DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment c12.2 and mdn1

DIOPT Version :9

Sequence 1:NP_001259381.1 Gene:c12.2 / 53434 FlyBaseID:FBgn0040234 Length:1403 Species:Drosophila melanogaster
Sequence 2:XP_002940362.3 Gene:mdn1 / 100486293 XenbaseID:XB-GENE-958471 Length:5545 Species:Xenopus tropicalis


Alignment Length:1713 Identity:323/1713 - (18%)
Similarity:544/1713 - (31%) Gaps:610/1713 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 KPKDPQLV--------PQQYADT-SRIKETTDL---------KRRNELKYASDGTLQLSQSALHH 99
            ||.|.:|:        .:.:|.| ||.:..|.|         ||..:|       |:|.|   |.
 Frog   701 KPVDHKLIWLPLREGFEELFAQTFSRKQNQTFLGHIQTCYRQKRWQDL-------LKLMQ---HV 755

  Fly   100 LRWMLQKDALRQDMFLLGQPG---PLRRQLAMQFLELTQREVEYVALSRDTTESDLKQRREINDR 161
            ||..|.|....:..|||.:..   .||...|.|.:.:|:..|.:..:     |..|.|       
 Frog   756 LRSALNKVQTGEAEFLLKEKWEGFSLRLNQAQQQMRMTENAVLFAFV-----EGTLAQ------- 808

  Fly   162 AAIFHDQGAVRAALNGRVLVLDGVEHAERNVLPILNNLLENREMHLESGKFLMSPERYDKLLEKH 226
                       |...|..::||.:..|....|..|..|||.     .||..:        ||::.
 Frog   809 -----------AVKKGEWILLDEINLAAAETLECLCGLLEG-----ISGSLV--------LLDRG 849

  Fly   227 SREQLDEWGLLRVSEQFRVVALGLPTHKYKGTPLDPPLRSRFQSRNVTTYSYGELY-EELQQEAP 290
            ..|.|..      ...||:.|...|........|.|.:|:||.          ||| |||:.|..
 Frog   850 DTEPLVR------HPDFRLFACMNPATDVGKRNLPPGIRNRFT----------ELYVEELENEGD 898

  Fly   291 ------------SVPGEQLKQLLTFALTLQQ------ADPVLQLPDFPIHNLALGVKMLAANPSL 337
                        :|....::.:::|.|.:::      .|.....|.:.:..|...::..:|||  
 Frog   899 LQILIMDYLRGLNVSKTVVQGIISFYLAIRKKSSAELVDGTGHRPHYSLRTLCRALRYASANP-- 961

  Fly   338 SLHDVISRIYP-----YQTMLKPDQKKRVEELLKKLDIQLVPSPSIKKIEAQSQENSLIHIKLDE 397
             .:.|...:|.     :.|.|.......|..|:::..:|    .:||.:.:|.            
 Frog   962 -CNSVQRSLYEGFCLGFLTQLDRASHSVVLGLIRRYILQ----GNIKHLLSQP------------ 1009

  Fly   398 LQLNLPEGQ-----------IPTAS-----------TYFVDLPHQRQALASLLQAYAVG--DVCL 438
                |||.:           ||...           ||.|:|     .|..|::..:.|  .|.:
 Frog  1010 ----LPEPRGSRFVQIQGYWIPVGDKDPAIDESYILTYSVNL-----NLRDLVRVVSAGTHPVLI 1065

  Fly   439 VGEKGVGKLTLTQEL--------LRLLQQTSEPMMLYEDMTSRDIVQQRITSPQGDTVWRDSPLV 495
            .||..|||.:|.:.|        :|:.......:..|....:.|:        .|..::::..|:
 Frog  1066 QGETSVGKTSLIRWLACASGNHCVRINNHEHTDIQEYIGCYTSDV--------SGKLIFKEGVLI 1122

  Fly   496 RAAKSGSVAVLNGLHRLHKSTASVLQRLIHD-RELQLCDGTTLLGANRYQALLQQGFSKEELGKL 559
            .|.:.|...:|:.|:.........|.||:.| |||.:.:...::.|                   
 Frog  1123 DAMRKGYWVILDELNLAPTDVLEALNRLLDDNRELFITETQEVVKA------------------- 1168

  Fly   560 GFLPIHESFRVVALAEPPRLGGGQPSWLTPELLSLFLYQELRPLRQSEEAELLAQLCGGDLPAG- 623
                 |..|.:.|...||.|.||: ..|:....:.|:......|..:|...:|.:.|  .||.. 
 Frog  1169 -----HPRFMLFATQNPPGLYGGR-KVLSRAFRNRFVELHFDELPSAELETILHKRC--CLPPSY 1225

  Fly   624 ----MDQLLKLAQLLRSSQDPLLQGLAGTLSTRQLLKLARRLAAYPESELSDVHEMLQNTFLARF 684
                :..:|:|....|.|.  :..|..|.::.|.|.:.|.|.....::|..  ::.||:.....|
 Frog  1226 CNKLVAVMLELQSYRRGSS--VFAGKHGFITLRDLFRWAERYRLSEQNEKD--YDWLQHLANDGF 1286

  Fly   685 MPALSRGAL-----EQAIQQV-------GIKPREI----KLKSKKNQIAVEDN--SLRIGSTRWP 731
            |  |..|.:     |:.|.:|       .::|:.|    .::.:.:.::|:.:  ..|.....|.
 Frog  1287 M--LLAGRVRKPEEEEVILKVLKKCFKKQVEPQHIFSRGSVQRQLDSLSVQQDIVDFRFSHIVWT 1349

  Fly   732 LGNPTQAQLSKVPHTLFYEMPQHVQLLERLLQDYLIGEHLLLVGNQGVGKNKLVDRLLELMQRPR 796
            .|                 |.:...|:.|.||   .||.:||||:.|.||..:......|..:..
 Frog  1350 QG-----------------MRRLAVLVGRALQ---FGEPVLLVGDTGCGKTTICQLFAALASQTL 1394

  Fly   797 EYIQLHRDTTVHSLT---------LQATLKD-GQVSY------EDSALVQAVRTGHVLVVDEADK 845
            ..:..|:    |..|         ::...|| ..|.|      .|..||.|::.....::||...
 Frog  1395 HCVNCHQ----HMETSDFLGGLRPIRQRSKDKDDVEYSKLFEWHDGPLVLAIKEDGFFLMDEISL 1455

  Fly   846 APVNVTCILRTLVE-SGEMVLADGRRIVPPGEGGRVPNSIE---THPDFRLIVLANRPGFPFLGN 906
            |..:|...|.:::| ...:|||:      .|.|......:|   ....||::...| ||..|...
 Frog  1456 ADDSVLERLNSVLEVEKTLVLAE------KGSGEDETEEVEILTAGKQFRILATMN-PGGDFGKK 1513

  Fly   907 DFFAALGDVFS---CHAISNPDPESEIFLLQQYGPKVPIKTLRTLVNAFGELRTLAD------EG 962
            :...||.:.|:   |...::....:||.       |..:.|..:|.:::.....:||      |.
 Frog  1514 ELSPALRNRFTEIWCPQSNDRHDLAEII-------KHNLHTGLSLGSSYCNGADIADLMMDFIEW 1571

  Fly   963 MLNYPY------STREVVSIVKHLE---------------------------------------- 981
            :.|..:      |.|:::|.|..:.                                        
 Frog  1572 LTNQDFGRRCILSVRDILSWVNFMNVMVGDKDAVNSNAPGADLDAVTAFVHAACLVYIDGLGSGT 1636

  Fly   982 ----------------RYPEENMSEVVGNVLDFDRYQPEALQQVTQ------------------- 1011
                            |:..|.:||::....|. ..:.:...|.||                   
 Frog  1637 TFTSAEAATFARQQCMRFLREKLSEILSLTEDV-HSELKLYDQATQRKICWREDCFGIHPFYIPI 1700

  Fly  1012 --VLAKHGIESYA-EEEIQAIRKQRILQASVNRHSGLGVSGPKFGKLDPKNEPHVGGNT----WA 1069
              ...::.|..|| ..|..::..||:|:|       |.::.|    :..:..|.||..:    .|
 Frog  1701 GPYFQENKITDYALNAETTSMNAQRLLRA-------LQLNKP----IILEGSPGVGKTSLVTALA 1754

  Fly  1070 GGSG------------------GRDTAGLGGKGGPF---------RLDKGHKVHQLSDEEKADVP 1107
            ..||                  |.|....|||||.|         .|..||.:          |.
 Frog  1755 KASGNCLVRINLSEQTDVTDLFGTDLPVEGGKGGEFAWRDGPLLSALKAGHWI----------VL 1809

  Fly  1108 EEIKRAAREM--------NRKAFEDKLKEIKMS---AHDHKLYAQFSEP-----NRK-------- 1148
            :|:..|::.:        :.:| |..:.|:.|:   .|:.........|     .||        
 Frog  1810 DELNLASQSVLEGLNACFDHRA-EVYIPELGMNFQVQHERTKIFGCQNPFHQGGGRKGLPRSFLN 1873

  Fly  1149 -----QVQQL---------KAVLEAMQTKSKERQWQKYQTHGDLDDTRLVEGITGEKNIYRRRAE 1199
                 .|.||         .::..::.|.:..:.   ...:..:|...:||...|:|        
 Frog  1874 RFTQVYVDQLSFADMEFIANSLFPSLGTSTVSKM---VAFNNKIDHQVMVEKKWGQK-------- 1927

  Fly  1200 ANPW-------------------------ADHV--------QEKPNRLKLVVDVSGSMYR----- 1226
            ..||                         |.||        :.||:|.|::     |:|:     
 Frog  1928 GGPWEFNLRDLFRWCQLMLEDQTPDSYDPAQHVFLIYGERMRTKPDREKII-----SVYKEVYGQ 1987

  Fly  1227 ----------------------------------FNGYDGRLDRQLEAVVMVMEAFEGFEKKIVY 1257
                                              |:|:...|...|:::..||:..:        
 Frog  1988 DLTPYLGTRYFYITPQNVQLGYSVLPRSCDSPLSFSGHLSLLHHSLQSLEPVMKCVQ-------- 2044

  Fly  1258 DIIGHSGEGWEIPFVTAGSPPKNDKERFEAIRMMHAHSQFCWSGDSTVKAAREACSTLGAEQDYD 1322
                   .||.:  :..|..........:.:.::..|.....:    :.:|.:....||..:..|
 Frog  2045 -------MGWMV--ILVGPAAVGKTSLVQTLALLTGHKLKIMA----MNSAMDTTELLGGFEQAD 2096

  Fly  1323 -------------NAIVVVLSDANLQRYGIAPKDLAMALKRGEPKVKGYAIFIGSLAEEADEINA 1374
                         ||:..::.|:.|..  .|..|...||.|....:        ||..:...:. 
 Frog  2097 INRPWQQLLEQVGNAVTTLVRDSLLTT--DASPDETEALLRSWTTM--------SLIHKPQSVG- 2150

  Fly  1375 EMPAGQSFVCMDLTKLPHILQQI 1397
              .||.......|.||..:|.||
 Frog  2151 --EAGSGITTDLLNKLEGVLVQI 2171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
c12.2NP_001259381.1 AAA_5 112..268 CDD:285029 35/158 (22%)
AAA_5 435..595 CDD:285029 34/168 (20%)
AAA_5 770..916 CDD:285029 39/165 (24%)
vWA_F11C1-5a_type 1212..1403 CDD:238732 37/238 (16%)
mdn1XP_002940362.3 MDN1 238..>2303 CDD:227596 323/1713 (19%)
PTZ00121 <4638..5267 CDD:173412
vWA_midasin 5272..5542 CDD:238737
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.