DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	254	Identity:	64/254 - (25%)
Similarity:	120/254 - (47%)	Gaps:	30/254 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 LRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYA 316
            |.:.:::...||.||.|..:|:.:.:  ::::              .|..|      :||::|::
  Rat   481 LEEEKKKTVDLLYSIFPGDVAQQLWQ--RQQV--------------QARKF------DDVTMLFS 523

  Fly   317 DLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAV 381
            |:|.:|.:....|..:::.:|::||.|||.......:.:::.:||.|...:||......||....
  Rat   524 DIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIA 588

  Fly   382 SLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGY 446
            .:.:.|:...:||.......|.||||:|||::.|||:|....:|.::|.:|.:||:.|:...|..
  Rat   589 LMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRR 653

  Fly   447 VHVSGRTLSSLNAEE-YNIYPGTESAQKDPVLQKHPMSTYLL-------TAIPSLDSDK 497
            :::|..|...|..|: :...|.:.....|...::.|...|.|       ...|||.|.:
  Rat   654 INISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPKPSLSSSR 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	7/38 (18%)
		CYCc	262..464	CDD:214485	54/202 (27%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	51/190 (27%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	6/19 (32%)
		CYCc	483..672	CDD:214485	54/210 (26%)
		Guanylate_cyc	512..696	CDD:278633	52/189 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810