Protein Alignment c12.2 and REA1

DIOPT Version :9

• Sequence 1: NP_001259381.1
• Gene: c12.2 / 53434
• FlyBaseID: FBgn0040234
• Length: 1403
• Species: Drosophila melanogaster
• Sequence 2: NP_013207.1
• Gene: REA1 / 850796
• SGDID: S000004096
• Length: 4910
• Species: Saccharomyces cerevisiae
• Alignment Length: 1729
• Identity: 331/1729 - (19%)
• Similarity: 573/1729 - (33%)
• Gaps: 598/1729 - (34%)

  Fly    27 WASTTA-GKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYAS--DG 88
            ||...| |.:|.......:  ::.|.|.|::...|.:......::|...|      ..|||  |.
Yeast  1277 WALRDAVGYEQLAASGYML--LAERCRTPQEKVTVKKTLEKVMKVKLDMD------QYYASLEDK 1333

  Fly    89 TLQLSQSALHHLRW--------MLQKDAL--RQDMFLLGQPGPLRR---QLAMQFL--EL----- 133
            :|:    |:..:.|        :|....|  ::.:.|:|:.|..:.   ||..||:  ||
Yeast  1334 SLE----AIGSVTWTKGMRRLSVLVSSCLKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNA 1394

  Fly   134 -----------TQR------EVEY-----------VALSRDTTESDLKQRREINDRAAI------ 164
                       .||      |::|           :|..:|....:|.|....:|...|
Yeast  1395 HQNTETGDILGAQRPVRNRSEIQYKLIKSLKTALNIANDQDVDLKELLQLYSKSDNKNIAEDVQL 1459

  Fly   165 --------------FHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMS 215
                          :.|...::|...|...:||.:..|:.:||..||::||
Yeast  1460 EIQKLRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLE-------------- 1510

  Fly   216 PERYDKLLEKHSREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGE 280
            |||...|.|:.|.:     .|:..||.|:..|...|...|....|.|.||:||....|.:.   |
Yeast  1511 PERSLLLAEQGSSD-----SLVTASENFQFFATMNPGGDYGKKELSPALRNRFTEIWVPSM---E 1567

  Fly   281 LYEELQQEAPSVPGEQLKQLLTFALTLQQADPVLQLPDFPIHNLALGVKMLAANPS---LSLHDV 342
            .:.::.....|...|.||.|         |:|:::..::      .|.|:...|.:   :||.|:
Yeast  1568 DFNDVNMIVSSRLLEDLKDL---------ANPIVKFSEW------FGKKLGGGNATSGVISLRDI 1617

  Fly   343 ------ISRIYP-----------------------YQTMLKPDQKKRVEELLKKLDIQLVPSPSI 378
                  |::::|                       ..|....:.:..::.|..:..|||:....
Yeast  1618 LAWVEFINKVFPKIQNKSTALIQGASMVFIDALGTNNTAYLAENENDLKSLRTECIIQLLKLCG- 1681

  Fly   379 KKIEAQSQENSLIHIKLDELQLNL------PEGQIPTASTYFVDLPHQRQALASLLQAYAV-GDV 436
            ..:|.|..|.:.|.:..||||:.:      |:.|   :|::.:..|.....|..:::|..| ..:
Yeast  1682 DDLELQQIETNEIIVTQDELQVGMFKIPRFPDAQ---SSSFNLTAPTTASNLVRVVRAMQVHKPI 1743

  Fly   437 CLVGEKGVGKLTLTQEL----------LRLLQQTSEPMMLYEDMTSRDIVQQRITSPQGDTVWRD 491
            .|.|..||||.:|...|          :.|.:||.     ..|:...|...:|    .|:.:|.|
Yeast  1744 LLEGSPGVGKTSLITALANITGNKLTRINLSEQTD-----LVDLFGADAPGER----SGEFLWHD 1799

  Fly   492 SPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIHDRELQLCDGTTLLGANRYQALLQQGFSKEEL 556
            :|.:||.|.|...:|:.::...:|....|...:..|            ...|...|...||
Yeast  1800 APFLRAMKKGEWVLLDEMNLASQSVLEGLNACLDHR------------GEAYIPELDISFS---- 1848

  Fly   557 GKLGFLPIHESFRVVALAEPPRLGGGQP---------------SWLTPE---LLSLFLYQELRPL 603
                   .|.:|.|.|...|...|||:.               ..||.:   |::..||..:.|
Yeast  1849 -------CHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLTSDDLLLIAKHLYPSIEP- 1905

  Fly   604 RQSEEAELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPL----LQGLAGT---LSTRQLLKLARRL 661
                                 |.:.|:.:|:.:.:|.:    |.|.:|:   .:.|..|:..:.|
Yeast  1906 ---------------------DIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLL 1949

  Fly   662 AAYPESELSDVHEMLQNTFLARFMPALSRGALEQAIQQV-GIKPREIKLKSKKN----------- 714
            ..|...|..||.:.:......||.....:...:..|:.: |      |..:|:|
Yeast  1950 NQYSICEDVDVFDFVDIIVKQRFRTISDKNKAQLLIEDIFG------KFSTKENFFKLTEDYVQI 2008

  Fly   715 ------------------------QIAVEDNSLRIGSTRWPL---GNPTQAQLSKV--------P 744
                                    .:||.::.|:..:..|||   |.....:...:        |
Yeast  2009 NNEVALRNPHYRYPITQNLFPLECNVAVYESVLKAINNNWPLVLVGPSNSGKTETIRFLASILGP 2073

  Fly   745 HTLFYEMPQHVQLLERLLQDY----------LIGEHLLLVGNQGVGKN--------------KLV 785
            ....:.|...:..:: :|..|          .|.|.|..:..:.:..|              .|:
Yeast  2074 RVDVFSMNSDIDSMD-ILGGYEQVDLTRQISYITEELTNIVREIISMNMKLSPNATAIMEGLNLL 2137

  Fly   786 DRLLELMQRPREY-------------IQLHRDTTVHSLTL----QATLKDGQVSYE--DSALVQA 831
            ..||..:..|.::             ::.|......|:.:    :...|:..|.:|  |..||:|
Yeast  2138 KYLLNNIVTPEKFQDFRNRFNRFFSHLEGHPLLKTMSMNIEKMTEIITKEASVKFEWFDGMLVKA 2202

  Fly   832 VRTGHVLVVDEADKAPVNVTCILRTLVE-SGEMVLADGRRIVPPGEGGRVPNSIETHPDFRLIV- 894
            |..||.|::|.|:....:|...|.:|:| .|.:::.:..:     |.|: |..::.||:|||.:
Yeast  2203 VEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINECSQ-----EDGQ-PRVLKPHPNFRLFLT 2261

  Fly   895 -----------LANRP--------------------GFPFLGNDFFAALGDVFSCHAISNPDPES 928
                       :.||.                    ||....|..|.::.|......::.||..
Yeast  2262 MDPKYGELSRAMRNRGVEIYIDELHSRSTAFDRLTLGFELGENIDFVSIDDGIKKIKLNEPDMS- 2325

  Fly   929 EIFLLQQYGPKVPIKTLRTLVNA-FGELRTLADEGMLNYPYSTREVVSIVKHLERYPEENMSEV- 991
              ..|:.|   ||....|..:.| ..::..|:||..:.     ..:.:::      |..::.||
Yeast  2326 --IPLKHY---VPSYLSRPCIFAQVHDILLLSDEEPIE-----ESLAAVI------PISHLGEVG 2374

  Fly   992 --VGNVLDFDRYQPEALQQVTQVLAKHGIESYAEEEIQAIRKQRILQASVNRHSGLGVSGPKFGK 1054
              ..|||:...|..:.:.:...|......:....|:|..:.|...|               ||.|
Yeast  2375 KWANNVLNCTEYSEKKIAERLYVFITFLTDMGVLEKINNLYKPANL---------------KFQK 2424

  Fly  1055 LDPKNEPHVGGNTWAGGSGGRDTAGLGGKGGPFRLDKGHKVHQLSDE------------------ 1101
                                  ..||..|             ||::|
Yeast  2425 ----------------------ALGLHDK-------------QLTEETVSLTLNEYVLPTVSKYS 2454

  Fly  1102 EKADVPEEI------------KRAAREMNRKAFEDKLKE---IKMSAHDHKLYAQFSEPNRKQVQ 1151
            :|...||.:            ..|.:.:|.|:...|:.|   |::||      |.|:..:.|.:.
Yeast  2455 DKIKSPESLYLLSSLRLLLNSLNALKLINEKSTHGKIDELTYIELSA------AAFNGRHLKNIP 2513

  Fly  1152 Q----------LKAVLEAMQTKSKERQWQKYQTHGDL--------------DDTRLVEGITGEKN 1192
            :          |..:.|.::|:|......:||.:.||              |:.||        .
Yeast  2514 RIPIFCILYNILTVMSENLKTESLFCGSNQYQYYWDLLVIVIAALETAVTKDEARL--------R 2570

  Fly  1193 IYRRRAEANPWADHVQEKPNRLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVMEAFEGFEKKIVY 1257
            :|:...::  |...|:.|.       |:..:.:        |:..|| ...|::...|....:::
Yeast  2571 VYKELIDS--WIASVKSKS-------DIEITPF--------LNINLE-FTDVLQLSRGHSITLLW 2617

  Fly  1258 DIIGH----SGEGWEIPFVTAGSPPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAE 1318
            ||...    :...|     .|.....|..|:|:.:|::    ||..|.:| :|...:....|.
Yeast  2618 DIFRKNYPTTSNSW-----LAFEKLINLSEKFDKVRLL----QFSESYNS-IKDLMDVFRLLN-- 2670

  Fly  1319 QDYDNAIVVVLSDANL----QRYGIAPKDLAMALKRGEPKVKGYAIFIGSLAEEAD--------- 1370
               |:.:...||:.||    ...||  .:|.:...:...|.|.|      .|:|.|
Yeast  2671 ---DDVLNNKLSEFNLLLSKLEDGI--NELELISNKFLNKRKHY------FADEFDNLIRYTFSV 2724

  Fly  1371 ---EINAEMPAGQSFVCMDLTKL-------PHILQQIFT 1399
               |:..|:....|.....||||       |.|...::|
Yeast  2725 DTAELIKELAPASSLATQKLTKLITNKYNYPPIFDVLWT 2763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:285029	48/213 (23%)
		AAA_5	435..595	CDD:285029	41/187 (22%)
		AAA_5	770..916	CDD:285029	41/211 (19%)
		vWA_F11C1-5a_type	1212..1403	CDD:238732	44/215 (20%)
REA1	NP_013207.1	MDN1	89..4910	CDD:227596	331/1729 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5271
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810