DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment c12.2 and vwa-8

DIOPT Version :9

Sequence 1:	NP_001259381.1	Gene:	c12.2 / 53434	FlyBaseID:	FBgn0040234	Length:	1403	Species:	Drosophila melanogaster
Sequence 2:	NP_510160.2	Gene:	vwa-8 / 181431	WormBaseID:	WBGene00008694	Length:	1804	Species:	Caenorhabditis elegans

Alignment Length:	1864	Identity:	583/1864 - (31%)
Similarity:	877/1864 - (47%)	Gaps:	549/1864 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LRNARIPRRSWASTTAGKDQPEEDSLTIGDVSVRLRKPKDPQLVPQQYADTSRIKETTDLKRRNE 81
            |::||....:.|||::     :..:||||.|||:|:..|:|..||..|.           ::.|.
Worm    10 LQHARKVLTTTASTSS-----KPSTLTIGSVSVQLQDAKNPDFVPAFYG-----------QKNNP 58

  Fly    82 LKYASDGTLQLSQSALHHLRWMLQKDALRQDMFLLGQPGPLRRQLAMQFLELTQREVEYVALSRD 146
                       .|..|.||||::|||.|:||:||||.||.:|.:|.:::||.|.||.||:.::||
Worm    59 -----------PQDLLPHLRWLIQKDKLKQDVFLLGVPGKIRLELVLRYLEATNREFEYLPITRD 112

  Fly   147 TTESDLKQRREINDRAAIFHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGK 211
            |||:|:||||||.|..|.:.|..||||||.|||||:||||.||||||||||||||||||.|:.|:
Worm   113 TTEADIKQRREIRDGTAYYTDLCAVRAALKGRVLVIDGVERAERNVLPILNNLLENREMQLDDGR 177

  Fly   212 FLMSPERYDKLLEKHSREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTY 276
            |||..::||:|..|:....|.:.|:.||||.|.|:|||||..::.|..||||.|||||.||:...
Worm   178 FLMKHDKYDELKVKYDEATLKKMGMERVSENFHVIALGLPVPRFPGNSLDPPFRSRFQCRNIQEL 242

  Fly   277 SYGELYEELQQEAPSVPGEQLKQLLT--FALTLQQADPVLQLPDFPIHNLALGVKMLAANPSLSL 339
            |:....|:.:..||:|....|..|::  :|...:.:....::....:.|.   :|:...|||.|.
Worm   243 SFHTFLEQAKLIAPNVSETNLNDLISVVYAYNSEASTSRPRIGTAVVENT---LKIWNENPSYSA 304

  Fly   340 HDVISRIYPYQTMLKPDQKKRVEELLKKLDI-------QLVPSPSIKKIEAQSQENSLIHIKLDE 397
            .::::..||.:.:|...:|..:.....|.::       :|....::..::..:.:.        :
Worm   305 GEIVNFSYPAKEVLSDSEKDLINTFKTKFELSTHERTRELKTDGALHTVQVPADKR--------K 361

  Fly   398 LQLNLPEGQIPT--ASTYFVDLPHQRQALASLLQAYAVGDVCLVGEKGVGKLTLTQELLRLLQQT 460
            :|:.||....||  |||: :....|...:|.|..|::.||..|:|.||.||..:..||.|.|...
Worm   362 IQMKLPTPSHPTSFASTW-IPTAKQENLIADLALAFSKGDFILIGPKGSGKSRILGELSRRLNFN 425

  Fly   461 SEPMMLYEDMTSRDIVQQRITSPQGDTVWRDSPLVRAAKSGSVAVLNGLHRLHKSTASVLQRLIH 525
            ...|:|::||.:|:::|:|.....|||||.||.||.||::|.|.||:|:..:|.|....|.:||:
Worm   426 YVTMVLHQDMNTRELIQRRHMKENGDTVWEDSILVTAARNGDVCVLDGVEMVHSSVIMSLSQLIY 490

  Fly   526 DRELQLCDGTTLLGANRYQALLQQ-GFSKEELGKLGFLPIHESFRVVALAEPPRLGGGQPSWLTP 589
            .|...|.:|..|:|...:..:::: |..:..:.:.|...|.:||||:.:.|..   ..:..|:..
Worm   491 HRRFDLPNGNRLVGEKEFLTIMERDGVDEATMNERGVFQIPDSFRVLFVGESQ---SKEHKWINE 552

  Fly   590 ELLSLFLYQELRPLRQSEEAELLAQLCGGDLPAGMDQLLKLAQLLRSSQDPLLQGLAGTLSTRQL 654
            .:||:..:..:..|..||:..:::::..|.....:|:|:|..|.:::|.|..|:..|.:||.|:|
Worm   553 NVLSILPFYTVPNLSLSEQMSIISEITHGSNTESVDKLIKFVQTIKNSNDAGLKNTATSLSLRRL 617

  Fly   655 LKLARRLAAYPESELSDVHEMLQNTFLARFMPALSRGALEQAIQQVGIKPREIKLKSKKNQ---- 715
            :.:|:|....|    ..:.|:::...|::|:|.:::...|..:....:. .:..:::|:|:
Worm   618 IHIAKRDLMQP----GHLRELVEKAALSKFLPQITKETFEHELNTANVF-NDTTIRTKENEKFLD 677

  Fly   716 ------IAVEDNSLRIGSTRWPLGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLV 774
                  |..||.:|                   :|:.||:...||.::||.:.:|..:|.||||:
Worm   678 MIRANTIKAEDEAL-------------------IPNVLFHHNKQHDEILEDMARDMKLGSHLLLI 723

  Fly   775 GNQGVGKNKLVDRLLELMQRPREYIQLHRDTTVHSLTLQATLKDGQVSYEDSALVQAVRTGHVLV 839
            ||||||||||.||.|.|:.|||:|:||||||||.:||:|..:::|.:.:||||||:|.|:|.:||
Worm   724 GNQGVGKNKLTDRFLHLINRPRQYMQLHRDTTVQTLTMQTVVENGIIRHEDSALVKAARSGQILV 788

  Fly   840 VDEADKAPVNVTCILRTLVESGEMVLADGRRIVPPG---EGGRVPNSI-ETHPDFRLIVLANRPG 900
            :|||||||::|..||::|:::|.:||.|||.:.|..   |..:..:.| ..||:||:|:||||||
Worm   789 IDEADKAPLHVIAILKSLLDTGTLVLGDGRTLRPASSFTEADKTNDRIVPIHPNFRIIMLANRPG 853

  Fly   901 FPFLGNDFFAALGDVFSCHAISNPDPESEIFLLQQYGPKVPIKTLRTLVNAFGELRTLADEGMLN 965
            ||||||:.||.|||:|:.|.|.:|..:||:.:::::||.||:|||..|:..|.|||...|:|:|.
Worm   854 FPFLGNNLFAVLGDLFAIHMIDHPGRDSELAMIKKFGPTVPVKTLNQLLTIFNELREKTDQGLLQ 918

  Fly   966 YPYSTREVVSIVKHLERYPEENMSEVVGNVLDFDRYQPEALQQVTQVLAKHGI------------ 1018
            |||||||:|:||:|...:|.:.:.||..||.|||.|..:.:..:.:|..|||:
Worm   919 YPYSTRELVNIVRHCNEFPTDPLPEVCRNVFDFDSYSEDTIATIHEVFQKHGVPLGVIRTGESLS 983

  Fly  1019 ------------------------ESY-------------------------------------- 1021
                                    :||
Worm   984 IMERIPLGEMKTIGKWSRQKVEFPKSYGFKTPVAVEIERPEKMEFGLRKLDKQSNRNNVFSELHC 1048

  Fly  1022 ------------------------------------------AEEEI---------QAIRKQRI- 1034
                                                      :.:||         :||.|.||
Worm  1049 VWKLPTDESNIISDGIRINDDLLVASVNPPRLYHCKDFMDTESVDEINIHKIIPRFRAINKPRIR 1113

  Fly  1035 ---------------------------LQASVNRHSGLG-------------------------- 1046
                                       :.|.|.:.:.||
Worm  1114 LAYLGGDNVLLHEEEANFTAIISLPDKMAAVVTKQTSLGETLGAMFTGSNYSWRLSNQQSNHALL 1178

  Fly  1047 ----------------------------------------------------------------- 1046

Worm  1179 YECGGREMLVYTDEKHGVTVQNGTVPFNIKRVFASAPQQWTVVSMENENYLLKVELGNFTLEKID 1243

  Fly  1047 ------------------------------------VSG-------------------------- 1049
                                                |||
Worm  1244 NDLEGGLDTVATKLDKNAMTLVAEPYYFVQGNHSGSVSGVLRKKSENTFHKRPYSFTDDRIAAND 1308

  Fly  1050 ----------------------------------------------------------------- 1049

Worm  1309 VSRENAFLGSTLVRAVPGFMTPTECVEEKIRPFDCIGFLETIDTERKKICYVPVPHSGNISLYQD 1373

  Fly  1050 ----------------------------------------------------------------- 1049

Worm  1374 WVASITKSAFHIVPWDNDKVLTVDSSGSIRSFELRMSTLEKSFDDWKRMTGGADDEKLRMEFDRK 1438

  Fly  1050 -----------PKFGKLDPKNEPHVGGNTWAGGSGGRDTAGLGGKGGPFRLDKGHKVHQLSDEEK 1103
                       ||.||:||.|.||.|||.|.||:||.:||||||.|||||||.||.|||:.|..|
Worm  1439 PDDVDFNKLDEPKLGKIDPNNAPHHGGNQWMGGTGGYNTAGLGGIGGPFRLDAGHDVHQMPDFAK 1503

  Fly  1104 ADVPEEIKRAAREMNRKAFEDKLKEIKMSAHD----HKLYAQFSEPNRKQVQQLKAVLEAMQTKS 1164
            ..||:.|.:.|||:.:..:..||:||.||.:|    .|::.:...|:||    |.:|::.::.|.
Worm  1504 QQVPKHILKKAREIAKVEYAKKLREINMSEYDADAYEKVWNKVQAPSRK----LASVIDQLEAKK 1564

  Fly  1165 KERQWQKYQTHGDLDDTRLVEGITGEKNIYRRRAEANPWADHVQEKPNRLKLVVDVSGSMYRFNG 1229
            |||:|.|:||.|||||.:|:||:|||:||||||.:..|.....|.||.|||:.:|||||||||||
Worm  1565 KEREWTKHQTSGDLDDGKLIEGVTGEQNIYRRRIDKVPDPGAPQTKPKRLKVCLDVSGSMYRFNG 1629

  Fly  1230 YDGRLDRQLEAVVMVMEAFEGFEKKIVYDIIGHSGEGWEIPFVTAGSPPKNDKERFEAIRMMHAH 1294
            ||.||.:.|||.:|.|.|.:|...|:.||||||||:...:.||.....|||:|||.:.::.|.||
Worm  1630 YDQRLVKSLEAALMTMTALDGKTDKVQYDIIGHSGDSPCVSFVKTDHHPKNNKERLDTLKRMIAH 1694

  Fly  1295 SQFCWSGDSTVKAAREACSTLGAEQ-DYDNAIVVVLSDANLQRYGIAPKDLAMALKRGEPKVKGY 1358
            :|:|.|||:||::.:.|...|.|:: |:|..:|:::|||||:||||.||:|..|:.: ||.:..:
Worm  1695 TQYCVSGDNTVESLQFAIKELAAKKDDFDETVVILVSDANLERYGIQPKELKDAMAK-EPNINSF 1758

  Fly  1359 AIFIGSLAEEADEINAEMPAGQSFVCMDLTKLPHILQQIFTSSL 1402
            .||||||::|||::..|:|.|::||..|.::||.|::.||:|::
Worm  1759 VIFIGSLSDEADQLQRELPVGKAFVLKDTSELPKIMETIFSSTI 1802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
c12.2	NP_001259381.1	AAA_5	112..268	CDD:285029	93/155 (60%)
		AAA_5	435..595	CDD:285029	55/160 (34%)
		AAA_5	770..916	CDD:285029	87/149 (58%)
		vWA_F11C1-5a_type	1212..1403	CDD:238732	94/192 (49%)
vwa-8	NP_510160.2	AAA_5	78..234	CDD:336785	93/155 (60%)
		AAA_5	400..556	CDD:336785	53/158 (34%)
		AAA_5	719..869	CDD:336785	87/149 (58%)
		vWFA	1612..1803	CDD:381780	94/192 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158732
Domainoid	1	1.000	465	1.000	Domainoid score	I225
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44881
Inparanoid	1	1.050	1044	1.000	Inparanoid score	I134
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56748
OrthoDB	1	1.010	-	-		D48751at33208
OrthoFinder	1	1.000	-	-		FOG0007423
OrthoInspector	1	1.000	-	-		oto19033
orthoMCL	1	0.900	-	-		OOG6_104715
Panther	1	1.100	-	-	LDO	PTHR21610
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3032
SonicParanoid	1	1.000	-	-		X5558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940