Protein Alignment ACXA and Adcy7

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_445848.1
• Gene: Adcy7 / 84420
• RGDID: 619966
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 1180
• Identity: 305/1180 - (25%)
• Similarity: 511/1180 - (43%)
• Gaps: 253/1180 - (21%)

  Fly    46 YMKYKIRLMISSLTVFVPMLILLI-------VALQVIIWSFTEYTKY--IYINAIFDLGSLILVT 101
            |.||::      .:...|:|:||:       :||..|::|..:..::  :...|.|   .|.|..
  Rat    22 YEKYRL------TSQHGPLLLLLLLVAVATCIALVSIVFSHEDLRRHQAVLGTAFF---MLTLFV 77

  Fly   102 GLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAF-----NTYYYYKSNWPLNTLYDVFVLCM 161
            .|..:.:.|  .:..||:........|.:::||.:..     |..|.::     ...:.:|::.:
  Rat    78 ALYVLVYVE--CLAQRWLRVLALLTWACLMILGSVLMWDSLENEAYAWE-----QVPFFLFIVFV 135

  Fly   162 IYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIF 226
            :|:.||: |::||..:.::.::::::.|.......:.:::....||.::: :....||.|..|.|
  Rat   136 VYVLLPL-STRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQLGLQLLA-NAVILLGGNFTGAF 198

  Fly   227 FRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQ------ 285
            .:.......|..|:...:.|.....||..:||:..||.|:||..|:..::.:|.|::.:
  Rat   199 HKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHY 263

  Fly   286 -PDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAAL 349
             |||:|:.|...|          |.:|||||||:|.:|:|.:..:.::||.||::|:.:||..|.
  Rat   264 TPDNNFHSLYVKR----------HQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAK 318

  Fly   350 SFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLF 414
            :.:..|||.||||||||:||..|.|.||...|.:|:.:...||:|.....::|.||:|:|||.:.
  Rat   319 ANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVL 383

  Fly   415 AGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQK 479
            .||||..|.|||:|..||::|:|:||.|.||.||::..||:.|: :.|.:..| ...|:||.|::
  Rat   384 CGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLD-KAYEVEDG-HGEQRDPYLKE 446

  Fly   480 HPMSTYLL----TAIPSLDS--------DKTISIVEGV-------------PNLDLQTVGSNRKS 519
            ..:.|||:    :..|.|.|        |.|:.:...|             |...|....|...|
  Rat   447 MNIRTYLVIDPRSQQPPLPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSS 511

  Fly   520 QILKPN--------LLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVER------------- 563
            :|..||        |..|...:          :...|..|.|.:..:|.:..
  Rat   512 EIPIPNGRRQKAIPLRRHRAPD----------RSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSK 566

  Fly   564 --DLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAF 626
              |...|...|.:|..|..|...|....:|..|....:..|::.:..:....:...|:...::|
  Rat   567 SDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGLSFGLVA- 630

  Fly   627 FVLTFLLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMII--LCYYMV 689
            .:|..:|..|:          ..|..........:..:.|.::...:|||::.::.:  |....:
  Rat   631 CLLGLVLSFCF----------ATEFSRCLPARSTLQAISESVETQPLLRLSLVVVTVGSLLTVAI 685

  Fly   690 ISLIL------------------------MSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNM 730
            |::.|                        ..||...|                :||
  Rat   686 INMPLTFNPGPEQPGDNETSPLAARNRVGTPCELLPY----------------YTC--------- 725

  Fly   731 MALILGM--SYTFARIPFALKTFIGCAEAVVFVLVV----CFQYA-------------------- 769
             :.:||.  ...|.|:...||..:.....|.::|:.    |:|.:
  Rat   726 -SCVLGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLSPCWQVSGNSTETNSTHRTRRLLSAEQ 789

  Fly   770 FIFEHSVTTSPYLKAEIAHSC-------RVCMMLITMYAK----ERQSEFNTKMNYKLNLDLQNK 823
            .:..|::.....:.|....||       .:...|:..||.    .||.::..:::.......:.:
  Rat   790 SMNSHTLALGAQMTAPSPSSCLERDLKTMINFYLVLFYATLILLSRQIDYYCRLDCLWKKKFKKE 854

  Fly   824 QKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQM--------- 879
            .:..:.......:||.|:||:||...::...|..:.|:::|..|.||||.:.:|::
  Rat   855 HEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNK 919

  Fly   880 -DLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLS 943
             .|..||:||:||..||.||...| :..|||||.:|.|||||.||
  Rat   920 EGLECLRLLNEIIADFDELLLKPK-FSGVEKIKTIGSTYMAAAGL-------------------- 963

  Fly   944 SELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTG 1008
                .|.|..|:...|:.|..:. ::..|::.||..|...|:        .:.::..:|:||:.|
  Rat   964 ----SVPSGHENQDLERKHVHIG-VLVEFSMALMSKLDGINR--------HSFNSFRLRVGINHG 1015

  Fly  1009 QIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRG 1073
            .::|||:||.:|.||||||.||:||||||||..|.||||:||...|:.....|..|||..|||:|
  Rat  1016 PVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKG 1080

  Fly  1074 EIPTYFVGID 1083
            |:.||||..|
  Rat  1081 ELRTYFVCTD 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	57/265 (22%)
		CYCc	262..464	CDD:214485	86/208 (41%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	80/186 (43%)
		CYCc	831..1055	CDD:214485	84/233 (36%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	88/230 (38%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	52/246 (21%)
		Guanylate_cyc	272..422	CDD:306677	70/159 (44%)
		DUF1053	487..593	CDD:399378	20/115 (17%)
		Guanylate_cyc	891..1087	CDD:306677	88/229 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880