Protein Alignment c12.2 and Vwa8

DIOPT Version :9

• Sequence 1: NP_001259381.1
• Gene: c12.2 / 53434
• FlyBaseID: FBgn0040234
• Length: 1403
• Species: Drosophila melanogaster
• Sequence 2: NP_082182.1
• Gene: Vwa8 / 219189
• MGIID: 1919008
• Length: 1905
• Species: Mus musculus
• Alignment Length: 1881
• Identity: 711/1881 - (37%)
• Similarity: 954/1881 - (50%)
• Gaps: 550/1881 - (29%)

  Fly    40 DSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNELKYASDGTLQLSQSALHHLRWML 104
            ::::|||||.:|:.||:|:||||.|...|.                       :||.:.||||::
Mouse    55 ETVSIGDVSYKLKTPKNPELVPQNYISDSP-----------------------AQSIVQHLRWLM 96

  Fly   105 QKDALRQDMFLLGQPGPLRRQLAMQFLELTQREVEYVALSRDTTESDLKQRREINDRAAIFHDQG 169
            |||.|.||:||:|.||||||.:|||:||||:|||||:||||||||:||||||||....|.:.||.
Mouse    97 QKDLLGQDVFLIGPPGPLRRSVAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYIDQC 161

  Fly   170 AVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMSPERYDKLLEKHSREQLDEW 234
            |||||..||.|||:|:|.|||||||:||||||||||.||.|:||||.|||||||:.|::|:||.|
Mouse   162 AVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLQDHTKEELDAW 226

  Fly   235 GLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGELYEELQQEAPSVPGEQLKQ 299
            .::||||.|||:|||||..:|.|.|||||||||||:|::....:.:..:.|.....:|..|::.|
Mouse   227 KIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYFLPFQDQLKLLYSVGANVSAEKISQ 291

  Fly   300 LLTFALTL-QQADPVLQLPDFPIHNLALGVKMLAANPSLSLHDVISRIYPYQTMLKPDQKKRVEE 363
            ||:||.|| .|....|.|||||:.:|...|::|.:.|.:|:...:..:|||..:|..:.|..||.
Mouse   292 LLSFATTLCSQESSTLGLPDFPLDSLPEAVQILDSFPMMSIEHALQWVYPYTLLLGHEGKMAVEG 356

  Fly   364 LLKKLDIQ-----LVPSPSIKKIEAQSQENSLIHIKL----DELQLNLPEG----QIPTASTYFV 415
            :||:.::|     |:|...::.........|..|:.:    .|:.:.:|.|    ..|.|..:|:
Mouse   357 VLKRFELQGSGHSLLPKEIVRVERMTDSHGSYAHVTIRVAGKEVTIKVPAGTRAVNQPCAPDHFI 421

  Fly   416 DLPHQRQALASLLQAYAVGDVCLVGEKGVGKLTLTQELLRLLQQTSEPMMLYEDMTSRDIVQQRI 480
            .....:|.||.::|::.|.|:||:|.||.||..:.:....||..:.||:|||:|||:||::|||.
Mouse   422 QTVSHKQLLAEMVQSHMVKDICLIGGKGCGKTVIAKNFAALLGYSIEPIMLYQDMTARDLLQQRY 486

  Fly   481 TSPQGDTVWRDSPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIHDRELQLCDGTTLLGANRYQA 545
            |.|.|||.||.||||.||:.|.:.:|:|:||::..|.:|||||||||||.|.||:.||..:||.:
Mouse   487 TLPNGDTAWRSSPLVSAAREGKLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYLS 551

  Fly   546 LLQQ-GFSKEELGKLGFLPIHESFRVVALAEPPRLGGGQPSWLTPELLSLFLYQELRPLRQSEEA 609
            |.:: ..:.|:|......|||.|||::||||||.:|.....||.||.|::|.:..::||.:|||.
Mouse   552 LKEKLQLTDEQLQNRSIFPIHPSFRIIALAEPPIVGSTTQQWLGPEFLTMFFFHHMKPLVKSEEI 616

  Fly   610 ELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPLLQGLAGTLSTRQLLKLARRLAAYPESELSDVHE 674
            :::.:.........:::||.:...||.:|||..|.||.:|||||||:::|||:.||...|   |:
Mouse   617 QVIKETVPNVPQEALEKLLSVTHKLRETQDPTAQSLAASLSTRQLLRISRRLSKYPSENL---HD 678

  Fly   675 MLQNTFLARFMPALSRGALEQAIQQVGIKPR-----EIKLKSKKNQIAVEDNSLRIGSTRWPLGN 734
            .:....|:||:|:|::.|||:.:....|:..     |.:|::.|.::..  .||:||:...|:.|
Mouse   679 AITKACLSRFLPSLAQSALEKNLADAAIETNTEDSLEPELENYKCEVVA--GSLKIGAVSVPVHN 741

  Fly   735 PTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLVGNQGVGKNKLVDRLLELMQRPREYI 799
            ..:..  |||..|||:..||:.::|.:|:|:::||||||||||||||||:|||.|.|:.||||||
Mouse   742 AHEKM--KVPDVLFYDNVQHMVVMEDMLKDFVLGEHLLLVGNQGVGKNKIVDRFLHLLNRPREYI 804

  Fly   800 QLHRDTTVHSLTLQATLKDGQVSYEDSALVQAVRTGHVLVVDEADKAPVNVTCILRTLVESGEMV 864
            ||||||||.|||||.|:|.|.:.||||.||:||:.||:||||||||||.||||||:||||:|||:
Mouse   805 QLHRDTTVQSLTLQPTVKGGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVTCILKTLVENGEMI 869

  Fly   865 LADGRRIVPPGEG--GRVPNSIETHPDFRLIVLANRPGFPFLGNDFFAALGDVFSCHAISNPDPE 927
            ||||||||.....  || .|.:..|||||::.|||||||||||||||..|||:||||||.||.|.
Mouse   870 LADGRRIVADAANVDGR-ENLVAIHPDFRMLALANRPGFPFLGNDFFGTLGDIFSCHAIDNPKPH 933

  Fly   928 SEIFLLQQYGPKVPIKTLRTLVNAFGELRTLADEGMLNYPYSTREVVSIVKHLERYPEENMSEVV 992
            ||:.:|:||||.||...|:.||.||||||.|||:|::||||||||||:|||||:::|.|.:|.||
Mouse   934 SELSMLKQYGPDVPEPVLQKLVAAFGELRNLADQGIINYPYSTREVVNIVKHLQKFPTEGLSSVV 998

  Fly   993 GNVLDFDRYQPEALQQVTQVLAKHGIE-------------------------------------- 1019
            .||.|||.|..:..:.:...|.|:||.
Mouse   999 RNVFDFDSYNNDMREILMNTLHKYGIPIGAKPTNVQLAKEFPLPEKTFMGYWIVGQTGNGMQKVL 1063

  Fly  1020 -------------------------------SYAEE---------EI------------------ 1026
                                           |:.||         |:
Mouse  1064 CPAETNHVDIKGPVLVNMEKYPIEKHEARFLSFTEECTSWKFPLDEVNLICDIAVSHENGEQTLY 1128

  Fly  1027 ----------------------------------------------------------------- 1026
                                                                             
Mouse  1129 VAACNPVSLYFMNMTGKNGFFVDFFDIFPRMASGSWRPFVTVAPLGSPLRGQVVLHEEQSNAVLL 1193

  Fly  1027 -----QAIRK------------------------------------------------------- 1031
                 .|||:
Mouse  1194 LDTTGSAIRRLVLPTEEFTSKKSSWWSKEEGETYRMCKEFSHKNWVVFYKQTGNSLTVLDVLEGL 1258

  Fly  1032 ----------------------------------------------------------------- 1031
                                                                             
Mouse  1259 AHTISLPINLRTVFLVAEDKWLLVENETNQKYLLTKPAHIGSEDTGACQLYMLKEELPSTGFGVT 1323

  Fly  1032 --------------------------------QRIL----------------------------- 1035
                                            .|||
Mouse  1324 QETEFCIPDKVSSDQLSSENLTSAVGQKIASPNRILSDENSHATIVVGFPDLMSPSEVYSWKRSS 1388

  Fly  1036 ----------------------------------------------------------------- 1035
                                                                             
Mouse  1389 SLRQPSVTSMTMYTGKRTNATPRHNNCVTLTHTNQVVRILPPGEVPLKDLYPKDVTPPQTAGYIE 1453

  Fly  1036 ----------------------------------------------------------------- 1035
                                                                             
Mouse  1454 VTDLQAKKLRYIPVPSAESLSPYTAWISAISDTDALLAEWDKSSVVTVDMGGRVRLWETGLERLQ 1518

  Fly  1036 ------------------QASVNRHSGLGVSGPKFGKLDPKNEPHVGGNTWAGGSGGRDTAGLGG 1082
                              |.::.|.|...||.||.||.||.|.|||||||||||:||||||||||
Mouse  1519 QSLMEWRNMIGQDSDKHVQITIERDSNEDVSDPKHGKEDPDNMPHVGGNTWAGGTGGRDTAGLGG 1583

  Fly  1083 KGGPFRLDKGHKVHQLSDEEKADVPEEIKRAAREMNRKAFEDKLKEIKMSAHDHKLYAQFSEPNR 1147
            ||||:|||.||.|:|:|:.||..|||::|||||||.:|||:.:||||:||.:|...|.:||...:
Mouse  1584 KGGPYRLDAGHPVYQVSEVEKDAVPEDVKRAAREMAQKAFQQRLKEIQMSEYDAATYERFSSAVQ 1648

  Fly  1148 KQVQQLKAVLEAMQTKSKERQWQKYQTHGDLDDTRLVEGITGEKNIYRRRAEANPWADHVQEKPN 1212
            :||..|:.:|:.:|.|.|||||.::|..|:|||.::::|:.|||:||:||.:..|.....|:||.
Mouse  1649 RQVHALRIILDNLQAKGKERQWLRHQATGELDDAKIIDGLAGEKSIYKRRGDLEPQLGSPQQKPK 1713

  Fly  1213 RLKLVVDVSGSMYRFNGYDGRLDRQLEAVVMVMEAFEGFEKKIVYDIIGHSGEGWEIPFVTAGSP 1277
            ||:||||||||||||||.|.||:|.:|||.|||||||.:|:|..|||.||||:|:.|..|.....
Mouse  1714 RLRLVVDVSGSMYRFNGVDRRLERSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIKLVPVNQI 1778

  Fly  1278 PKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAEQDYDNAIVVVLSDANLQRYGIAPK 1342
            |||:|:|.|.::.||.|||||.|||.|::....|...:..| :.|...|::||||||.||||.|.
Mouse  1779 PKNNKQRLEILKTMHEHSQFCMSGDHTLEGTEHAIKDITTE-EADEYFVIILSDANLSRYGINPA 1842

  Fly  1343 DLAMALKRGEPKVKGYAIFIGSLAEEADEINAEMPAGQSFVCMDLTKLPHILQQIFTSSLL 1403
            ..|..| ..:|:|..:|||||||.::|..:...:|||:||:.||..|:|.||||||||::|
Mouse  1843 RFAQIL-TSDPQVNAFAIFIGSLGDQAARLQRTLPAGRSFIAMDTKKIPQILQQIFTSTML 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:285029	111/155 (72%)
		AAA_5	435..595	CDD:285029	81/160 (51%)
		AAA_5	770..916	CDD:285029	108/147 (73%)
		vWA_F11C1-5a_type	1212..1403	CDD:238732	103/190 (54%)
Vwa8	NP_082182.1	Interaction with PEX7. /evidence=ECO:0000250|UniProtKB:A3KMH1	1..260		137/227 (60%)
		AAA_5	104..260	CDD:285029	111/155 (72%)
		AAA_5	441..584	CDD:285029	73/142 (51%)
		AAA_5	775..922	CDD:285029	108/147 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1541..1583		30/41 (73%)
		vWFA	1713..1902	CDD:294047	103/190 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835944
Domainoid	1	1.000	544	1.000	Domainoid score	I261
eggNOG	1	0.900	-	-		E1_COG5271
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44881
Inparanoid	1	1.050	1366	1.000	Inparanoid score	I129
Isobase	1	0.950	-	0	Normalized mean entropy	S5604
OMA	1	1.010	-	-		QHG56748
OrthoDB	1	1.010	-	-		D48751at33208
OrthoFinder	1	1.000	-	-		FOG0007423
OrthoInspector	1	1.000	-	-		oto94306
orthoMCL	1	0.900	-	-		OOG6_104715
Panther	1	1.100	-	-	LDO	PTHR21610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3032
SonicParanoid	1	1.000	-	-		X5558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750