DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment c12.1 and cwc15

DIOPT Version :9

Sequence 1:	NP_652605.1	Gene:	c12.1 / 53435	FlyBaseID:	FBgn0040235	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_001002050.2	Gene:	cwc15 / 415140	ZFINID:	ZDB-GENE-040625-10	Length:	244	Species:	Danio rerio

Alignment Length:	279	Identity:	153/279 - (54%)
Similarity:	181/279 - (64%)	Gaps:	55/279 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTAARPTFDPARGGSGRGEKDLSALSKQYSSRDLPGHTKLKYRETGQGTSDENRNRDFRKELEE 65
            |||||||||:|||||.|:||.|||||||||||||||||||:|||:..|...:|.|.||||:||||
Zfish     1 MTTAARPTFEPARGGRGKGEGDLSALSKQYSSRDLPGHTKIKYRQPTQDAPEEVRARDFRRELEE 65

  Fly    66 REREARSG--TGA----TSSSSGKALPSIVRKAIEANNAGGGSSAAKRSKPDAGQQQAQQAAQQQ 124
            |||.|..|  .||    |||||..:                 ||::||.:.|          |..
Zfish    66 RERAAVKGRDRGAREHTTSSSSSSS-----------------SSSSKRPRLD----------QIP 103

  Fly   125 AANMDADEPL--DNDSSDSDSDSDDDDAALLAELQKIKQERLQETARRESEKKQEDERIRMENIL 187
            |||:|||:||  |.|.|.||||||||.|||||||:|||:||.:|..|:|.|:|.|:|||||||||
Zfish   104 AANLDADDPLTDDEDDSGSDSDSDDDTAALLAELEKIKKERAEEQERKEREQKAEEERIRMENIL 168

  Fly   188 SGNPLMNYEPGTAASAAG----------RASGLGGDLKIKRRWDDDVVFKNCARSAPD--KKTHF 240
            |||||:|        .||          :.:.......:||||||||||||||:...:  |:..|
Zfish   169 SGNPLLN--------LAGQQQQQQQQQQQQTQTKNTFSVKRRWDDDVVFKNCAKGVDESRKEKRF 225

  Fly   241 VNDALRSDFHKKFMDKYIK 259
            |||.|||:||||||:||:|
Zfish   226 VNDTLRSEFHKKFMEKYVK 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c12.1	NP_652605.1	Cwf_Cwc_15	1..258	CDD:282713	151/276 (55%)
cwc15	NP_001002050.2	Cwf_Cwc_15	1..243	CDD:282713	151/276 (55%)
cwc15	NP_001002050.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..159		104/184 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580232
Domainoid	1	1.000	260	1.000	Domainoid score	I1941
eggNOG	1	0.900	-	-		E1_KOG3228
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9499
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3108
OMA	1	1.010	-	-		QHG57716
OrthoDB	1	1.010	-	-		D1576404at2759
OrthoFinder	1	1.000	-	-		FOG0004833
OrthoInspector	1	1.000	-	-		oto41579
orthoMCL	1	0.900	-	-		OOG6_102825
Panther	1	1.100	-	-	LDO	PTHR12718
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R266
SonicParanoid	1	1.000	-	-		X3414
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800