Protein Alignment c12.2 and VWA8

DIOPT Version :10

• Sequence 1: NP_001259381.1
• Gene: c12.2 / 53434
• FlyBaseID: FBgn0040234
• Length: 1403
• Species: Drosophila melanogaster
• Sequence 2: NP_055873.1
• Gene: VWA8 / 23078
• HGNCID: 29071
• Length: 1905
• Species: Homo sapiens
• Alignment Length: 1889
• Identity: 727/1889 - (38%)
• Similarity: 957/1889 - (50%)
• Gaps: 551/1889 - (29%)

  Fly    32 AGKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYASDGTLQLSQSA 96
            ||......|::.|||||.:|:.||:|:||||.|...|                       |:||.
Human    48 AGSGADTGDTVNIGDVSYKLKIPKNPELVPQNYISDS-----------------------LAQSV 89

  Fly    97 LHHLRWMLQKDALRQDMFLLGQPGPLRRQLAMQFLELTQREVEYVALSRDTTESDLKQRREINDR 161
            :.||||::|||.|.||:||:|.||||||.:|||:||||:|||||:||||||||:||||||||...
Human    90 VQHLRWIMQKDLLGQDVFLIGPPGPLRRSIAMQYLELTKREVEYIALSRDTTETDLKQRREIRAG 154

  Fly   162 AAIFHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMSPERYDKLLEKH 226
            .|.:.||.|||||..||.|:|:|:|.|||||||:||||||||||.||.|:||||.|||||||..|
Human   155 TAFYIDQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDH 219

  Fly   227 SREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGELYEELQQEAPS 291
            ::::||.|.::||||.|||:|||||..:|.|.|||||||||||:|::....:.:..:.|.....:
Human   220 TKKELDSWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGAN 284

  Fly   292 VPGEQLKQLLTFALTL-QQADPVLQLPDFPIHNLALGVKMLAANPSLSLHDVISRIYPYQTMLKP 355
            |..|::.|||:||.|| .|....|.|||||:.:||..|::|.:.|.:.:...|..:|||..:|..
Human   285 VSAEKVSQLLSFATTLCSQESSTLGLPDFPLDSLAAAVQILDSFPMMPIKHAIQWLYPYSILLGH 349

  Fly   356 DQKKRVEELLKKLDIQ-----LVPSPSIKKIEAQ-----SQENSLIHIKLDELQLNLPEG----Q 406
            :.|..||.:||:.::|     |:|. .|.|:|..     ||.:..|.|...|:.:.:|.|    .
Human   350 EGKMAVEGVLKRFELQDSGSSLLPK-EIVKVEKMMENHVSQASVTIRIADKEVTIKVPAGTRLLS 413

  Fly   407 IPTASTYFVDLPHQRQALASLLQAYAVGDVCLVGEKGVGKLTLTQELLRLLQQTSEPMMLYEDMT 471
            .|.||..|:.....:|..|.::|::.|.|:||:|.||.||..:.:.....|....||:|||:|||
Human   414 QPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMT 478

  Fly   472 SRDIVQQRITSPQGDTVWRDSPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIHDRELQLCDGTT 536
            :||::|||.|.|.|||.||.||||.||..|.:.:|:|:||::..|.:|||||||||||.|.||:.
Human   479 ARDLLQQRYTLPNGDTAWRSSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSR 543

  Fly   537 LLGANRYQALLQQ-GFSKEELGKLGFLPIHESFRVVALAEPPRLGGGQPSWLTPELLSLFLYQEL 600
            ||..:||..|.:: ..|.|:|.|....|||.|||::||||||.:|.....||.||.|::|.:..:
Human   544 LLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVIGSTAHQWLGPEFLTMFFFHYM 608

  Fly   601 RPLRQSEEAELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPLLQGLAGTLSTRQLLKLARRLAAYP 665
            :||.:|||.:::.:.........:|:||.....||.:|||..|.||.:|||||||:::|||:.||
Human   609 KPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYP 673

  Fly   666 ESELSDVHEMLQNTFLARFMPALSRGALEQAIQQVGIKPR-----EIKLKSKKNQIAVEDNSLRI 725
            ...|   |..:....|:||:|:|:|.|||:.:....|:..     |.:||..|.:  |...:|||
Human   674 NENL---HSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCE--VTSGTLRI 733

  Fly   726 GSTRWPLGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLVGNQGVGKNKLVDRLLE 790
            |:...|:.|..:..  |||..|||:..|||.::|.:|:|:|:||||||||||||||||:|||.|.
Human   734 GAVSAPIYNAHEKM--KVPDVLFYDNIQHVIVMEDMLKDFLLGEHLLLVGNQGVGKNKIVDRFLH 796

  Fly   791 LMQRPREYIQLHRDTTVHSLTLQATLKDGQVSYEDSALVQAVRTGHVLVVDEADKAPVNVTCILR 855
            |:.||||||||||||||.:||||.::|||.:.||||.||:||:.||:||||||||||.||||||:
Human   797 LLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILK 861

  Fly   856 TLVESGEMVLADGRRIV--PPGEGGRVPNSIETHPDFRLIVLANRPGFPFLGNDFFAALGDVFSC 918
            ||||:|||:||||||||  .....|| .|.:..|||||:|||||||||||||||||..|||:|||
Human   862 TLVENGEMILADGRRIVANSANVNGR-ENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSC 925

  Fly   919 HAISNPDPESEIFLLQQYGPKVPIKTLRTLVNAFGELRTLADEGMLNYPYSTREVVSIVKHLERY 983
            ||:.||.|.||:.:|:||||.||...|:.||.||||||:|||:|::||||||||||:|||||:::
Human   926 HAVDNPKPHSELEMLRQYGPNVPEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKF 990

  Fly   984 PEENMSEVVGNVLDFDRYQPEALQQVTQVLAKHGI------------------------------ 1018
            |.|.:|.||.||.|||.|..:..:.:...|.|:||
Human   991 PTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLAKELTLPEQTFMGYWTIGQ 1055

  Fly  1019 ----------------------------------------------------------------- 1018
                                                                             
Human  1056 ARSGMQKLLCPVETHHIDIKGPALINIQEYPIERHEERSLNFTEECASWRIPLDEINIICDIATS 1120

  Fly  1019 ----------------------------------------------------------------- 1018
                                                                             
Human  1121 HENEQNTLYVVTCNPASLYFMNMTGKSGFFVDFFDIFPRTANGVWHPFVTVAPLGSPLKGQVVLH 1185

  Fly  1019 ----------------------------------------ESY---------------------- 1021
                                                    |:|
Human  1186 EQQSNVILLLDTTGRALHRLILPSEKFTSKKPFWWNKEEAETYKMCKEFSHKNWLVFYKEKGNSL 1250

  Fly  1022 ----------------------------------------------------------------- 1021
                                                                             
Human  1251 TVLDVLEGRTHTISLPINLKTVFLVAEDKWLLVESKTNQKYLLTKPAHIESEGSGVCQLYVLKEE 1315

  Fly  1022 -------------------------AEEEIQAIRKQRI--------------------------- 1034
                                     :.|.:.:..:|:|
Human  1316 PPSTGFGVTQETEFSIPHKISSDQLSSEHLSSAVEQKIASPNRILSDEKNYATIVVGFPDLMSPS 1380

  Fly  1035 ----------------------------------------------------------------- 1034
                                                                             
Human  1381 EVYSWKRPSSLHKRSGTDTSFYRGKKKRGTPKQSNCVTLLDTNQVVRILPPGEVPLKDIYPKDVT 1445

  Fly  1035 ----------------------------------------------------------------- 1034
                                                                             
Human  1446 PPQTSGYIEVTDLQSKKLRYIPIPRSESLSPYTTWLSTISDTDALLAEWDKSGVVTVDMGGHIRL 1510

  Fly  1035 -------------------------LQASVNRHSGLGVSGPKFGKLDPKNEPHVGGNTWAGGSGG 1074
                                     :|.::||.||..||.||.||.||.|.|||||||||||:||
Human  1511 WETGLERLQRSLMEWRNMIGQDDRNMQITINRDSGEDVSSPKHGKEDPDNMPHVGGNTWAGGTGG 1575

  Fly  1075 RDTAGLGGKGGPFRLDKGHKVHQLSDEEKADVPEEIKRAAREMNRKAFEDKLKEIKMSAHDHKLY 1139
            ||||||||||||:|||.||.|:|:|..||..||||:|||||||.::||:.:||||:||.:|...|
Human  1576 RDTAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAATY 1640

  Fly  1140 AQFSEPNRKQVQQLKAVLEAMQTKSKERQWQKYQTHGDLDDTRLVEGITGEKNIYRRRAEANPWA 1204
            .:||...|:||..|:.:|:.:|.|.|||||.::|..|:|||.::::|:||||.||:||.|..|..
Human  1641 ERFSGAVRRQVHSLRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQL 1705

  Fly  1205 DHVQEKPNRLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVMEAFEGFEKKIVYDIIGHSGEGWEI 1269
            ...|:||.||:|||||||||||||..||||:|.:|||.|||||||.:|:|..|||:||||:|:.|
Human  1706 GSPQQKPKRLRLVVDVSGSMYRFNRMDGRLERTMEAVCMVMEAFENYEEKFQYDIVGHSGDGYNI 1770

  Fly  1270 PFVTAGSPPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAEQDYDNAIVVVLSDANL 1334
            ..|.....||::|:|.|.::.||||||||.|||.|::....|...: .:::.|...|:|||||||
Human  1771 GLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEI-VKEEADEYFVIVLSDANL 1834

  Fly  1335 QRYGIAPKDLAMALKRGEPKVKGYAIFIGSLAEEADEINAEMPAGQSFVCMDLTKLPHILQQIFT 1399
            .||||.|...|..|.| :|:|..:|||||||.::|..:...:|||:|||.||...:|.|||||||
Human  1835 SRYGIHPAKFAQILTR-DPQVNAFAIFIGSLGDQATRLQRTLPAGRSFVAMDTKDIPQILQQIFT 1898

  Fly  1400 SSLL 1403
            |::|
Human  1899 STML 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:400191	109/155 (70%)
		AAA_5	435..595	CDD:400191	82/160 (51%)
		AAA_5	770..916	CDD:400191	109/147 (74%)
		vWA_F11C1-5a_type	1212..1403	CDD:238732	104/190 (55%)
VWA8	NP_055873.1	Interaction with PEX7. /evidence=ECO:0000269|PubMed:30204880	1..261		139/235 (59%)
		AAA_5	105..261	CDD:400191	109/155 (70%)
		P-loop containing Nucleoside Triphosphate Hydrolases	442..603	CDD:476819	82/160 (51%)
		AAA_5	776..923	CDD:400191	109/147 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1542..1563		12/20 (60%)
		NorD	<1626..>1750	CDD:443612	69/123 (56%)
		vWA_F11C1-5a_type	1713..1902	CDD:238732	104/190 (55%)