DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and Phlpp1

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	361	Identity:	68/361 - (18%)
Similarity:	136/361 - (37%)	Gaps:	69/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 IDFFHYLGFNMMGIFFRIMND---TMVRSSFLDRYQF---ITEEIWLRQARRQESLLLDSILPPQ 270
            ::..|.|.:  :|:.|....|   .:.:.:.:|:...   ..|.:.|:..||.          |.
Mouse   712 LESMHQLSY--LGLSFNEFTDIPEVLEKLTAVDKLCMAGNCVETLRLQALRRM----------PH 764

  Fly   271 IAK-PIQKSIKEKIIQPDNDF-YHLGTSRTAEN---FMSIQIHNDVSILYADLVNYTQLTTTLTV 330
            |.. .::.:|..|::..:.|| .|:......:|   .:...|.|::.:|:.:   ..||.|....
Mouse   765 IKHVDLRLNILRKLMADEVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVLHCE---RNQLVTLNVC 826

  Fly   331 EKLVKVLH---DLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIK 392
            ...:|.|:   :..|:.|:..:...:..:....:|.       ||.|:....:..|      .:.
Mouse   827 GYFLKALYASSNELAQLDVYPVPNYLSYMDVSRNCL-------ESVPEWVCESRKL------EVL 878

  Fly   393 EVSVNRSLNIGMRIGVHSG--TLFAGVIGKAKLQYDIWGADVNI--ASRLEATGSPGYVHVSGRT 453
            ::..|:...:..|:..:|.  .|.||....|:|...:....|.:  ....:.|..|..:.:...:
Mouse   879 DIGHNQICELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEVLDVQHNQITELPPNLLMKADS 943

  Fly   454 LSSLNAEEYNIY---PGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGS 515
            |..|||....:.   |.|.|.:...:||:..::...||       ||.:.::.|.|.|.:..:..
Mouse   944 LRFLNASANKLETLPPATLSEETSSILQELYLTNNCLT-------DKCVPLLTGHPRLKILHMAY 1001

  Fly   516 NR-----KSQILKPNLLSHEMREEFRKMPVGGFKFQ 546
            ||     .|::.|        .||..::.:.|.|.:
Mouse  1002 NRLQSFPASKMAK--------LEELEEIDISGNKLK 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	16/86 (19%)
		CYCc	262..464	CDD:214485	38/213 (18%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	36/192 (19%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406
		PH_PHLPP-like	491..587	CDD:270131
		PH	511..592	CDD:278594
		LRR_RI	581..885	CDD:238064	34/200 (17%)
		LRR_8	594..659	CDD:290566
		LRR 1	594..615
		leucine-rich repeat	597..617	CDD:275380
		LRR 2	617..638
		leucine-rich repeat	618..648	CDD:275380
		LRR_8	647..726	CDD:290566	3/15 (20%)
		LRR 3	648..669
		LRR 4	671..692
		leucine-rich repeat	672..694	CDD:275380
		LRR 5	694..715		0/2 (0%)
		leucine-rich repeat	695..717	CDD:275380	0/4 (0%)
		LRR 6	717..739		4/23 (17%)
		leucine-rich repeat	718..740	CDD:275380	4/23 (17%)
		LRR 7	740..760		3/19 (16%)
		leucine-rich repeat	741..764	CDD:275380	5/32 (16%)
		LRR 8	764..785		3/20 (15%)
		LRR_RI	768..1030	CDD:238064	56/293 (19%)
		leucine-rich repeat	768..788	CDD:275380	4/19 (21%)
		LRR 9	788..809		3/20 (15%)
		leucine-rich repeat	789..809	CDD:275380	2/19 (11%)
		leucine-rich repeat	810..851	CDD:275380	8/43 (19%)
		LRR 10	829..850		4/20 (20%)
		LRR 11	851..872		4/27 (15%)
		leucine-rich repeat	852..874	CDD:275380	4/28 (14%)
		LRR 12	874..895		3/26 (12%)
		leucine-rich repeat	875..897	CDD:275380	3/27 (11%)
		LRR_8	896..954	CDD:290566	13/57 (23%)
		LRR 13	897..918		5/20 (25%)
		leucine-rich repeat	898..919	CDD:275380	5/20 (25%)
		LRR 14	919..940		3/20 (15%)
		leucine-rich repeat	920..943	CDD:275380	3/22 (14%)
		LRR 15	943..964		6/20 (30%)
		leucine-rich repeat	944..967	CDD:275380	7/22 (32%)
		LRR 16	969..989		6/26 (23%)
		LRR_8	970..1028	CDD:290566	16/72 (22%)
		leucine-rich repeat	970..993	CDD:275380	7/29 (24%)
		LRR 17	993..1014		4/20 (20%)
		leucine-rich repeat	994..1017	CDD:275380	5/30 (17%)
		LRR 18	1017..1038		3/13 (23%)
		LRR 19	1040..1061
		LRR 20	1062..1083
		leucine-rich repeat	1063..1085	CDD:275380
		LRR 21	1085..1106
		PP2Cc	1124..1376	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900