SMYPLLPKDRIQDQAARLV 307
                  :.:....|.:|.:.:..:..:|.....|...:.|::|.. ::..||.::..:..|...|
Human   170 RDFPYPRLDANRLSDKIFMLFWYIMEKWAPLASPMQTLSIVKAHGPTVSLLLHREDFRGYALGQV 234

  Fly   308 PQILALYR-RSVDRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLVCVYPDYEKPQTVKG 371
            |.:|..|: :.:|.: |||.|..:|...:..:..:...:...:..:|...:|..|:   |...:.
Human   235 PWLLNQYKDKEIDFH-VTQSLKQILTAAVLYDIGLPRSLRRSIFINLLQQICRAPE---PPVKEN 295

  Fly   372 HYEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIEC 436
            ..:...||.:||...|  ..:|:.....:|:|:|..|:..|.:|...:|:....:.:.| .:||.
Human   296 EMKASSCFLILAHSNP--GELMEFFDEQVRSNNEAIRVGILTLLRLAVNADEPRLRDHI-ISIER 357

  Fly   437 LKQLILSERGIKMKLTLLKTIVALAQKSHIRDKEFVWFVVRH--------SCRFSKP--SQEHGS 491
            ..::::.:...|::.::|..|..:.:||:|..:| .|.::.:        :....||  :..|.:
Human   358 TVKIVMGDLSTKVRNSVLLLIQTMCEKSYIEARE-GWPLIDYVFSQFATLNRNLEKPVKTNFHEN 421

  Fly   492 QEEHANLVLSCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKCLASLFAKSPHIEY 556
            ::|..::..:....|..|...|..:.::|...:|.:::..:||:....|...:..|.        
Human   422 EKEEESVRETSLEVLKTLDPLVIGMPQVLWPRILTFVVPAEYTEALEPLFSIIRILI-------- 478

  Fly   557 DIAGDDAATEQATPESMGAAGEDRS-VIKRGKVMVPGAETIYARCL-----ALLGNQQCIKRCSN 615
                      .|..:...:|.|..: |:..|.|.:|..:.:.||.|     |.||.    .|.:.
Human   479 ----------MAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGE----LRGAG 529

  Fly   616 ILSFLRYYHPQVNPALEELWERKIPDL-----------------LLQINRESAYR--------QL 655
            .:..|:.....::|.|.:||:.::|:|                 |||:.:||.::        ||
Human   530 AIGLLKILPEIIHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQL 594

  Fly   656 LHDFVLETNEFLGGLDENFAQRLASKLADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQ 720
            ..||    .:.:|....|                              |.|:..|.:|:..||..
Human   595 TQDF----KQQMGSYSNN------------------------------STEKKFLWKALGTTLAC 625

  Fly   721 VTDVACIHTKIDLIVTTARQERLDKHVKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVG 785
            ..|...::::|...:|...|        ..|..:.|   ...|||.:..||..::|.|...    
Human   626 CQDSDFVNSQIKEFLTAPNQ--------LGDQRQGI---TSILGYCAENHLDIVLKVLKTF---- 675

  Fly   786 GRKHSTGFFSNLHFIKDTHKELENYKSNLL---VVKAFGRIMDEADPLQSIQHLDEDDTLLGFLI 847
              ::...||.|      ..|.|.:.|.:|.   |:..:|.:...|...|.:..|::|     .:.
Human   676 --QNQEKFFMN------RCKSLFSGKKSLTKTDVMVIYGAVALHAPKKQLLSRLNQD-----IIS 727

  Fly   848 QQLAVH-------------KDQTIMSAILQTLLSICNQLIATKEQ-------------------- 879
            |.|::|             ||..:..:..:::..|...:...::|                    
Human   728 QVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRD 792

  Fly   880 -----LPAPLRHRKQI-------------METVFNIPIEAPFHDLPLLPTILKLGTDFIRIGGPD 926
                 |.:|:|.:..|             ::...||..|.....|||.|                
Human   793 EPLDSLASPIRWKALIAIRYLSKLKPQLSLQDHLNILEENIRRLLPLPP---------------- 841

  Fly   927 TEECVDGGVIFEIACRNFFGCAQQLKMKFDSQEEDERNSFLAKHLNESLPQLNALVRAIVELDAS 991
                                 .:.||.:..:.::.|...||   ...|:..|..|::.::..:.:
Human   842 ---------------------LENLKSEGQTDKDKEHIQFL---YERSMDALGKLLKTMMWDNVN 882

  Fly   992 PATLDLIIGILE-------GWTRDRNSEVRICASHVFNNTLDVYIKSMKIGCEAPSKFNQTGQML 1049
            ......:..:|:       .|.|:|..::   .:.|..|.:           |||..| :.|.:|
Human   883 AEDCQEMFNLLQMWLVSQKEWERERAFQI---TAKVLTNDI-----------EAPENF-KIGSLL 932

  Fly  1050 GKIVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTIASIDSTADWLKEIETIKEHIITDEPKQI 1114
            |.:.|...|:..|:||            |....|:.:..|......::.::.::|.:.:|:.:..
Human   933 GLLAPHSCDTLPTIRQ------------AAASSTIGLFYIKGIHLEVERLQGLQEGLESDDVQVQ 985

  Fly  1115 YNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTIGASVVLKFFIQQKGSEL-------- 1171
            ..::..||||::..|.:.:.|.|.:.:|..|.....:.|....:.:...::|:|:.|        
Human   986 IKISSKIAKIVSKFIPNEEILMFLEEMLDGLESLNPTCTKACGIWMITVLKQQGAALEDQLLEIL 1050

  Fly  1172 ---FHAIPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDPNLVEYWH 1233
               :|.:|        .||..|  .:...:|:|:..:...|...|...:|.:|||:|.:....|.
Human  1051 GTIYHHMP--------VLRQKE--ESFQFILEAISQIASFHMDTVVVNLLQKPLPFDRDTKTLWK 1105

  Fly  1234 LVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQKLASGQPFAIFCALHEMLPCKDIKGQL 1298
            .:...|..:|..|...:..|          :..|.:  .:|..:..::.||::|::   .:...:
Human  1106 ALAEKPASSGKLLQALIDKL----------ETELED--DIARVEAISVACAMYEVI---SMGTSV 1155

  Fly  1299 ETRFADMFCMLLTSLS---SYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKELIKLNPCQIAL 1360
            ...:.::|.:||..:|   ....|..|.......:...:.|.       :|       :||:::.
Human  1156 TGLYPELFTLLLKLVSCTLGQKMLTCPWSHRRHVMQQGEQQQ-------IP-------DPCRLST 1206

  Fly  1361 ETFQAFLTNLEMEQIASVL----TVNTQLASSADWH-NYIELLTPMAIGL-GQQLQLGSPQMRQL 1419
            .|.:........|.:|...    .:.|.|:|.:..| ....|...||:.. |..|.:    |.||
Human  1207 ATLKCLQAQAMREGLAKESDEGDNLWTLLSSPSTHHIGVCSLARSMAVWQHGVILDI----MEQL 1267

  Fly  1420 VNSLSKYVASPYDGQRVAAVGIFSRLVP---LKPTGELAASILLHLGAALSDPNAVVRGLSIQGM 1481
            ::||:    |..:..|:.....||.|:.   |...|.| .::|:.:..:..|.||.:|.::|:|:
Human  1268 LSSLT----SSSENYRITGAAFFSELMKEPILWKHGNL-RNVLILMDQSAWDSNATLRQMAIRGL 1327

  Fly  1482 GYVGQLGEKEAKRYSETAIGALLKGVDDPVGDCLINIPLESMRGLSGILRALPSERVEPFHVSLA 1546
            |........:.|::.:..:.::::|:   .......:..||::.|..||..|....|..:...:.
Human  1328 GNTASGAPHKVKKHKQLMLESIIRGL---YHLARTEVVCESLKALKKILELLTDRDVSFYFKEIV 1389

  Fly  1547 IRIRPFLGNYALEMREAAIQLFGDICEGKHDDGSSSPTSSME---ALREQLIANLFPLLLHLSES 1608
            ::.|.|..:...::|..||.||.|:          :|.:...   ...|::..:|...||||.:.
Human  1390 LQTRTFFEDEQDDVRLTAIFLFEDL----------APLTGRRWKIFFAEEIKKSLISFLLHLWDP 1444

  Fly  1609 EVAIASACRGTLQRVC--------------RLL--TAPRV--------VEMAEQQ---LGEERGH 1646
            ...|..|||..|. ||              |||  ..||.        |::|::.   |.....|
Human  1445 NPKIGVACRDVLM-VCIPFLGLQELYGVLDRLLDQDLPRARDFYRQFCVKLAKKNQEILWILHTH 1508

  Fly  1647 QLNYSSFVLEFVKTIALELTDHIQDFIDSCLPQLRSQWPEVRGSAAIVIGILHNFLSERNVQTET 1711
            ...:.:...|.:::.|::|||.:       :..|.||:.|:                   :..|.
Human  1509 SFTFFTSTWEVIRSAAVKLTDAV-------VLNLTSQYVEL-------------------LDREQ 1547

  Fly  1712 VASKIAVLLKDEQALVRMRAATAL 1735
            :.:::..|.:|....|:..|..||
Human  1548 LTTRLQALRQDPCISVQRAAEAAL 1571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c11.1NP_001285050.1 None
MROH2BNP_775760.3 HEAT 1 28..65 12/72 (17%)
HEAT 2 228..263 11/35 (31%)
HEAT 3 272..309 8/39 (21%)
HEAT 4 310..346 9/37 (24%)
HEAT 5 405..445 7/39 (18%)
HEAT 6 531..569 7/37 (19%)
HEAT 7 572..611 12/72 (17%)
HEAT 8 662..699 11/48 (23%)
HEAT 9 777..819 4/41 (10%)
HEAT 10 964..1001 6/36 (17%)
HEAT 11 1021..1059 6/45 (13%)
HEAT 12 1112..1151 8/53 (15%)
HEAT 13 1157..1195 6/37 (16%)
HEAT 14 1258..1295 12/44 (27%)
HEAT repeat 1306..1329 CDD:293787 6/22 (27%)
HEAT repeat 1341..1374 CDD:293787 5/35 (14%)
HEAT 15 1363..1402 9/38 (24%)
HEAT repeat 1387..1424 CDD:293787 9/46 (20%)
HEAT repeat 1433..1458 CDD:293787 10/25 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 388 1.000 Domainoid score I795
eggNOG 1 0.900 - - E1_KOG2032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 403 1.000 Inparanoid score I1917
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54925
OrthoDB 1 1.010 - - D19783at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41881
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.840

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