DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment c12.2 and SMTNL1

DIOPT Version :9

Sequence 1:	NP_001259381.1	Gene:	c12.2 / 53434	FlyBaseID:	FBgn0040234	Length:	1403	Species:	Drosophila melanogaster
Sequence 2:	NP_001099035.2	Gene:	SMTNL1 / 219537	HGNCID:	32394	Length:	494	Species:	Homo sapiens

Alignment Length:	177	Identity:	40/177 - (22%)
Similarity:	60/177 - (33%)	Gaps:	49/177 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   981 ERYPEENMSEVVGNVLDFDRYQPEALQQVTQVLAKHGIE------------------SYAEEEIQ 1027
            |....|:...||.:....:..:|:..::     ||||.:                  |.:||:.|
Human   196 EEAKAESQKAVVEDEAKAEPKEPDGKEE-----AKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQ 255

  Fly  1028 AIRKQRILQASVNRHSGLGV--SGPKFGKLDPKNEPH------VGGNTWAGGSGGRDTAGLGGKG 1084
            .:.|:        ...|.||  |.|:.....|..|.|      :|.:..|.|    .|:....:.
Human   256 DVEKE--------PEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASG----QTSPSASES 308

  Fly  1085 GPFRLDKGHKVHQLSDEEKADVPEE------IKRAAREMNRKAFEDK 1125
            .|..:.:.......|.|:|...||.      ..|..|..||||..||
Human   309 SPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:285029
		AAA_5	435..595	CDD:285029
		AAA_5	770..916	CDD:285029
		vWA_F11C1-5a_type	1212..1403	CDD:238732
SMTNL1	NP_001099035.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..348		34/168 (20%)
		2A1904	<19..278	CDD:273344	19/94 (20%)
		CH	380..481	CDD:366016
		Calmodulin-binding. /evidence=ECO:0000250	476..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5271
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900