DRSC/TRiP Functional Genomics Resources

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Protein Alignment c12.2 and Vwa8

DIOPT Version :9

Sequence 1:NP_001259381.1 Gene:c12.2 / 53434 FlyBaseID:FBgn0040234 Length:1403 Species:Drosophila melanogaster
Sequence 2:XP_038949970.1 Gene:Vwa8 / 290381 RGDID:1308772 Length:1905 Species:Rattus norvegicus


Alignment Length:1882 Identity:713/1882 - (37%)
Similarity:955/1882 - (50%) Gaps:552/1882 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 DSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYASDGTLQLSQSALHHLRWML 104
            :::.|||||.:|:.||:|:||||.|...|.                       |||.:.||||::
  Rat    55 ETVNIGDVSYKLKTPKNPELVPQNYIAASP-----------------------SQSVVQHLRWIM 96

  Fly   105 QKDALRQDMFLLGQPGPLRRQLAMQFLELTQREVEYVALSRDTTESDLKQRREINDRAAIFHDQG 169
            |||.|.||:||:|.||||||.:|||:||||::||||:||||||||:||||||||....|.:.||.
  Rat    97 QKDLLGQDVFLIGPPGPLRRSVAMQYLELTKQEVEYIALSRDTTETDLKQRREIRAGTAFYIDQC 161

  Fly   170 AVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMSPERYDKLLEKHSREQLDEW 234
            |||||..||.|||:|:|.|||||||:||||||||||.||.|:||||.|||||||..|::|:||.|
  Rat   162 AVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDHTKEELDAW 226

  Fly   235 GLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGELYEELQQEAPSVPGEQLKQ 299
            .::||||.|||:|||||..:|.|.|||||||||||:|::....:.:..:.|.....:|..|::.|
  Rat   227 KIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYFLPFQDQLKLLYSVGANVSAEKISQ 291

  Fly   300 LLTFALTL-QQADPVLQLPDFPIHNLALGVKMLAANPSLSLHDVISRIYPYQTMLKPDQKKRVEE 363
            ||:||.|| .|....|.|||||:.:|...|::|.:.|.:.:...|..:|||..:|..:.|..||.
  Rat   292 LLSFATTLCSQESSTLGLPDFPLDSLPEAVQILDSFPMMPIEHAIRWMYPYTVLLGHEGKMAVEG 356

  Fly   364 LLKKLDIQ-----LVPSPSIKKIEAQSQEN-SLIHIKL----DELQLNLPEG----QIPTASTYF 414
            :||:.::|     |:|. .|.::|..:..: |..|:.:    .|:.:.:|.|    ..|.|...|
  Rat   357 VLKRFELQGSGHSLLPK-EIVRVERMTDSHISHAHVTIRVSGKEVTIKVPAGTRAVNQPCAPDRF 420

  Fly   415 VDLPHQRQALASLLQAYAVGDVCLVGEKGVGKLTLTQELLRLLQQTSEPMMLYEDMTSRDIVQQR 479
            :.....:|.||.::|::.|.|:||:|.||.||..:.:....||..:.||:|||:|||:||::|||
  Rat   421 IQTVSHKQLLAEMMQSHMVKDICLIGGKGCGKTVMAKNFAALLGYSIEPIMLYQDMTARDLLQQR 485

  Fly   480 ITSPQGDTVWRDSPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIHDRELQLCDGTTLLGANRYQ 544
            .|.|.|||.||.||||.||:.|.:.:|:|:||::..|.:|||||||||||.|.||:.||..:||.
  Rat   486 YTLPNGDTAWRSSPLVSAAREGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYL 550

  Fly   545 ALLQQ-GFSKEELGKLGFLPIHESFRVVALAEPPRLGGGQPSWLTPELLSLFLYQELRPLRQSEE 608
            .|.:: ..:.|:|......|||.|||::||||||.:|.....||.||.|::|.:..::||.:|||
  Rat   551 CLKERLQLTDEQLQNRSIFPIHPSFRIIALAEPPVVGSTTQQWLGPEFLTMFFFHHMKPLVKSEE 615

  Fly   609 AELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPLLQGLAGTLSTRQLLKLARRLAAYPESELSDVH 673
            .:::.::........:::||.:...||.:|||..|.||.:|||||||:::|||:.||...|   |
  Rat   616 LQVIKEMVPNVPQEALEKLLSVTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPSENL---H 677

  Fly   674 EMLQNTFLARFMPALSRGALEQAIQQVGIK-----PREIKLKSKKNQIAVEDNSLRIGSTRWPLG 733
            :.:....|:||:|:|::.|||:.:....|:     ..|.:|::.|.::..  .||:||:...|:.
  Rat   678 DAITKACLSRFLPSLAQSALEKNLADAAIEINADSSLEPELENYKCEVVA--GSLKIGTVSAPVH 740

  Fly   734 NPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLVGNQGVGKNKLVDRLLELMQRPREY 798
            |..:..  |||..|||:..||:.::|.:|:|:::||||||||||||||||:|||.|.|:.|||||
  Rat   741 NAHEKM--KVPDVLFYDNVQHMVVMEDMLKDFVLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREY 803

  Fly   799 IQLHRDTTVHSLTLQATLKDGQVSYEDSALVQAVRTGHVLVVDEADKAPVNVTCILRTLVESGEM 863
            |||||||||.|||||.::|||.:.||||.||:||:.||:||||||||||.||||||:||||:|||
  Rat   804 IQLHRDTTVQSLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILKTLVENGEM 868

  Fly   864 VLADGRRIVPPGEG--GRVPNSIETHPDFRLIVLANRPGFPFLGNDFFAALGDVFSCHAISNPDP 926
            :||||||||.....  || .|:|..|||||::||||||||||||||||..|||:||||||.||.|
  Rat   869 ILADGRRIVADAASVDGR-ENAIVVHPDFRMVVLANRPGFPFLGNDFFGTLGDIFSCHAIDNPKP 932

  Fly   927 ESEIFLLQQYGPKVPIKTLRTLVNAFGELRTLADEGMLNYPYSTREVVSIVKHLERYPEENMSEV 991
            .||:.:|:||||.||:..|..||.||||||.|||:|::||||||||||:||||||::|.|.:|.|
  Rat   933 HSELEMLKQYGPNVPVPVLEKLVAAFGELRNLADQGIINYPYSTREVVNIVKHLEKFPTEGLSSV 997

  Fly   992 VGNVLDFDRYQPEALQQVTQVLAKHGI-------------------------------------- 1018
            |.||.|||.|..:..:.:...|.|:||                                      
  Rat   998 VRNVFDFDSYNNDMREILMNTLHKYGIPIGAKPTNVQLAKEFPLPEKTFMGYWIIGQTGNGMQKV 1062

  Fly  1019 ----------------------------------------------------------------- 1018
                                                                             
  Rat  1063 LCPAETHRIDIKGPVLVNIEKYPIEKHESRFLNFTEECTSWRFPVDEVNLISDIAVSHENGEHTL 1127

  Fly  1019 ----------------------------------------------------------------- 1018
                                                                             
  Rat  1128 YVATCNPISLYFMNMTGENGFFVDFFDIFPRMASGSWRPFVTVAPLGSPLRGQVVLHEEQSNVVL 1192

  Fly  1019 --------------------------------ESY------------------------------ 1021
                                            |:|                              
  Rat  1193 LLDTTGRAIHRLVLPTEESTSKKSSWWNKEEGETYRMCKEFSHKNWVVFYRQTGNSLTVLDVLEG 1257

  Fly  1022 -----------------------------------------------------AEEEI------- 1026
                                                                 .:||:       
  Rat  1258 LTHTISLPINLRTVFLVAEDKWLLVENKTNQKCLLTKPAHIGAEDTGACQLYMLKEELPSTGFGV 1322

  Fly  1027 ----------------------------------------------------------------- 1026
                                                                             
  Rat  1323 TQETEFYVPHKVSSDQLSSENLTSAVGQKIASPNRILSDEKSHATIVVGFPDLMSPCEVYSWKRS 1387

  Fly  1027 -----------------------------------QAIR-------------------------- 1030
                                               |.:|                          
  Rat  1388 SSLGKPSVTNITMYTGKRTSVTPRHNNCVTLTHTNQVVRILPAGEVPLKDIYPKDVTPPQTAGYI 1452

  Fly  1031 ----------------------------------------------------------------- 1030
                                                                             
  Rat  1453 EVTDLQAKKLRYIPVPSAESLSPYTAWLSAISDTDALLAEWDKSSVVTVDMGGCVRLWETGLERL 1517

  Fly  1031 --------------KQRILQASVNRHSGLGVSGPKFGKLDPKNEPHVGGNTWAGGSGGRDTAGLG 1081
                          ..:.:|.::.|.|...||.||.||.||.|.|||||||||||:|||||||||
  Rat  1518 QQSLMEWRNMIGQDSDKHMQITIERDSNEDVSEPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLG 1582

  Fly  1082 GKGGPFRLDKGHKVHQLSDEEKADVPEEIKRAAREMNRKAFEDKLKEIKMSAHDHKLYAQFSEPN 1146
            |||||:|||.||.|:|:|:.||..|||:||||||||.::||:.:||||:||.:|...|.:||...
  Rat  1583 GKGGPYRLDAGHPVYQVSEVEKDAVPEDIKRAAREMAQRAFQQRLKEIQMSEYDAATYERFSRAV 1647

  Fly  1147 RKQVQQLKAVLEAMQTKSKERQWQKYQTHGDLDDTRLVEGITGEKNIYRRRAEANPWADHVQEKP 1211
            ::||..|:.:|:.:|.|.|||||.::|..|:|||.::::|:.|||.||:||.:..|.....|:||
  Rat  1648 QRQVHALRVILDNLQAKGKERQWLRHQATGELDDAKIIDGLAGEKAIYKRRGDLEPQLGSPQQKP 1712

  Fly  1212 NRLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVMEAFEGFEKKIVYDIIGHSGEGWEIPFVTAGS 1276
            .||:||||||||||||||.|.||:|.:|||.|||||||.:|:|..|||.||||:|:.|..|....
  Rat  1713 KRLRLVVDVSGSMYRFNGVDRRLERSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIKLVPVNK 1777

  Fly  1277 PPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAEQDYDNAIVVVLSDANLQRYGIAP 1341
            .|||:|:|.|.::.||||||||.|||.|::....|...:..| :.|...|::||||||.||||.|
  Rat  1778 IPKNNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKDITTE-EADEYFVIILSDANLSRYGINP 1841

  Fly  1342 KDLAMALKRGEPKVKGYAIFIGSLAEEADEINAEMPAGQSFVCMDLTKLPHILQQIFTSSLL 1403
            ...|..| ...|:|..:|||||||.::|..:...:|||:||:.||..|:|.||||||||::|
  Rat  1842 ARFAQIL-TSNPQVNAFAIFIGSLGDQAARLQRTLPAGRSFIAMDTKKIPQILQQIFTSTML 1902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c12.2NP_001259381.1 AAA_5 112..268 CDD:285029 110/155 (71%)
AAA_5 435..595 CDD:285029 81/160 (51%)
AAA_5 770..916 CDD:285029 110/147 (75%)
vWA_F11C1-5a_type 1212..1403 CDD:238732 104/190 (55%)
Vwa8XP_038949970.1 AAA_5 104..260 CDD:400191 110/155 (71%)
MDN1 <163..>845 CDD:227596 316/689 (46%)
AAA_5 441..602 CDD:400191 81/160 (51%)
AAA_5 775..922 CDD:400191 110/147 (75%)
vWFA 1713..1902 CDD:412136 104/190 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166339582
Domainoid 1 1.000 225 1.000 Domainoid score I2457
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48751at33208
OrthoFinder 1 1.000 - - FOG0007423
OrthoInspector 1 1.000 - - oto97824
orthoMCL 1 0.900 - - OOG6_104715
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5558
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.750

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