Protein Alignment c12.2 and F55F10.1

DIOPT Version :9

• Sequence 1: NP_001259381.1
• Gene: c12.2 / 53434
• FlyBaseID: FBgn0040234
• Length: 1403
• Species: Drosophila melanogaster
• Sequence 2: NP_001368166.1
• Gene: F55F10.1 / 186322
• WormBaseID: WBGene00018898
• Length: 4362
• Species: Caenorhabditis elegans
• Alignment Length: 1467
• Identity: 291/1467 - (19%)
• Similarity: 488/1467 - (33%)
• Gaps: 470/1467 - (32%)

  Fly   164 IFHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLL-ENREMHLESGKFLMSPERYDKLLEKHS 227
            :|.:...|:|..:|..::||.:..|..:|:..||.|| :|||        |..|| .::.::.|.
 Worm   800 VFREGALVQAVRDGSWVILDELNLAPTDVIEALNRLLDDNRE--------LFVPE-INETIKAHP 855

  Fly   228 REQLDEWGLLRVSEQFRVVALGLPTHKYKGTP-LDPPLRSRFQSRNVTTYSYGELYEELQQEAPS 291
            |              ||:.|...|...|.|.. |...|.|||...........||.|.:......
 Worm   856 R--------------FRLFATQNPAGSYAGRKRLSRALMSRFIVLRFHHLPIEELSEMVCARCGV 906

  Fly   292 VPGEQLKQ----------------------LLTF---------ALTLQQADPVLQLPDFPIHNLA 325
            .|...||.                      |:|.         ..|.:..|..||:  ...|
 Worm   907 PPNASLKMIEVLNELRNRRSLSGLFSARDGLMTLRDVFRWAKRMTTDETTDDWLQI--LVNH--- 966

  Fly   326 LGVKMLAANPSLSLHDVISRIYPYQTMLKPDQKKRVEELLKKLDIQLVPSPSIKKIEAQSQENSL 390
             |..:||........||.    ..:|:.|..::|..:|.|..||...:|...|
 Worm   967 -GYFLLAGRCRNEKDDVT----VVETLEKVIKRKIDKEALFSLDSPYMPRDVI------------ 1014

  Fly   391 IHIKLDELQLNLPEGQIPTASTYFVDLPHQRQALASLLQAYAVGD-VCLVGEKGVGKLTLTQEL- 453
                .:::.|.|                ..|:.|....||:...: |.:|||.|.||.||::.:
 Worm  1015 ----TEKVVLTL----------------GMRRMLVLTEQAWLRNEAVLMVGETGGGKTTLSEVVG 1059

  Fly   454 ---LRLLQQTSEPMMLYEDMTSRDIVQQRITSPQGDTVWRDSPLVRAAKSGSVAVLNGLHRLHKS 515
               ||.:.       .:|...:.|::.:......|...|.|..::.|.:.| |.:|  :..:..:
 Worm  1060 RGKLRSIN-------CHERTETADLLGRLRPKQDGGFEWSDGVVISAMRDG-VPLL--VDEISLA 1114

  Fly   516 TASVLQRL----IHDRELQLCDGTT----LLGANRYQ--ALLQQG--FSKEELGKLGFLPIHESF 568
            ..|||:||    ..||.|.|.|..|    :.....:|  |.:..|  :.|:||.|    .:...|
 Worm  1115 EDSVLERLNPLFEEDRALLLSDAGTDTEVVESKPGFQMIATMNPGGDYGKKELSK----ALRNRF 1175

  Fly   569 RVVALAEPPRLGGGQPSWLTPELLSLFLYQELRPLRQSEEAEL------------LAQLCG---- 617
            ..|..:.         .:.|.||:::|..:..|.....|||.:            :|...|
 Worm  1176 TEVWTSS---------DYTTSELVTIFDQRLARVDATREEARITPTRTATTIVSWIAVFFGKYSH 1231

  Fly   618 --GDLPAGMDQLLKLAQLLRSS-----------QDPL----LQGLAGTLSTRQLLKLARRLAAYP 665
              ...|:..| ::..|:|..|:           :|.|    |..|||         |..||...|
 Worm  1232 VFRHAPSVRD-VVACAELYASAMQAQIENTTAIKDALCAVFLDSLAG---------LTTRLHIDP 1286

  Fly   666 ----ESELSDVHEMLQNTFLARFMPALSRGALEQAIQQVGIKPREIKLKSKKNQIAVEDNS--LR 724
                :..|:.:|..|..|.|.        |.|....:.:|        ::||:.: :|..|  |.
 Worm  1287 VEVFDDALTMLHSELVKTQLL--------GQLSDVQKFIG--------EAKKDAL-IEHASQHLN 1334

  Fly   725 IGSTRWPLGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLVGNQGVGKNKLVDRLL 789
            :|..|.|.|..|    .|:|.....:.|...:...|:.:..||.:.:||.|..|.||:..|..|.
 Worm  1335 VGHLRVPFGPVT----PKIPKAFSLKAPTCAENFYRIARGLLISKPILLEGAPGCGKSSTVMALA 1395

  Fly   790 ELMQRPREYIQLHRDTTVHSL---TLQATLKDGQVSY--EDSALVQAVRTGHVLVVDEADKAPVN 849
            :|...|...:.|...|.:..|   .:....:||.:::  ||..:::|::.|..:::||.:.|..:
 Worm  1396 QLTGNPITRLNLSDQTDLSDLFGSDVPVLTEDGTMTFRWEDGPVLKAIKKGEWILLDEMNLASQS 1460

  Fly   850 VTCILRTLVESGEMVLADGRRIVPPGEGGRVPNSIETHPDFRL---------------IVLANRP 899
            |.        .|.....|.||::...|..|         :|.:               :...||.
 Worm  1461 VL--------EGLNACFDHRRVLYIAELNR---------EFEIPATSNCRFFACQNPRVQGGNRR 1508

  Fly   900 GFPFLGNDFFAALGDVFS-------CHAISNPDPESEIFLLQQYGPKVPIK-------------- 943
            ..|   ..|.....::::       ...:.|...|..:...:|....|.|.
 Worm  1509 ALP---KSFINRFTNIYTNDLTKNDIEIVLNGVDEKSLLRTEQRSAMVAISEQLEQISGSFSGGP 1570

  Fly   944 ---TLRTLVNAFGEL---RTLADEGMLNYPYSTREVVSIVKHLERYPEENMSEVVGNVLDFDRYQ 1002
               .||.|:..:..|   |||.:...|.|...||             .|...|::.::  |::..
 Worm  1571 HSFNLRDLLRWYDLLAAGRTLGEAFELVYMTRTR-------------REEDRELMRSI--FEKMM 1620

  Fly  1003 PEALQQVTQVLAKHGIESYAEEEIQAIRKQRILQASVNRHS-GLGVSGPK-------FGK----- 1054
            .|.|  ||:.|      :...:|    ::.||.:.|:.|.: .|||..|:       |..
 Worm  1621 EEKL--VTKAL------NLTVDE----KEMRIGKCSLKRKTQQLGVQSPRKSLENRLFASQTILM 1673

  Fly  1055 ---------------LDPKNEPHVGGNTWAGGSGGR----DTAGLGGKG-GPFRLDKGHKVHQLS 1099
                           :.|:|            .|.|    :.|.|.||. ....|:......:|.
 Worm  1674 HQIATCVELNWLALLVGPRN------------CGKRSVIENVANLCGKRLRTIALNADTDAQELI 1726

  Fly  1100 DEEKADVPEEIKRAAREMNRKAFEDK------LKEIKMSAHDHKLYAQ----FSEPNRKQVQQLK 1154
            ...:..|.|:....|::...|..|.|      ::::|.:...:||.|.    .||..  .:::::
 Worm  1727 GSYEQVVDEDCLPIAKKQIVKILEHKEAPEAFIEKVKNAGDLNKLEATVELILSEIG--NIEEIQ 1789

  Fly  1155 AVLEAMQTKSKERQW------QKYQTHGD---LDDTRLVEGIT-----------GEKNIYRRRAE 1199
            .||......|...:|      ..| .|||   ::|..|.....           |:..:..|:..
 Worm  1790 DVLNIANQSSMRFEWTDSVFVDAY-LHGDWLLIEDVNLCSAAVLDRLNSCLESGGKLVVAERQNS 1853

  Fly  1200 ANPWADHVQEK--------------------------------PNRLKLVV--DVSGSMYRFNGY 1230
            ..|...|...:                                |:.::.||  .:|..:.|....
 Worm  1854 YEPLEPHPDFRVFLSMDARVGEISRAMRNRSVEIYIEDGWNLWPDDVRTVVGSKMSSELSRIVAR 1918

  Fly  1231 DGRLDRQLEAVVMVMEAFEGFEKKIVYDIIGHSGEGWEIPFVTAGSPPKNDKERFEAIRMMHAHS 1295
            |..:::||....::.|..|.|...:...::|.:.:.|:            |:|
 Worm  1919 DLTVEQQLHLAALLQENGEHFSMDLALKLVGAAQKDWK------------DQE------------ 1959

  Fly  1296 QFCWSGDSTVKAAREACSTLGAEQDYDNAIVVVLSDANLQRYGIAPKDLAMALKRGEPKVKGYAI 1360
                               :...::.:..|:|       :::.||||.|.:....||     |..
 Worm  1960 -------------------IEENEEIEEEILV-------EKFAIAPKILEICNLSGE-----YEK 1993

  Fly  1361 FIGSLAEEADEINAEMPAGQSFVCMDLTKLPHILQQI 1397
            |..|..:.| ..|.:....::.:...|:..|.|||.:
 Worm  1994 FWISTWQRA-AANTKTANVEAILMTFLSSSPWILQNL 2029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:285029	29/105 (28%)
		AAA_5	435..595	CDD:285029	43/176 (24%)
		AAA_5	770..916	CDD:285029	34/165 (21%)
		vWA_F11C1-5a_type	1212..1403	CDD:238732	33/188 (18%)
F55F10.1	NP_001368166.1	MDN1	70..4355	CDD:227596	291/1467 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910