DRSC/TRiP Functional Genomics Resources

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Protein Alignment c12.2 and REA1

DIOPT Version :10

Sequence 1:NP_001259381.1 Gene:c12.2 / 53434 FlyBaseID:FBgn0040234 Length:1403 Species:Drosophila melanogaster
Sequence 2:NP_013207.1 Gene:REA1 / 850796 SGDID:S000004096 Length:4910 Species:Saccharomyces cerevisiae


Alignment Length:1729 Identity:331/1729 - (19%)
Similarity:573/1729 - (33%) Gaps:598/1729 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 WASTTA-GKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYAS--DG 88
            ||...| |.:|.......:  ::.|.|.|::...|.:......::|...|      ..|||  |.
Yeast  1277 WALRDAVGYEQLAASGYML--LAERCRTPQEKVTVKKTLEKVMKVKLDMD------QYYASLEDK 1333

  Fly    89 TLQLSQSALHHLRW--------MLQKDAL--RQDMFLLGQPGPLRR---QLAMQFL--EL----- 133
            :|:    |:..:.|        :|....|  ::.:.|:|:.|..:.   ||..||:  ||     
Yeast  1334 SLE----AIGSVTWTKGMRRLSVLVSSCLKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNA 1394

  Fly   134 -----------TQR------EVEY-----------VALSRDTTESDLKQRREINDRAAI------ 164
                       .||      |::|           :|..:|....:|.|....:|...|      
Yeast  1395 HQNTETGDILGAQRPVRNRSEIQYKLIKSLKTALNIANDQDVDLKELLQLYSKSDNKNIAEDVQL 1459

  Fly   165 --------------FHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMS 215
                          :.|...::|...|...:||.:..|:.:||..||::||              
Yeast  1460 EIQKLRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLE-------------- 1510

  Fly   216 PERYDKLLEKHSREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGE 280
            |||...|.|:.|.:     .|:..||.|:..|...|...|....|.|.||:||....|.:.   |
Yeast  1511 PERSLLLAEQGSSD-----SLVTASENFQFFATMNPGGDYGKKELSPALRNRFTEIWVPSM---E 1567

  Fly   281 LYEELQQEAPSVPGEQLKQLLTFALTLQQADPVLQLPDFPIHNLALGVKMLAANPS---LSLHDV 342
            .:.::.....|...|.||.|         |:|:::..::      .|.|:...|.:   :||.|:
Yeast  1568 DFNDVNMIVSSRLLEDLKDL---------ANPIVKFSEW------FGKKLGGGNATSGVISLRDI 1617

  Fly   343 ------ISRIYP-----------------------YQTMLKPDQKKRVEELLKKLDIQLVPSPSI 378
                  |::::|                       ..|....:.:..::.|..:..|||:.... 
Yeast  1618 LAWVEFINKVFPKIQNKSTALIQGASMVFIDALGTNNTAYLAENENDLKSLRTECIIQLLKLCG- 1681

  Fly   379 KKIEAQSQENSLIHIKLDELQLNL------PEGQIPTASTYFVDLPHQRQALASLLQAYAV-GDV 436
            ..:|.|..|.:.|.:..||||:.:      |:.|   :|::.:..|.....|..:::|..| ..:
Yeast  1682 DDLELQQIETNEIIVTQDELQVGMFKIPRFPDAQ---SSSFNLTAPTTASNLVRVVRAMQVHKPI 1743

  Fly   437 CLVGEKGVGKLTLTQEL----------LRLLQQTSEPMMLYEDMTSRDIVQQRITSPQGDTVWRD 491
            .|.|..||||.:|...|          :.|.:||.     ..|:...|...:|    .|:.:|.|
Yeast  1744 LLEGSPGVGKTSLITALANITGNKLTRINLSEQTD-----LVDLFGADAPGER----SGEFLWHD 1799

  Fly   492 SPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIHDRELQLCDGTTLLGANRYQALLQQGFSKEEL 556
            :|.:||.|.|...:|:.::...:|....|...:..|            ...|...|...||    
Yeast  1800 APFLRAMKKGEWVLLDEMNLASQSVLEGLNACLDHR------------GEAYIPELDISFS---- 1848

  Fly   557 GKLGFLPIHESFRVVALAEPPRLGGGQP---------------SWLTPE---LLSLFLYQELRPL 603
                   .|.:|.|.|...|...|||:.               ..||.:   |::..||..:.| 
Yeast  1849 -------CHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLTSDDLLLIAKHLYPSIEP- 1905

  Fly   604 RQSEEAELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPL----LQGLAGT---LSTRQLLKLARRL 661
                                 |.:.|:.:|:.:.:|.:    |.|.:|:   .:.|..|:..:.|
Yeast  1906 ---------------------DIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLL 1949

  Fly   662 AAYPESELSDVHEMLQNTFLARFMPALSRGALEQAIQQV-GIKPREIKLKSKKN----------- 714
            ..|...|..||.:.:......||.....:...:..|:.: |      |..:|:|           
Yeast  1950 NQYSICEDVDVFDFVDIIVKQRFRTISDKNKAQLLIEDIFG------KFSTKENFFKLTEDYVQI 2008

  Fly   715 ------------------------QIAVEDNSLRIGSTRWPL---GNPTQAQLSKV--------P 744
                                    .:||.::.|:..:..|||   |.....:...:        |
Yeast  2009 NNEVALRNPHYRYPITQNLFPLECNVAVYESVLKAINNNWPLVLVGPSNSGKTETIRFLASILGP 2073

  Fly   745 HTLFYEMPQHVQLLERLLQDY----------LIGEHLLLVGNQGVGKN--------------KLV 785
            ....:.|...:..:: :|..|          .|.|.|..:..:.:..|              .|:
Yeast  2074 RVDVFSMNSDIDSMD-ILGGYEQVDLTRQISYITEELTNIVREIISMNMKLSPNATAIMEGLNLL 2137

  Fly   786 DRLLELMQRPREY-------------IQLHRDTTVHSLTL----QATLKDGQVSYE--DSALVQA 831
            ..||..:..|.::             ::.|......|:.:    :...|:..|.:|  |..||:|
Yeast  2138 KYLLNNIVTPEKFQDFRNRFNRFFSHLEGHPLLKTMSMNIEKMTEIITKEASVKFEWFDGMLVKA 2202

  Fly   832 VRTGHVLVVDEADKAPVNVTCILRTLVE-SGEMVLADGRRIVPPGEGGRVPNSIETHPDFRLIV- 894
            |..||.|::|.|:....:|...|.:|:| .|.:::.:..:     |.|: |..::.||:|||.: 
Yeast  2203 VEKGHWLILDNANLCSPSVLDRLNSLLEIDGSLLINECSQ-----EDGQ-PRVLKPHPNFRLFLT 2261

  Fly   895 -----------LANRP--------------------GFPFLGNDFFAALGDVFSCHAISNPDPES 928
                       :.||.                    ||....|..|.::.|......::.||.. 
Yeast  2262 MDPKYGELSRAMRNRGVEIYIDELHSRSTAFDRLTLGFELGENIDFVSIDDGIKKIKLNEPDMS- 2325

  Fly   929 EIFLLQQYGPKVPIKTLRTLVNA-FGELRTLADEGMLNYPYSTREVVSIVKHLERYPEENMSEV- 991
              ..|:.|   ||....|..:.| ..::..|:||..:.     ..:.:::      |..::.|| 
Yeast  2326 --IPLKHY---VPSYLSRPCIFAQVHDILLLSDEEPIE-----ESLAAVI------PISHLGEVG 2374

  Fly   992 --VGNVLDFDRYQPEALQQVTQVLAKHGIESYAEEEIQAIRKQRILQASVNRHSGLGVSGPKFGK 1054
              ..|||:...|..:.:.:...|......:....|:|..:.|...|               ||.|
Yeast  2375 KWANNVLNCTEYSEKKIAERLYVFITFLTDMGVLEKINNLYKPANL---------------KFQK 2424

  Fly  1055 LDPKNEPHVGGNTWAGGSGGRDTAGLGGKGGPFRLDKGHKVHQLSDE------------------ 1101
                                  ..||..|             ||::|                  
Yeast  2425 ----------------------ALGLHDK-------------QLTEETVSLTLNEYVLPTVSKYS 2454

  Fly  1102 EKADVPEEI------------KRAAREMNRKAFEDKLKE---IKMSAHDHKLYAQFSEPNRKQVQ 1151
            :|...||.:            ..|.:.:|.|:...|:.|   |::||      |.|:..:.|.:.
Yeast  2455 DKIKSPESLYLLSSLRLLLNSLNALKLINEKSTHGKIDELTYIELSA------AAFNGRHLKNIP 2513

  Fly  1152 Q----------LKAVLEAMQTKSKERQWQKYQTHGDL--------------DDTRLVEGITGEKN 1192
            :          |..:.|.::|:|......:||.:.||              |:.||        .
Yeast  2514 RIPIFCILYNILTVMSENLKTESLFCGSNQYQYYWDLLVIVIAALETAVTKDEARL--------R 2570

  Fly  1193 IYRRRAEANPWADHVQEKPNRLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVMEAFEGFEKKIVY 1257
            :|:...::  |...|:.|.       |:..:.:        |:..|| ...|::...|....:::
Yeast  2571 VYKELIDS--WIASVKSKS-------DIEITPF--------LNINLE-FTDVLQLSRGHSITLLW 2617

  Fly  1258 DIIGH----SGEGWEIPFVTAGSPPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAE 1318
            ||...    :...|     .|.....|..|:|:.:|::    ||..|.:| :|...:....|.  
Yeast  2618 DIFRKNYPTTSNSW-----LAFEKLINLSEKFDKVRLL----QFSESYNS-IKDLMDVFRLLN-- 2670

  Fly  1319 QDYDNAIVVVLSDANL----QRYGIAPKDLAMALKRGEPKVKGYAIFIGSLAEEAD--------- 1370
               |:.:...||:.||    ...||  .:|.:...:...|.|.|      .|:|.|         
Yeast  2671 ---DDVLNNKLSEFNLLLSKLEDGI--NELELISNKFLNKRKHY------FADEFDNLIRYTFSV 2724

  Fly  1371 ---EINAEMPAGQSFVCMDLTKL-------PHILQQIFT 1399
               |:..|:....|.....||||       |.|...::|
Yeast  2725 DTAELIKELAPASSLATQKLTKLITNKYNYPPIFDVLWT 2763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c12.2NP_001259381.1 AAA_5 112..268 CDD:400191 48/213 (23%)
AAA_5 435..595 CDD:400191 41/187 (22%)
AAA_5 770..916 CDD:400191 41/211 (19%)
vWA_F11C1-5a_type 1212..1403 CDD:238732 44/215 (20%)
REA1NP_013207.1 P-loop containing Nucleoside Triphosphate Hydrolases 310..427 CDD:476819
AAA_lid_7 465..579 CDD:465540
P-loop containing Nucleoside Triphosphate Hydrolases 648..>703 CDD:476819
P-loop containing Nucleoside Triphosphate Hydrolases <811..896 CDD:476819
AAA_lid_5 910..1015 CDD:407722
P-loop containing Nucleoside Triphosphate Hydrolases 1078..1214 CDD:476819
AAA_lid_7 1226..1320 CDD:465540 9/44 (20%)
P-loop containing Nucleoside Triphosphate Hydrolases 1363..1558 CDD:476819 48/213 (23%)
P-loop containing Nucleoside Triphosphate Hydrolases 1742..1879 CDD:476819 38/168 (23%)
AAA_lid_7 1891..1990 CDD:465540 21/120 (18%)
P-loop containing Nucleoside Triphosphate Hydrolases <2190..2276 CDD:476819 25/91 (27%)
MDN1 <4046..4671 CDD:444083
vWA_midasin 4643..4910 CDD:238737
Blue background indicates that the domain is not in the aligned region.

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