DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Adcy2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_112269.2	Gene:	Adcy2 / 81636	RGDID:	619965	Length:	1095	Species:	Rattus norvegicus

Alignment Length:	1211	Identity:	313/1211 - (25%)
Similarity:	527/1211 - (43%)	Gaps:	263/1211 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LWEQS-----YLKARCKE-----------LHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVI 75
            :|:::     ||:.|.:.           |....:::......|.....:.|.:|::::.|...:
  Rat     1 MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGACLAL 65

  Fly    76 IWSFTEYTKYIYINAIFDLG--------SLILVTGLLSINFFEDFV------IRHRWVMTFTSTL 126
            :..|            |.||        .||.|...|:| ||..|:      :..:.:..|:..:
  Rat    66 LAVF------------FALGLEVEDHVAFLITVPTALAI-FFAIFILVCIESVFKKLLRVFSLVI 117

  Fly   127 SAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIH 191
            ...:|.:|.: |..:....|.|...:.: :|::.::|..||. :.:.|.:.:|..|.::.|....
  Rat   118 WICLVAMGYL-FMCFGGTVSAWDQVSFF-LFIIFVVYTMLPF-NMRDAIIASILTSSSHTIVLSV 179

  Fly   192 FMA----FNEH-------NVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQF 245
            :::    ..||       ||..::.|              |:.|.:.:.:.:..::.::.|....
  Rat   180 YLSATPGAKEHLFWQILANVIIFICG--------------NLAGAYHKHLMELALQQTYRDTCNC 230

  Fly   246 ITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQI--H 308
            |...|.|...:||:..||.|:||..||..::..|.:::..|     ..|......||.::.:  |
  Rat   231 IKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGP-----KAGQMENTNNFHNLYVKRH 290

  Fly   309 NDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESD 373
            .:|||||||:|.:|:|.:..:..:||.:|::|:.:||..|...:..|||.||||||||:||..|.
  Rat   291 TNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 355

  Fly   374 PDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRL 438
            |:||...|.:|:.|...||:|.....::|.||:|||||.:..||||..|.|||:|..||.:|:.:
  Rat   356 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHM 420

  Fly   439 EATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTY--------------LLTA 489
            ||.|.||.||:|..||..||. .|.:..| :...:||.|::|.:.||              |...
  Rat   421 EAGGVPGRVHISSVTLEHLNG-AYKVEEG-DGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRP 483

  Fly   490 IPSLDSDKTISIVE----------------------------GVPNLDLQTVGSNRKSQILKPNL 526
            ..:||..|..:.|.                            .:...|:.....|.:::.|:...
  Rat   484 RHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKS 548

  Fly   527 LSHEMREEFRK---MPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLHQPDYI 588
            ......||..:   ..:.|...|..|      ||:|.::|    ..:.|.:|::|..|.......
  Rat   549 QKKRFEEELNERMIQAIDGINAQKQW------LKSEDIQR----ISLLFYNKNIEKEYRATALPA 603

  Fly   589 FKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVI----NII------AFFVLTFLLFIC------- 636
            |||.|..     .|||::      .||...:::    :|:      ||..|.|:||:|
  Rat   604 FKYYVTC-----ACLIFL------CIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQ 657

  Fly   637 ----------WYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVIS 691
                      |..|    .||...:|.:.::|..|      :..:.:|.:.|:.|..|......:
  Rat   658 CSKKASTSLMWLLK----SSGIIANRPWPRISLTI------VTTAIILTMAVFNMFFLSNSEETT 712

  Fly   692 LILMSCEK-----DQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTF 751
            |...:...     ...:..|:.::  |....|:     :.|:.::.||  ....|.|:.:.||..
  Rat   713 LPTANTSNANVSVPDNQASILHAR--NLFFLPY-----FIYSCILGLI--SCSVFLRVNYELKML 768

  Fly   752 IGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKA-----------EIAHSCRVCMMLITMYAKERQ 805
            |      :.|.:|.:....:..|:.....|.:.           :...|..:.:..||:....||
  Rat   769 I------MMVALVGYNTILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQ 827

  Fly   806 SEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLS-SIAKHELYYENYRMVSV 869
            ||:..::::......:.:::..:.......:||.|:||:||.|.:|: |:...|||:::|..|.|
  Rat   828 SEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCV 892

  Fly   870 MFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLD 924
            |||.:.:|          :..|..||:||:||..||.|||..| :..|||||.:|.|||||.|
  Rat   893 MFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATG-- 954

  Fly   925 FSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAG 989
                                 |..:.|:..:...|:.:..:. .|..||..|:..|...||
  Rat   955 ---------------------LSAIPSQEHAQEPERQYMHIG-TMVEFAYALVGKLDAINK---- 993

  Fly   990 EPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTL 1054
                .:.:..::|:||:.|.::|||:||.:|.||||||.||:||||:|||:...||||:||:..|
  Rat   994 ----HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLIL 1054

  Fly  1055 EEFDVMCYYRGLTFVKGRGEIPTYFVGIDKDLKFMSKKIDR 1095
            :.....|..||:..|||:|::.||||..:     ||:.:.:
  Rat  1055 QTLGYTCTCRGIINVKGKGDLKTYFVNTE-----MSRSLSQ 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	52/273 (19%)
		CYCc	262..464	CDD:214485	86/203 (42%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	82/198 (41%)
		CYCc	831..1055	CDD:214485	86/234 (37%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	85/230 (37%)
Adcy2	NP_112269.2	AC_N	<37..264	CDD:318454	50/256 (20%)
		Guanylate_cyc	285..469	CDD:306677	81/185 (44%)
		DUF1053	499..603	CDD:399378	16/113 (14%)
		Guanylate_cyc	882..1081	CDD:306677	86/231 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880