DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment c12.1 and cwc15

DIOPT Version :9

Sequence 1:	NP_652605.1	Gene:	c12.1 / 53435	FlyBaseID:	FBgn0040235	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001072201.1	Gene:	cwc15 / 779647	XenbaseID:	XB-GENE-987018	Length:	227	Species:	Xenopus tropicalis

Alignment Length:	263	Identity:	147/263 - (55%)
Similarity:	174/263 - (66%)	Gaps:	40/263 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTAARPTFDPARGGSGRGEKDLSALSKQYSSRDLPGHTKLKYRETGQGTSDENRNRDFRKELEE 65
            |||||||||:|||||.|:||.|||.|||||||||||.|||:|||:..|...:|.|:||||:||||
Frog     1 MTTAARPTFEPARGGRGKGEADLSQLSKQYSSRDLPSHTKIKYRQATQDAPEEVRSRDFRRELEE 65

  Fly    66 REREARSGTGATSSSSGKALPSIVRKAIEANNAGGGSSAAKRSKPDAGQQQAQQAAQQQAANMDA 130
            |||.|                 :..|..:.......||.:|:.:.|          |..|||:||
Frog    66 RERVA-----------------VREKNRDRPTREHASSVSKKPRLD----------QIPAANLDA 103

  Fly   131 DEPL-DNDS-SDSDSDSDDDDAALLAELQKIKQERLQETARRESEKKQEDERIRMENILSGNPLM 193
            |:|| |.|: .|||.|||||.|||||||:|||:||.:|.||:|.|:|.|:||||||||||||||:
Frog   104 DDPLTDEDADDDSDEDSDDDTAALLAELEKIKKERAEEQARKELEQKAEEERIRMENILSGNPLL 168

  Fly   194 NYEPGTAASAAGRASGLGGDLKIKRRWDDDVVFKNCARSAPD--KKTHFVNDALRSDFHKKFMDK 256
            |. .|.|.|.|.        .|:||||||||||||||:...:  |...||||.|||:||||||:|
Frog   169 NL-TGPAQSVAA--------FKVKRRWDDDVVFKNCAKGVDEMKKDKRFVNDTLRSEFHKKFMEK 224

  Fly   257 YIK 259
            |||
Frog   225 YIK 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c12.1	NP_652605.1	Cwf_Cwc_15	1..258	CDD:282713	144/260 (55%)
cwc15	NP_001072201.1	Cwf_Cwc_15	1..226	CDD:368177	144/260 (55%)
cwc15	NP_001072201.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..130		80/155 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2028
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9499
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3118
OMA	1	1.010	-	-		QHG57716
OrthoDB	1	1.010	-	-		D1576404at2759
OrthoFinder	1	1.000	-	-		FOG0004833
OrthoInspector	1	1.000	-	-		oto102331
Panther	1	1.100	-	-	LDO	PTHR12718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R266
SonicParanoid	1	1.000	-	-		X3414
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110