DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c11.1 and mroh1

DIOPT Version :9

Sequence 1:	NP_001285050.1	Gene:	c11.1 / 53436	FlyBaseID:	FBgn0040236	Length:	1742	Species:	Drosophila melanogaster
Sequence 2:	XP_031760422.1	Gene:	mroh1 / 100489995	XenbaseID:	XB-GENE-6038828	Length:	1657	Species:	Xenopus tropicalis

Alignment Length:	1764	Identity:	413/1764 - (23%)
Similarity:	771/1764 - (43%)	Gaps:	222/1764 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IFDGLMDKEEQVRIAMQQAIVKILETHPERAAEILSEHRSQQPKMTDQTVAMLLDCIRRVV-GAE 121
            :.|...||:.:|:..:..::..:.|..|....|....:..|..|::.....::|..:..:| .:.
Frog    13 LMDASTDKDPEVQEQIYSSLCFMGEAAPTEILESCDSYLRQHDKLSYAHRTIILRAMETIVKNSL 77

  Fly   122 TPLPPAANQKLIDLALQELTKNPEHLPLIQNPAQRILVAIGRSSPESCEQVMEALQEKGTSTEGV 186
            ..|.....:.:|.||..|:||:.:.:...|..|..:||||||   .....|||.:..|  ...|:
Frog    78 KALTKETAKMVILLASNEMTKSKDIIFEWQQGASNVLVAIGR---HFINNVMEEILVK--FQPGI 137

  Fly   187 -AHFMLMQCLGLLATENPAGVVPHIKAILSRSQPHLVGIRQDHIKQAHAYAIGRFSEALLEESGK 250
             .||.:||.|..|:..|..|:||.:.:||....|.|...:||.:|.....|:..|||::.|....
Frog   138 LPHFFIMQTLANLSVANVFGMVPFLNSILGTMLPMLGMAKQDPMKAVFCVALQHFSESIQEYLAN 202

  Fly   251 KE--------EENCSTEISVAYDVLFNQWLHSREPKVCVEILQALSSMYPLLPKDRIQDQAARLV 307
            .:        ::..|.||..|||||||.||.:||.||.:.:::||..|..|||.:::::|..|||
Frog   203 LDKAPDPTVRKDTFSNEIFNAYDVLFNTWLQNRESKVRLAVVEALGPMSHLLPNEKLEEQLPRLV 267

  Fly   308 PQILALYRRSVDRNAVTQFLCSVLKTNLALNATVLDGIIDVLVTHLFDLVCVYPDYEKPQTVKGH 372
            |.||:||:::|:...||:..|.:|::.::..:..|:|::|.::..|...:|:..|......|:..
Frog   268 PGILSLYKKNVEALFVTKSFCQILESAVSNESRTLEGLMDSILGALHSQICLSLDSSNQMLVRNQ 332

  Fly   373 YEVLRCFHLLAGHQPYSTRIMDTLLIHLRNNSERERMKSLLILTHLLNSCAGNIENRIPATIECL 437
            .||||||.:|....|  ..::..||..|..||.:.|:.:|:|:..::||...::|.:.|..:..:
Frog   333 NEVLRCFTVLVSRFP--DHLLAFLLPKLEANSPKVRVGTLVIMKQVINSAPTSMEVKKPLILAAV 395

  Fly   438 KQLILSERGIKMKLTLLKTIVALAQKSHIRD---KEFVWFVVRHSCRFSKPS--QEHGSQEE--H 495
            :| .|.:...:::..:::.|.|:|...::..   :..:.:::|..|....||  |::...||  .
Frog   396 RQ-PLQDPTNRVRRAMVQLISAMAHHGYLEQPGGELLLEYLIRLCCVTPSPSSRQQNSEPEEVTE 459

  Fly   496 ANLVLSCENTLYMLASTVGTLDELLKRELLNYLILLDYTDICGNLAKCLASLFAK--SPHIEYDI 558
            .|:.....:|||::::||..::.:|...||.:::.:.:::....:.|.|..|..|  :..:|..:
Frog   460 ENVRRISISTLYLISTTVDRMNNILWPYLLEFIVPVQFSNALTPICKSLVQLGQKRQAESVETFL 524

  Fly   559 AGDDAATEQATPESMGAAGEDRSVIKRGKVMVPGAETIYARCLALLGNQQCIKRCSNILSFLRYY 623
            ...:..|...:|.::.|     .::.....:.||.           |......|..|::..
Frog   525 INYNVHTNLPSPHALVA-----RLLVAAAALEPGD-----------GRSSAALRLLNVMQI---- 569

  Fly   624 HPQVNPALEELWERKIPDLLLQINRESAYRQLLHDFVLETN--EFLG-----GLDENFAQRLASK 681
              .::|.:...|:::|| |||....|.....||.....|..  :|||     ..|:.:..:|..:
Frog   570 --NIHPTVGRCWDQEIP-LLLNCLEEHGAESLLQQNEWEDKMLKFLGVTLQAVADDKWISQLGQE 631

  Fly   682 LADQMYLYPMQLPHSEWHLPDLSAERGMLLQAVALTLLQVTDVACIHTKIDLIVTTARQERLDKH 746
            :..|:..|           ..|..|:..|.:.:..||........:..::.::::|||.:.
Frog   632 MHQQLLSY-----------NSLPLEKNFLYKCIGTTLAACEKREVVRKQLQVLLSTARYQE---- 681

  Fly   747 VKHADYEKRIEPCARALGYISRQHLGHLIKKLTELAQVGGRKHSTGFFSNLHFIKD-THKELENY 810
                  |...|..|.|.|..|.:||...:..|.:..:....|.:.|.|   :..|| ...:||..
Frog   682 ------ESEREGLAVAFGICSARHLDEALDTLGDFLKSDIMKRNAGIF---NLFKDRADGDLEKI 737

  Fly   811 KSNLLVVKAFGRIMDEADPLQSIQHLDEDDTL-----------LGFLIQQLAVHKDQTIMSAILQ 864
            ||:|::  .:|.:...| |::.:....|.:.|           ||..::.    ||.|:...:::
Frog   738 KSSLIL--CYGYVTVYA-PIELVLPRIECEILRNVFSYFHTKVLGIKVEP----KDLTLKLCLIR 795

  Fly   865 TL----LSICNQLIATKEQLPAPLRHRKQIMETVFNIPIEAPFHDLPLLPTILKLGTDFIRIGGP 925
            |:    |:||:.                          .:|.|........:|....:||:...|
Frog   796 TISMIGLAICSS--------------------------TQAGFFHFSRKAELLSHLLEFIKSEPP 834

  Fly   926 DTEECVDGGVIFEIACRNFFGCAQQLKMK---FDSQEEDERNSFLAK---------------HL- 971
            |   |:...    :..|....|...:|::   .|:.:.:...:.|:.               |:
Frog   835 D---CLKSA----LRQRALTACTYLVKLEPPLSDANKSELLTTCLSSVFSLSPVGSGAPGELHIQ 892

  Fly   972 ---NESLPQLNALVRAIVELDASPATLDLIIGILEGWTRDRNSEVRICASHVFNNTLDVYIKSMK 1033
               .:::..|..|:|:::..:.:|..|..:..:|..|.:......|..|..|....|:.|:..:.
Frog   893 TLYQDTVEALKDLLRSLLLWNLTPHGLQEMFQVLGPWIKSNKEHERDRAMEVSAALLECYLHKLN 957

  Fly  1034 IGCEAPSKFNQTGQMLGKIVPRCIDSNGTVRQVSVEILQKTLEIACIYETLTIASIDSTADWLKE 1098
            :....|  |...|.::|||.|||.||..:||:.:|:.:...|.|...||..   :.|...:.:::
Frog   958 VNAMVP--FYNLGLLIGKISPRCSDSVASVRRRTVDCIYYLLYIQLRYEGF---APDHKDELVEK 1017

  Fly  1099 IETIKEHIITDEPKQIYNLAGDIAKIIALRISSFQYLQFCKTLLHSLRDPEQSSTIGASVVLKFF 1163
            :.:.|:.:...:|..:|:...::|.||..|:...|.:.........|.||:.:.:..|||::...
Frog  1018 LLSFKQGLQKPDPSVLYHTCFNVAMIIGKRLPPEQLISLLFITFEGLSDPDINCSRAASVMVNSL 1082

  Fly  1164 IQQKGSELFHAIPDLVRDSLLALRVCEVPRAKSGVLKALVALTKHHPKLVCAEMLSQPLPYDPNL 1228
            ::.:||.|...:||::......|:..:....:...|:.:..|...|.:.|.:.:||.||||....
Frog  1083 LKDRGSILLAKVPDIMARVEEQLQETQEAHVRKAALQTVYILASQHLEAVLSSLLSCPLPYASET 1147

  Fly  1229 VEYWHLVCNDPELTGLTLDNFLQLLSGASLQEGGQDASLSERQ---------KLASGQPFAIFCA 1284
            ...|..:.:||.||    ...|:||.|    :.|.|....|.:         ::|:..|.|..||
Frog  1148 CVLWGALSSDPPLT----SQVLELLMG----KMGVDVPYKESKSSLLSSVSGRVATLLPLAASCA 1204

  Fly  1285 LHEMLPCKDIKGQLETRFADMFCMLLTSLSSYTNLAAPNPINNASLSPNQTQSGKTKFGFVPNKE 1349
            :.|:|...|....::..:..:|..||..:|....:..|.     :|.|::.:...:.   .|:::
Frog  1205 VCEILSAPDSAPAVQELYPQLFVTLLLRISVMIGVQLPK-----NLGPSKDRKNSSS---PPSRD 1261

  Fly  1350 LIKLNPCQIALETFQAFLTNLEMEQIASVLTVNTQLASSADWHNYIELLTPMAIGL----GQQLQ 1410
               |:||..|:|..:..|:....|:      |...|.:...|.|..:..| ..:|:    ...:|
Frog  1262 ---LDPCGSAVEALKFMLSRGGSEE------VTCSLEAEGGWENMRKEET-HHLGVSSLSSSMVQ 1316

  Fly  1411 LGSPQMRQLVNSLSKYVASPYDGQRVAAVGIFSRLVPLKPTGELAA--SILLHLGAALSDPNAVV 1473
            ...|::..::.:|...::|.|:.||:.|....:.|:.....|.|..  .::.::.:.|.|....|
Frog  1317 YAGPKLPVILKALQPALSSVYERQRITATAFLAELLRSSNLGNLIVIEPLMDNMTSRLKDGAVTV 1381

  Fly  1474 RGLSIQGMGYVGQLGEKEAKRYSETAIGALLKGVDDPVGDCLINIPLESMRGLSGILRALPSERV 1538
            |.|:::|:|.:......:.:::....:.|::..:||......| :..|:|..|..:|..:..:.:
Frog  1382 RMLAVRGLGNMAAGAPDKVRKHGPQLLTAMINAMDDREDPEHI-VTQEAMSSLCLLLPYVQEKDI 1445

  Fly  1539 EPFHVSLAIRIRPFLGNYALEMREAAIQLFGDI---CEGKHDDGSSSPTSSMEALREQLIANLFP 1600
            ....:..|||:|||..:...|:|:|:|.|||::   |.|   :|:..     |...||:::.|..
Frog  1446 RSLLIHTAIRVRPFFDHEREELRKASISLFGNLIKFCSG---NGNGE-----EVFYEQMMSGLVA 1502

  Fly  1601 LLLHLSESEVAIASACRGTLQRVCRLLTAPRVVEMAEQQLGEERGHQLNYSSFVLEFVKTIALEL 1665
            |||||.:....:..||:..||.....:..|.:.:|....|..|||  |:|..|:....|.:....
Frog  1503 LLLHLQDPRADVVKACKFALQMCAPRMNNPSLADMFLSHLQPERG--LHYGEFMNNVCKHLLQGT 1565

  Fly  1666 TDHIQDFIDSCLPQLRSQWPEVRGSAAIVIGILHNFLSE---RNVQTETVASKIAVLLKDEQALV 1727
            .:.:...|.:.:...:|.||::|.:|.:.||.|...:.|   :.|..|.:.|.:.|||||....|
Frog  1566 PELLSRLIQTNVSYFKSIWPDIRAAAPLFIGFLVLHMQEDQTKQVDLEHLVSSLIVLLKDPHPPV 1630

  Fly  1728 RMRAATALG 1736
            |.||:..:|
Frog  1631 RARASETIG 1639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c11.1	NP_001285050.1	None
mroh1	XP_031760422.1	HEAT repeat	1325..1355	CDD:293787	7/29 (24%)
		HEAT repeat	1367..1391	CDD:293787	6/23 (26%)
		HEAT_EZ	1381..>1421	CDD:404407	8/39 (21%)
		HEAT repeat	1403..1438	CDD:293787	7/35 (20%)
		HEAT repeat	1448..1486	CDD:293787	15/40 (38%)
		HEAT repeat	1568..1604	CDD:293787	9/35 (26%)
		HEAT repeat	1614..1644	CDD:293787	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I661
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H44882
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1780
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19783at33208
OrthoFinder	1	1.000	-	-		FOG0005807
OrthoInspector	1	1.000	-	-		oto104802
Panther	1	1.100	-	-	LDO	PTHR23120
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160