DRSC/TRiP Functional Genomics Resources

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Protein Alignment c12.2 and vwa8

DIOPT Version :9

Sequence 1:NP_001259381.1 Gene:c12.2 / 53434 FlyBaseID:FBgn0040234 Length:1403 Species:Drosophila melanogaster
Sequence 2:NP_001121810.1 Gene:vwa8 / 561317 ZFINID:ZDB-GENE-070912-407 Length:1896 Species:Danio rerio


Alignment Length:1912 Identity:719/1912 - (37%)
Similarity:969/1912 - (50%) Gaps:568/1912 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 CSGH---LLHHSLRNARIPRRSWASTTAGKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSR 69
            ||.|   ||               :|::|      |::.||::|..|:.||:|:|||.       
Zfish    34 CSAHEVKLL---------------NTSSG------DTVKIGEISYVLKTPKNPELVPV------- 70

  Fly    70 IKETTDLKRRNELKYASDGTLQLSQSALHHLRWMLQKDALRQDMFLLGQPGPLRRQLAMQFLELT 134
                      |.:..|      |.|....||||::|||.|.||:||:|.||||||.:|||:||||
Zfish    71 ----------NHMMEA------LPQMVTQHLRWIMQKDLLGQDVFLIGPPGPLRRSIAMQYLELT 119

  Fly   135 QREVEYVALSRDTTESDLKQRREINDRAAIFHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNL 199
            :||||||||||||||:||||||||....|.:.||.|||||..||:|||:|:|.|||||||:||||
Zfish   120 KREVEYVALSRDTTETDLKQRREIRSGTAFYIDQCAVRAATEGRILVLEGLEKAERNVLPVLNNL 184

  Fly   200 LENREMHLESGKFLMSPERYDKLLEKHSREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPL 264
            ||||||.||.|:||||..|||||||:|::|:||.|.::||||.|||:|||||..:|||.||||||
Zfish   185 LENREMQLEDGRFLMSAHRYDKLLEEHTKEELDAWKIVRVSEDFRVIALGLPVPRYKGNPLDPPL 249

  Fly   265 RSRFQSRNVTTYSYGELYEELQQEAPSVPGEQLKQLLTFALTL-QQADPVLQLPDFPIHNLALGV 328
            |||||:|::....:.:..|.|.:...:|..|::.|||:||.|| .|....|.|||||:.||...:
Zfish   250 RSRFQARDIYYLPFKDQLEHLYRIGANVSAERVSQLLSFATTLCSQESASLSLPDFPVDNLPSAL 314

  Fly   329 KMLAANPSLSLHDVISRIYPYQTMLKPDQKKRVEELLKKLDI---QLVPSP----SIKKIEAQSQ 386
            .:|...|.||:..::.|:|||:.||..:.:..||.:|.:.::   ...|||    :|:.:.....
Zfish   315 TVLNLFPMLSVQQLVQRLYPYEAMLGKEGRTAVEGVLNRFELTDGSTKPSPTAVVNIEPVNGGQA 379

  Fly   387 ENSLIHIKL--DELQLNLPEG----QIPTASTYFVDLPHQRQALASLLQAYAVGDVCLVGEKGVG 445
            |.:.:.:.:  .::...:|.|    :.|.:|..|::.|...:.||.::|::.|.|:||:|.||.|
Zfish   380 EQAAVTLNITNQKITFQVPSGTRPIRPPNSSPTFINTPTHERLLAEMMQSHLVKDICLIGAKGCG 444

  Fly   446 KLTLTQELLRLLQQTSEPMMLYEDMTSRDIVQQRITSPQGDTVWRDSPLVRAAKSGSVAVLNGLH 510
            |..:.:|...:|..:.||:|||:|||:||::|||.|.|.|||.||.||||.||:.|.:.:|:|:|
Zfish   445 KSVIAREFAEMLGYSIEPVMLYQDMTARDLLQQRYTLPNGDTAWRASPLVTAAQEGKLVLLDGIH 509

  Fly   511 RLHKSTASVLQRLIHDRELQLCDGTTLLGANRYQALLQQ-GFSKEELGKLGFLPIHESFRVVALA 574
            |::..|.:||.||:|||||.|.|||.||..:|||||.:: ..:.::|......|||.|||::|||
Zfish   510 RVNLGTLAVLSRLLHDRELDLYDGTRLLRFDRYQALKEELQLTDQQLQDRSIFPIHPSFRIIALA 574

  Fly   575 EPPRLGGGQPSWLTPELLSLFLYQELRPLRQSEEAELLAQLCGGDLPAGMDQLLKLAQLLRSSQD 639
            |||.:|.....||.||:|::||:..::||.::||..:|..:........::||..|...||.|.|
Zfish   575 EPPVIGSTTQQWLNPEILTMFLFHTIKPLAKAEETAVLQGMIPNVPGEAVEQLQHLTHSLRKSND 639

  Fly   640 PLLQGLAGTLSTRQLLKLARRLAAYP-ESELSDVHEMLQNTFLARFMPALSRGALEQAIQQVGIK 703
            |....||.:|||||||::.|||:.|| ||....||:    ..|:||:|:|:|.:||:::....|:
Zfish   640 PTALSLASSLSTRQLLRICRRLSQYPQESVAHAVHK----ACLSRFLPSLARSSLEKSLANCSIE 700

  Fly   704 PREIKLKSKKN--QIAVEDNSLRIGSTRWPLGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYL 766
            ........:|.  ...|:|..|.||:...|:.:|.:..  |||..||||..||:.:::.:|:|:|
Zfish   701 DHPDPASEQKQLYTCTVKDGLLTIGNVSAPVYSPDEKM--KVPDVLFYENVQHMMVMQDMLKDFL 763

  Fly   767 IGEHLLLVGNQGVGKNKLVDRLLELMQRPREYIQLHRDTTVHSLTLQATLKDGQVSYEDSALVQA 831
            :||||||||||||||||:|||.|.||.|||||:||||||||.:||||.:::||.:.||||.||:|
Zfish   764 LGEHLLLVGNQGVGKNKIVDRFLHLMNRPREYLQLHRDTTVQTLTLQPSVRDGIIIYEDSPLVKA 828

  Fly   832 VRTGHVLVVDEADKAPVNVTCILRTLVESGEMVLADGRRIVPPG-EGGRVPNSIETHPDFRLIVL 895
            |:.||:||:|||||||.||||||:.|||||||:||||||||... |....||:|..|||||:|||
Zfish   829 VKMGHILVIDEADKAPTNVTCILKALVESGEMILADGRRIVSDALEAAGRPNAIPMHPDFRMIVL 893

  Fly   896 ANRPGFPFLGNDFFAALGDVFSCHAISNPDPESEIFLLQQYGPKVPIKTLRTLVNAFGELRTLAD 960
            ||||||||||||||.||||:|||||:.||.|::|..:|:||||.||...|:.||.||||||.:||
Zfish   894 ANRPGFPFLGNDFFGALGDIFSCHAVDNPKPQAEFAMLKQYGPDVPDAVLQKLVAAFGELRAMAD 958

  Fly   961 EGMLNYPYSTREVVSIVKHLERYPEENMSEVVGNVLDFDRYQPEALQQVTQVLAKHGIE------ 1019
            :|.:.|||||||||:|||||:::|:|.::.||.||.|||.|..:..:.:...|.||||.      
Zfish   959 QGTITYPYSTREVVNIVKHLQKFPDEGLANVVRNVFDFDSYNKDMREVLISALHKHGIPIGAKPT 1023

  Fly  1020 ---------------------------------------------------------------SY 1021
                                                                           |:
Zfish  1024 SVHLAKELPLPDCKMTGYWTISQGGNTRRKLLCPTETHRIDIKGPVFLRVQSYPSKRHESRSLSF 1088

  Fly  1022 AEEE------------------------------------------------------------- 1025
            .||:                                                             
Zfish  1089 TEEQAHWQIPMNEVNIVCDVTTAKDSIYVATCNPVSLYAMKEKGDSVQCIELYDIFPRTISGVWQ 1153

  Fly  1026 ----------------------------------------------------------------- 1025
                                                                             
Zfish  1154 PFVSVAALGNPLQDQVVLHEEQGNTVLHLDLVTGAVRRLILSQDKQDEAPRKTSNWWNSKESQPG 1218

  Fly  1026 ----------------------------------------------------------------- 1025
                                                                             
Zfish  1219 YKMCKEFAHKNWLLFYKENGNQLDVVDVLEGQVHTIHLPINLKAVFLVAEDRWLLVESKTDRKFL 1283

  Fly  1026 ----------------------------------IQAIRKQRI---------------------- 1034
                                              ::|:..|.:                      
Zfish  1284 LTKPMHMGAEETGVCQLHAISEDAVSSGFGNNSGMEAVSPQEVSSDQLSNENLSAALGQKIVSPN 1348

  Fly  1035 ----------------------------------------------------------------- 1034
                                                                             
Zfish  1349 RILCDTNTYANVIVGFPDLMSPNELYSFRRSLPITESRRPDMFFGSSKRTGPAKRVNCVCLLDAN 1413

  Fly  1035 ----------------------------------------------------------------- 1034
                                                                             
Zfish  1414 QVVRALPPTQVPLAEVYPKDVTPPMSAAYLEVTDLNSKRLKYIPVPRSNSMSPYTVWISKVSDTD 1478

  Fly  1035 ------------------------------------------------LQASVNRHSGLGVSGPK 1051
                                                            :|.::.|.|||.||.||
Zfish  1479 VVMAPLGSGGVVTVDMGGYVRLWETGLDHLQRSLLEWRNMIGSEDGRPVQITIERDSGLDVSSPK 1543

  Fly  1052 FGKLDPKNEPHVGGNTWAGGSGGRDTAGLGGKGGPFRLDKGHKVHQLSDEEKADVPEEIKRAARE 1116
            .||:|.||.||||||.||||:||||||||||||||:|||.||||:|:|..||..||:|:|||||:
Zfish  1544 HGKIDAKNAPHVGGNQWAGGTGGRDTAGLGGKGGPYRLDAGHKVYQISQAEKDAVPDEVKRAARD 1608

  Fly  1117 MNRKAFEDKLKEIKMSAHDHKLYAQFSEPNRKQVQQLKAVLEAMQTKSKERQWQKYQTHGDLDDT 1181
            |..:||:.:||||:||.:|...|.:||...|:|||.|:.:|:::|.|.|||||.:.|..|:|||.
Zfish  1609 MAEQAFKQRLKEIEMSEYDASTYDRFSGAVRRQVQSLRIILDSLQAKGKERQWLRNQALGELDDA 1673

  Fly  1182 RLVEGITGEKNIYRRRAEANPWADHVQEKPNRLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVME 1246
            ::::|:||||:||:||.|..|.....|:||.||:::.|||||||||||.||||:|.:|||.||||
Zfish  1674 KIIDGLTGEKSIYKRRGELEPELGSPQQKPKRLRVLADVSGSMYRFNGVDGRLERSMEAVCMVME 1738

  Fly  1247 AFEGFEKKIVYDIIGHSGEGWEIPFVTAGSPPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREA 1311
            |.|.:|.|..|||.||||:|::|..|.....|||:|||.:.::.||||||||.|||.|::....|
Zfish  1739 ALESYEHKFKYDITGHSGDGFDIELVRCDKVPKNNKERLKVLKTMHAHSQFCMSGDYTLEGTEHA 1803

  Fly  1312 CSTLGAEQDYDNAIVVVLSDANLQRYGIAPKDLAMALKRGEPKVKGYAIFIGSLAEEADEINAEM 1376
            ...| |.::.|...|:|||||||:||||:|...|..| ...|:|..:|||||||.::||.:...:
Zfish  1804 IREL-AHEEADEHFVIVLSDANLERYGISPDRFARVL-TSNPQVNAFAIFIGSLGDQADRLQKTL 1866

  Fly  1377 PAGQSFVCMDLTKLPHILQQIFTSSLL 1403
            |||:|||.||..::|.||||||||::|
Zfish  1867 PAGRSFVAMDTKEIPQILQQIFTSTML 1893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c12.2NP_001259381.1 AAA_5 112..268 CDD:285029 113/155 (73%)
AAA_5 435..595 CDD:285029 81/160 (51%)
AAA_5 770..916 CDD:285029 109/146 (75%)
vWA_F11C1-5a_type 1212..1403 CDD:238732 104/190 (55%)
vwa8NP_001121810.1 AAA_5 97..253 CDD:285029 113/155 (73%)
AAA_5 434..577 CDD:285029 73/142 (51%)
AAA_5 767..914 CDD:285029 109/146 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1536..1564 20/27 (74%)
vWFA 1704..1893 CDD:294047 104/190 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170579344
Domainoid 1 1.000 554 1.000 Domainoid score I241
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H44881
Inparanoid 1 1.050 1370 1.000 Inparanoid score I124
OMA 1 1.010 - - QHG56748
OrthoDB 1 1.010 - - D48751at33208
OrthoFinder 1 1.000 - - FOG0007423
OrthoInspector 1 1.000 - - oto40201
orthoMCL 1 0.900 - - OOG6_104715
Panther 1 1.100 - - LDO PTHR21610
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3032
SonicParanoid 1 1.000 - - X5558
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1413.940

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