DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c12.2 and MDN1

DIOPT Version :9

Sequence 1:	NP_001259381.1	Gene:	c12.2 / 53434	FlyBaseID:	FBgn0040234	Length:	1403	Species:	Drosophila melanogaster
Sequence 2:	NP_055426.1	Gene:	MDN1 / 23195	HGNCID:	18302	Length:	5596	Species:	Homo sapiens

Alignment Length:	1843	Identity:	352/1843 - (19%)
Similarity:	581/1843 - (31%)	Gaps:	698/1843 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AGKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYASDGTLQLS--Q 94
            ||:.:.:|:...|.:|   |.|....:|.||..           ..:.|.||.....:.|:|  :
Human  1307 AGRVRKQEEIDVIQEV---LEKHFKKKLCPQSL-----------FSKENVLKLLGKLSTQISTLE 1357

  Fly    95 SALHHLRW--------MLQKDALR--QDMFLLGQPGPLRRQLAMQFLELTQREVEYVALSRDTTE 149
            ....|:.|        ||...||.  :.:.|:|..|..:..:...|..|..:::..|:.......
Human  1358 CNFGHIVWTEGMRRLAMLVGRALEFGEPVLLVGDTGCGKTTICQVFAALANQKLYSVSCHLHMET 1422

  Fly   150 SDL-----KQRREINDRAAI-------FHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLEN 202
            ||.     ..|::.||:..|       :||...|:|.......:||.:..|:.:||..||::||
Human  1423 SDFLGGLRPVRQKPNDKEEIDTSRLFEWHDGPLVQAMKEDGFFLLDEISLADDSVLERLNSVLE- 1486

  Fly   203 REMHLESGKFLMSPERYDKLLEKHSREQLD-EWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRS 266
                         .|:...|.||.|.|..| |..||...::||::|...|...:....|.|.||:
Human  1487 -------------VEKSLVLAEKGSPEDKDSEIELLTAGKKFRILATMNPGGDFGKKELSPALRN 1538

  Fly   267 RFQSRNVTTYSYGELYEELQQEAP-SVPGEQLKQLLTF----ALTLQQADP--------VLQLPD 318
            ||.          |::      .| |...|.|.|:::.    .|.|.:.||        :|...|
Human  1539 RFT----------EIW------CPQSTSREDLIQIISHNLRPGLCLGRIDPKGSDIPEVMLDFID 1587

  Fly   319 FPIHNLALGVKMLAANPSLSLHDVISRIYPYQTMLKPDQKKRVEELLKKLDIQLVPSPSIKKIEA 383
            :..|. ..|.|.:     :|:.|::|.:                ..:.|:.    ...::|:.|.
Human  1588 WLTHQ-EFGRKCV-----VSIRDILSWV----------------NFMNKMG----EEAALKRPEI 1626

  Fly   384 QSQENSLIH----------------------------------------IKLDELQLN------- 401
            .|...|.:|                                        ::|.|.|.|
Human  1627 ISTVTSFVHAACLVYIDGIGSGVTSSGFGTALLARKECLKFLIKRLAKIVRLTEYQKNELKIYDR 1691

  Fly   402 -------------------LPEGQI----------PTASTYFVDLPHQRQALASLLQAYAVGDVC 437
                               :|.|.:          .:|.|..::.  ||...|:.|:.    .:.
Human  1692 MKAKEFTGIDNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNA--QRLLRATKLKK----PIL 1750

  Fly   438 LVGEKGVGKLTLTQELLRLLQQTSEPMMLYEDMTSRDIVQQRIT---SPQGDTVWRDSPLVRAAK 499
            |.|..||||.:|...|.:....|...:.|.|.....|:....:.   ...|:..|||.||:.|.|
Human  1751 LEGSPGVGKTSLVGALAKASGNTLVRINLSEQTDITDLFGADLPVEGGKGGEFAWRDGPLLAALK 1815

  Fly   500 SGSVAVLNGLHRLHKSTASVLQRL----IHDRELQLCDGTTLLGANRYQALLQQGFSKEELGKLG 560
            :|...||:   .|:.::.|||:.|    .|..|:.:                      .||| :.
Human  1816 AGHWVVLD---ELNLASQSVLEGLNACFDHRGEIYV----------------------PELG-MS 1854

  Fly   561 FLPIHESFRVVALAEPPRLGGGQPSWLTPELLSLFLYQELRPLRQSE------------EAELLA 613
            |...||..::.....|.|.|||:.. |....|:.|....:.||...:            |..::.
Human  1855 FQVQHEKTKIFGCQNPFRQGGGRKG-LPRSFLNRFTQVFVDPLTVIDMEFIASTLFPAIEKNIVK 1918

  Fly   614 QLC-------------------GGDLPAGMDQLLKLAQLLRSSQDPLLQGLAGTLSTRQLLKLAR 659
            ::.                   ||.....:..|.:..||:...|.|      |.....|.:.|..
Human  1919 KMVAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWCQLMLVDQSP------GCYDPGQHVFLVY 1977

  Fly   660 RLAAYPESELSDVHEMLQNTF-----------LARFMP--------ALSRGA------------L 693
            ......|.:...|..:.::.|           |.|..|        .||||:            |
Human  1978 GERMRTEEDKKKVIAVFKDVFGSNSNPYMGTRLFRITPYDVQLGYSVLSRGSCVPHPSRHPLLLL 2042

  Fly   694 EQAIQQ--------------VGIKPREI---------------KLKSKKNQIAVEDNSLRIGSTR 729
            .|:.|.              :.:.|..:               .||......|::...|..|..:
Human  2043 HQSFQPLESIMKCVQMSWMVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTELLGGFEQ 2107

  Fly   730 WPLGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLI------------GEHLLL------VGN 776
            ..|..|.:..|.||..|           :..||:|.|:            ..|.||      :|.
Human  2108 VDLIRPWRRLLEKVEGT-----------VRALLRDSLLISADDAEVVLRAWSHFLLTYKPKCLGE 2161

  Fly   777 QGVG-----KNKLVDRLLELMQR---------PREYIQL---HRDTTVHSLTLQATLKDGQVSYE 824
            .|..     .||| :.:|.||||         ..|:.:|   .|...|....|.:....|...:.
Human  2162 GGKAITMEIVNKL-EAVLLLMQRLNNKINSYCKAEFAKLVEEFRSFGVKLTQLASGHSHGTFEWV 2225

  Fly   825 DSALVQAVRTGHVLVVDEADKAPVNVTCILRTLVESGEMVLADGRRIVPPGEGGRVPNSIETHPD 889
            ||.||||:::|..|::|..:....:|...|..|:|.|.::....|.::    .|..| :|..:|:
Human  2226 DSMLVQALKSGDWLLMDNVNFCNPSVLDRLNALLEPGGVLTISERGMI----DGSTP-TITPNPN 2285

  Fly   890 FRLIVLANRPGFPFLGNDFFAALGDVFSCHAISNPDPESEIFLLQQYGPKVPIK-TLRTLVNAFG 953
            |||          ||..|  ...||:  ..|:.|..  .||::..:.....|.. .|:.|:::.|
Human  2286 FRL----------FLSMD--PVHGDI--SRAMRNRG--LEIYISGEGDASTPDNLDLKVLLHSLG 2334

  Fly   954 -----------ELRTLADEGMLNYPYST-----REVVSIVKHLERYPEENMSEVVGNVLDFDRYQ 1002
                       .|.|.....::..|.|:     :..:.||::|:|            .|..||..
Human  2335 LVGNSVCDILLALHTETRSTVVGSPTSSVSTLIQTAILIVQYLQR------------GLSLDRAF 2387

  Fly  1003 PEALQQVTQVLAKHG------IESYAEEEIQAIRKQRILQASVNRHSGLG-----VSGPKFGKLD 1056
            .||..:| .|.::|.      :::..|:.:.::|.......|:   .|:|     |....|...|
Human  2388 SEACWEV-YVCSQHSPANRKLVQALLEKHVSSLRAHETWGDSI---LGMGLWPDSVPSALFATED 2448

  Fly  1057 PK---------------NEPHVGGNTWAGGSGGRDTAGLGGKGGPFRLDKGHKVHQLSDEEKADV 1106
            ..               |...:..::|.             :..||.|....|:.|      :..
Human  2449 SHLSTVRRDGQILVYCLNRMSMKTSSWT-------------RSQPFTLQDLEKIMQ------SPS 2494

  Fly  1107 PEEIKRAAREMN-------------------RKAFEDKLKEIKMSAH------------------ 1134
            ||.:|..|.|:|                   |...:|.:..:|...|
Human  2495 PENLKFNAVEVNTYWIDEPDVLVMAVKLLIERATNQDWMLRVKWLYHLAKNIPQGLESIQIHLEA 2559

  Fly  1135 ---------DHKLYAQFS------------------------------------EPNRKQVQQLK 1154
                     .|.|....|                                    :|...|..||.
Human  2560 SAASLRNFYSHSLSGAVSNVFKILQPNTTDEFVIPLDPRWNMQALDMIRNLMDFDPQTDQPDQLF 2624

  Fly  1155 AVLEAMQTKS-----KERQ--------------------WQKYQTHGD----------------- 1177
            |:||:...|:     :|::                    ...::.|.|
Human  2625 ALLESAANKTIIYLDREKRVFTEANLVSVGSKKLRESVLRMSFEFHQDPESYHTLPHEIVVNLAA 2689

  Fly  1178 ---LDDTRLV------EGITGEKNIYRRRAEANP------WADHVQEKPNRLKLVVDVSG-SMYR 1226
               |.|..::      :|:..:       |.||.      |.|......:.:|  ||..| ::..
Human  2690 FFELCDALVLLWVQSSQGMVSD-------ASANEILGSLRWRDRFWTVADTVK--VDAPGLALLA 2745

  Fly  1227 FN-----------------GYDGRLDRQLEAVVMVME--------AFEGFEKKIVYDIIGHSGEG 1266
            .:                 .|:.:..::::.|...::        .|.|.:|  :...:|.
Human  2746 LHWHWVLKHLVHQIPRLLMNYEDKYYKEVQTVSEHIQNCLGSQTGGFAGIKK--LQKFLGR---- 2804

  Fly  1267 WEIPFVTAGSPPKNDK---ERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGA---EQDYDNAI 1325
               ||      |..||   |.|..::::           :.|.|.||..|.||.   ::|.:...
Human  2805 ---PF------PFKDKLVVECFSQLKVL-----------NKVLAIREQMSALGESGWQEDINRLQ 2849

  Fly  1326 VV----VLSDANLQRYGIAPK-----DLAM-ALKRG------EPKVKGYAIFIGSLAEEADEINA 1374
            ||    .|..:.||.:|:..:     |::: .||..      |.|.||  :.:|.|.::.||
Human  2850 VVASQWTLKKSLLQAWGLILRANILEDVSLDELKNFVHAQCLELKAKG--LSLGFLEKKHDE--- 2909

  Fly  1375 EMPAGQSFVCMDLTKLPHILQQI 1397
                ..|....|||.:.|:.:.:
Human  2910 ----ASSLSHPDLTSVIHLTRSV 2928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:285029	43/168 (26%)
		AAA_5	435..595	CDD:285029	43/166 (26%)
		AAA_5	770..916	CDD:285029	46/168 (27%)
		vWA_F11C1-5a_type	1212..1403	CDD:238732	47/234 (20%)
MDN1	NP_055426.1	AAA-ATPase protomer 1. /evidence=ECO:0000255	307..591
		P-loop_NTPase	325..453	CDD:304359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..537
		AAA-ATPase protomer 2. /evidence=ECO:0000255	659..978
		AAA	659..>780	CDD:99707
		P-loop_NTPase	672..902	CDD:304359
		AAA-ATPase protomer 3. /evidence=ECO:0000255	1048..1316		3/8 (38%)
		AAA	1079..1221	CDD:214640
		P-loop_NTPase	1079..1215	CDD:304359
		AAA-ATPase protomer 4. /evidence=ECO:0000255	1362..1616		70/305 (23%)
		AAA	1383..1540	CDD:214640	43/170 (25%)
		AAA_5	1385..1540	CDD:285029	43/168 (26%)
		MoxR	1736..>1923	CDD:223786	51/219 (23%)
		AAA-ATPase protomer 5. /evidence=ECO:0000255	1738..1995		62/293 (21%)
		P-loop_NTPase	1748..1888	CDD:304359	43/166 (26%)
		AAA-ATPase protomer 6. /evidence=ECO:0000255	2053..2313		66/292 (23%)
		P-loop_NTPase	<2220..2306	CDD:304359	29/104 (28%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q12019	2418..4691		93/577 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3989..4008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4669..4688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4700..5260
		Prothymosin	4912..5020	CDD:281265
		vWA_midasin	5323..5593	CDD:238737
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5271
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810