DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Gucy2g

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	1250	Identity:	249/1250 - (19%)
Similarity:	412/1250 - (32%)	Gaps:	428/1250 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 LGSLILVTGL----LSINFFEDFVIRHRW--------VMTFTSTLSAYVVVLGDIAFNTYYYYKS 146
            |..::|||.|    |::.|...:.|.|.:        :.|....|::..|.||::::. :.|..|
Mouse    32 LSVVMLVTCLEAAKLTVGFHAPWNISHPFSVQRLGAGLQTVVDKLNSEPVGLGNVSWE-FTYTNS 95

  Fly   147 NWPLNTLYDVFV-----LCMIYMFLPI--PSSKAAALLAISVSLTYVIYFIHFMAFNEH------ 198
            .........||:     ..:..:|.|.  .:::...|||...::....:.....|..:|
Mouse    96 TCSAKESLAVFIDQVQKEHISALFGPACPEAAEVIGLLASEWNIPLFDFVGQMAALKDHFWCDTC 160

  Fly   199 -NVAKYVHGLDIVSIDFFHYLGFNMMGIF--------------------------FRIMNDTMVR 236
             .:......:..|..:...|||:..:|:|                          |.|.......
Mouse   161 VTLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWGAVEDGLQFHFNITASMRYN 225

  Fly   237 SSFLDRYQ-------FITEEIWL----RQARR----------------------------QESLL 262
            ||..|..|       ::...|.|    ..|||                            :|.|.
Mouse   226 SSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFILLQQLEDSFWKEVLT 290

  Fly   263 LDSILP-PQIAKPI-----------------QKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHN 309
            .|.::. |::.:.:                 :|.:.:::.:|  .|....||....:..|..:|
Mouse   291 KDKVIRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRP--PFQSSITSEDQVSPYSAYLH- 352

  Fly   310 DVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAG------ 368
            |..:|||.           |||::.|...|......|.: :.:..::...|     :.|
Mouse   353 DALLLYAQ-----------TVEEMRKAEKDFRDGRQLIS-TLRAGQVTLQG-----ITGPVLLDS 400

  Fly   369 LGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDI------ 427
            .|:...|::..|:           :.|.||||.:..                  |.||.
Mouse   401 QGKRHVDYSVYAL-----------QESGNRSLFLPF------------------LHYDSFQKVIR 436

  Fly   428 -WGADVNIA----SRLEATGSPGYVH---------VSGRT--------------LSSLNAEEYNI 464
             |..|.|.:    |..|.....|:.:         |:|.|              |:|..|
Mouse   437 PWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAA----- 496

  Fly   465 YPGTESAQKDPVLQKHPMSTY------LLTAIPSLD--------SDKTISIVEGVPNLDLQTVGS 515
            ..|....:....:|.||..|:      .:|.:|...        |.:.:|        |..||
Mouse   497 ITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVS--------DTSTV-- 551

  Fly   516 NRKSQILKPNLLSHEMREEFRKMPVGGFK----------------FQFPWSRRE----RNLKNEK 560
              |:.....:|:.....||....|||.::                .:.|..|||    ..||:|.
Mouse   552 --KASADCGSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHEN 614

  Fly   561 VERDLGI------------FCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSD 613
            :....|:            :|.....:.|..|..|:.|:|||.|.|            ..:.|..
Mouse   615 IVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFA------------YDIVNGL 667

  Fly   614 IFYTGVVIN-----------IIAFFVLTFLLFICW-YKKVCWWHSGQNEHRSYGKLSCAIFHLFE 666
            :|..|..:.           :.:...|....|..| :|....|.|...|...:.:|......|
Mouse   668 LFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPEL-- 730

  Fly   667 KIQHSFVLRL-----------TVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFT 720
                   |||           .||...||    :..||.........:|:....::.:...||
Mouse   731 -------LRLRESPCSGTPQGDVYSFAIL----LRDLIHQQAHGPFEDLEAAPEEIISRIKDP-- 782

  Fly   721 CFHPWAYTNMMALILGMSYTFARIPFALKTFI----GCAEAVVFVLVVCFQYAFIFEHSVTTSPY 781
                                  |.|..|:..:    |....|..|. .|:.          .||.
Mouse   783 ----------------------RAPVPLRPSLLEDKGDGRIVALVR-ECWD----------ESPE 814

  Fly   782 LK---AEIAHSCRVC------MMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIIL 837
            |:   ..|..:.|..      .:|.:|..|     ..|..|: |...::.:.:......:.:..|
Mouse   815 LRPIFPSIKKTLREASPRGHVSILDSMMGK-----LETYANH-LEEVVEERTRELVAEKRKVEKL 873

  Fly   838 LNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNF------QMDLPSLRVLNDIITAFDR 896
            |:.:|||.|.|   ..||...:..|::..|::.|:.:..|      ...|..:::|||:.:.||.
Mouse   874 LSTMLPSFVGE---QLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDH 935

  Fly   897 LLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKN 961
            .:.::..|    |::.:|..||.|.||                        .:|:..:.:
Mouse   936 TIQSHDVY----KVETIGDAYMVASGL------------------------PIRNGAQHA----- 967

  Fly   962 HDEVAFIMATFALDLMRVLSVCNKAYAGE-PFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIW 1025
             ||:    ||.||.|   |||......|. |.:|.    ::|||:.||.::|||||.:.|.|.::
Mouse   968 -DEI----ATMALHL---LSVTTHFQIGHMPEERL----KLRIGLHTGPVVAGVVGITMPRYCLF 1020

  Fly  1026 GNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYY---RGLTFVKGRGEIPTYFV----GID 1083
            |:.|||||||||:.|...|.|::.||..|  .....|:   ||...|||:||..|:::    |..
Mouse  1021 GDTVNMASRMESSSLPLRIHVSQSTAGAL--LAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFP 1083

  Fly  1084 KDLKFMSKKIDRLSE 1098
            ..|...:::..::||
Mouse  1084 VPLPEFTEEEAKVSE 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	48/305 (16%)
		CYCc	262..464	CDD:214485	44/259 (17%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	41/228 (18%)
		CYCc	831..1055	CDD:214485	68/230 (30%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	69/230 (30%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	70/438 (16%)
		PK_GC	555..829	CDD:270894	60/333 (18%)
		CYCc	865..1055	CDD:214485	69/239 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900