DRSC/TRiP Functional Genomics Resources

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Protein Alignment c12.2 and VWA8

DIOPT Version :9

Sequence 1:NP_001259381.1 Gene:c12.2 / 53434 FlyBaseID:FBgn0040234 Length:1403 Species:Drosophila melanogaster
Sequence 2:NP_055873.1 Gene:VWA8 / 23078 HGNCID:29071 Length:1905 Species:Homo sapiens


Alignment Length:1889 Identity:727/1889 - (38%)
Similarity:957/1889 - (50%) Gaps:551/1889 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 AGKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYASDGTLQLSQSA 96
            ||......|::.|||||.:|:.||:|:||||.|...|                       |:||.
Human    48 AGSGADTGDTVNIGDVSYKLKIPKNPELVPQNYISDS-----------------------LAQSV 89

  Fly    97 LHHLRWMLQKDALRQDMFLLGQPGPLRRQLAMQFLELTQREVEYVALSRDTTESDLKQRREINDR 161
            :.||||::|||.|.||:||:|.||||||.:|||:||||:|||||:||||||||:||||||||...
Human    90 VQHLRWIMQKDLLGQDVFLIGPPGPLRRSIAMQYLELTKREVEYIALSRDTTETDLKQRREIRAG 154

  Fly   162 AAIFHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMSPERYDKLLEKH 226
            .|.:.||.|||||..||.|:|:|:|.|||||||:||||||||||.||.|:||||.|||||||..|
Human   155 TAFYIDQCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDH 219

  Fly   227 SREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGELYEELQQEAPS 291
            ::::||.|.::||||.|||:|||||..:|.|.|||||||||||:|::....:.:..:.|.....:
Human   220 TKKELDSWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLKLLYSIGAN 284

  Fly   292 VPGEQLKQLLTFALTL-QQADPVLQLPDFPIHNLALGVKMLAANPSLSLHDVISRIYPYQTMLKP 355
            |..|::.|||:||.|| .|....|.|||||:.:||..|::|.:.|.:.:...|..:|||..:|..
Human   285 VSAEKVSQLLSFATTLCSQESSTLGLPDFPLDSLAAAVQILDSFPMMPIKHAIQWLYPYSILLGH 349

  Fly   356 DQKKRVEELLKKLDIQ-----LVPSPSIKKIEAQ-----SQENSLIHIKLDELQLNLPEG----Q 406
            :.|..||.:||:.::|     |:|. .|.|:|..     ||.:..|.|...|:.:.:|.|    .
Human   350 EGKMAVEGVLKRFELQDSGSSLLPK-EIVKVEKMMENHVSQASVTIRIADKEVTIKVPAGTRLLS 413

  Fly   407 IPTASTYFVDLPHQRQALASLLQAYAVGDVCLVGEKGVGKLTLTQELLRLLQQTSEPMMLYEDMT 471
            .|.||..|:.....:|..|.::|::.|.|:||:|.||.||..:.:.....|....||:|||:|||
Human   414 QPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKGCGKTVIAKNFADTLGYNIEPIMLYQDMT 478

  Fly   472 SRDIVQQRITSPQGDTVWRDSPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIHDRELQLCDGTT 536
            :||::|||.|.|.|||.||.||||.||..|.:.:|:|:||::..|.:|||||||||||.|.||:.
Human   479 ARDLLQQRYTLPNGDTAWRSSPLVNAALEGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSR 543

  Fly   537 LLGANRYQALLQQ-GFSKEELGKLGFLPIHESFRVVALAEPPRLGGGQPSWLTPELLSLFLYQEL 600
            ||..:||..|.:: ..|.|:|.|....|||.|||::||||||.:|.....||.||.|::|.:..:
Human   544 LLREDRYMRLKEELQLSDEQLQKRSIFPIHPSFRIIALAEPPVIGSTAHQWLGPEFLTMFFFHYM 608

  Fly   601 RPLRQSEEAELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPLLQGLAGTLSTRQLLKLARRLAAYP 665
            :||.:|||.:::.:.........:|:||.....||.:|||..|.||.:|||||||:::|||:.||
Human   609 KPLVKSEEIQVIKEKVPNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYP 673

  Fly   666 ESELSDVHEMLQNTFLARFMPALSRGALEQAIQQVGIKPR-----EIKLKSKKNQIAVEDNSLRI 725
            ...|   |..:....|:||:|:|:|.|||:.:....|:..     |.:||..|.:  |...:|||
Human   674 NENL---HSAVTKACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCE--VTSGTLRI 733

  Fly   726 GSTRWPLGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLVGNQGVGKNKLVDRLLE 790
            |:...|:.|..:..  |||..|||:..|||.::|.:|:|:|:||||||||||||||||:|||.|.
Human   734 GAVSAPIYNAHEKM--KVPDVLFYDNIQHVIVMEDMLKDFLLGEHLLLVGNQGVGKNKIVDRFLH 796

  Fly   791 LMQRPREYIQLHRDTTVHSLTLQATLKDGQVSYEDSALVQAVRTGHVLVVDEADKAPVNVTCILR 855
            |:.||||||||||||||.:||||.::|||.:.||||.||:||:.||:||||||||||.||||||:
Human   797 LLNRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILK 861

  Fly   856 TLVESGEMVLADGRRIV--PPGEGGRVPNSIETHPDFRLIVLANRPGFPFLGNDFFAALGDVFSC 918
            ||||:|||:||||||||  .....|| .|.:..|||||:|||||||||||||||||..|||:|||
Human   862 TLVENGEMILADGRRIVANSANVNGR-ENVVVIHPDFRMIVLANRPGFPFLGNDFFGTLGDIFSC 925

  Fly   919 HAISNPDPESEIFLLQQYGPKVPIKTLRTLVNAFGELRTLADEGMLNYPYSTREVVSIVKHLERY 983
            ||:.||.|.||:.:|:||||.||...|:.||.||||||:|||:|::||||||||||:|||||:::
Human   926 HAVDNPKPHSELEMLRQYGPNVPEPILQKLVAAFGELRSLADQGIINYPYSTREVVNIVKHLQKF 990

  Fly   984 PEENMSEVVGNVLDFDRYQPEALQQVTQVLAKHGI------------------------------ 1018
            |.|.:|.||.||.|||.|..:..:.:...|.|:||                              
Human   991 PTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAKPTSVQLAKELTLPEQTFMGYWTIGQ 1055

  Fly  1019 ----------------------------------------------------------------- 1018
                                                                             
Human  1056 ARSGMQKLLCPVETHHIDIKGPALINIQEYPIERHEERSLNFTEECASWRIPLDEINIICDIATS 1120

  Fly  1019 ----------------------------------------------------------------- 1018
                                                                             
Human  1121 HENEQNTLYVVTCNPASLYFMNMTGKSGFFVDFFDIFPRTANGVWHPFVTVAPLGSPLKGQVVLH 1185

  Fly  1019 ----------------------------------------ESY---------------------- 1021
                                                    |:|                      
Human  1186 EQQSNVILLLDTTGRALHRLILPSEKFTSKKPFWWNKEEAETYKMCKEFSHKNWLVFYKEKGNSL 1250

  Fly  1022 ----------------------------------------------------------------- 1021
                                                                             
Human  1251 TVLDVLEGRTHTISLPINLKTVFLVAEDKWLLVESKTNQKYLLTKPAHIESEGSGVCQLYVLKEE 1315

  Fly  1022 -------------------------AEEEIQAIRKQRI--------------------------- 1034
                                     :.|.:.:..:|:|                           
Human  1316 PPSTGFGVTQETEFSIPHKISSDQLSSEHLSSAVEQKIASPNRILSDEKNYATIVVGFPDLMSPS 1380

  Fly  1035 ----------------------------------------------------------------- 1034
                                                                             
Human  1381 EVYSWKRPSSLHKRSGTDTSFYRGKKKRGTPKQSNCVTLLDTNQVVRILPPGEVPLKDIYPKDVT 1445

  Fly  1035 ----------------------------------------------------------------- 1034
                                                                             
Human  1446 PPQTSGYIEVTDLQSKKLRYIPIPRSESLSPYTTWLSTISDTDALLAEWDKSGVVTVDMGGHIRL 1510

  Fly  1035 -------------------------LQASVNRHSGLGVSGPKFGKLDPKNEPHVGGNTWAGGSGG 1074
                                     :|.::||.||..||.||.||.||.|.|||||||||||:||
Human  1511 WETGLERLQRSLMEWRNMIGQDDRNMQITINRDSGEDVSSPKHGKEDPDNMPHVGGNTWAGGTGG 1575

  Fly  1075 RDTAGLGGKGGPFRLDKGHKVHQLSDEEKADVPEEIKRAAREMNRKAFEDKLKEIKMSAHDHKLY 1139
            ||||||||||||:|||.||.|:|:|..||..||||:|||||||.::||:.:||||:||.:|...|
Human  1576 RDTAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEEVKRAAREMGQRAFQQRLKEIQMSEYDAATY 1640

  Fly  1140 AQFSEPNRKQVQQLKAVLEAMQTKSKERQWQKYQTHGDLDDTRLVEGITGEKNIYRRRAEANPWA 1204
            .:||...|:||..|:.:|:.:|.|.|||||.::|..|:|||.::::|:||||.||:||.|..|..
Human  1641 ERFSGAVRRQVHSLRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQL 1705

  Fly  1205 DHVQEKPNRLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVMEAFEGFEKKIVYDIIGHSGEGWEI 1269
            ...|:||.||:|||||||||||||..||||:|.:|||.|||||||.:|:|..|||:||||:|:.|
Human  1706 GSPQQKPKRLRLVVDVSGSMYRFNRMDGRLERTMEAVCMVMEAFENYEEKFQYDIVGHSGDGYNI 1770

  Fly  1270 PFVTAGSPPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAEQDYDNAIVVVLSDANL 1334
            ..|.....||::|:|.|.::.||||||||.|||.|::....|...: .:::.|...|:|||||||
Human  1771 GLVPMNKIPKDNKQRLEILKTMHAHSQFCMSGDHTLEGTEHAIKEI-VKEEADEYFVIVLSDANL 1834

  Fly  1335 QRYGIAPKDLAMALKRGEPKVKGYAIFIGSLAEEADEINAEMPAGQSFVCMDLTKLPHILQQIFT 1399
            .||||.|...|..|.| :|:|..:|||||||.::|..:...:|||:|||.||...:|.|||||||
Human  1835 SRYGIHPAKFAQILTR-DPQVNAFAIFIGSLGDQATRLQRTLPAGRSFVAMDTKDIPQILQQIFT 1898

  Fly  1400 SSLL 1403
            |::|
Human  1899 STML 1902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c12.2NP_001259381.1 AAA_5 112..268 CDD:285029 109/155 (70%)
AAA_5 435..595 CDD:285029 82/160 (51%)
AAA_5 770..916 CDD:285029 109/147 (74%)
vWA_F11C1-5a_type 1212..1403 CDD:238732 104/190 (55%)
VWA8NP_055873.1 Interaction with PEX7. /evidence=ECO:0000269|PubMed:30204880 1..261 139/235 (59%)
AAA_5 105..261 CDD:285029 109/155 (70%)
P-loop_NTPase 442..585 CDD:304359 74/142 (52%)
AAA_5 776..923 CDD:285029 109/147 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1542..1563 12/20 (60%)
vWA_F11C1-5a_type 1713..1902 CDD:238732 104/190 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145866
Domainoid 1 1.000 553 1.000 Domainoid score I245
eggNOG 1 0.900 - - E1_COG5271
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H44881
Inparanoid 1 1.050 1381 1.000 Inparanoid score I124
Isobase 1 0.950 - 0 Normalized mean entropy S5604
OMA 1 1.010 - - QHG56748
OrthoDB 1 1.010 - - D48751at33208
OrthoFinder 1 1.000 - - FOG0007423
OrthoInspector 1 1.000 - - oto90719
orthoMCL 1 0.900 - - OOG6_104715
Panther 1 1.100 - - LDO PTHR21610
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5558
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.720

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