Protein Alignment ACXA and Adcy5

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_072122.2
• Gene: Adcy5 / 64532
• RGDID: 71014
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1171
• Identity: 302/1171 - (25%)
• Similarity: 512/1171 - (43%)
• Gaps: 274/1171 - (23%)

  Fly    42 LEEEYMKYKIRLMISSLTVFVPMLILLIVA----------LQVIIWSFTEYTKYIYINAIFDLGS 96
            ||..|.:|..||..||||:.:.:|:|:.:.          |||           :|:..:.....
  Rat   227 LERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQV-----------VYLAVLAAAVG 280

  Fly    97 LILVTGLL--SINFFEDFVIRHRWVMTFTSTLSAYVV---VLGDIAFNTYYYYKSNWPLNTLYDV 156
            :||:..:|  ...|.:|    |..:..:  .|.|.|:   |:|.:........:..|     :.|
  Rat   281 VILIMAVLCNRAAFHQD----HMGLACY--ALIAVVLAVQVVGLLLPQPRSASEGIW-----WTV 334

  Fly   157 FVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFN 221
            |.:..||..||: ..:||.|..:.:|..::...:|..|.::..:.:.|..:.|.|..       |
  Rat   335 FFIYTIYTLLPV-RMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCT-------N 391

  Fly   222 MMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQP 286
            ::|:......:...|.:|.:..:.|...:..::..:|:..||.|:||..:|..::..|..|  |.
  Rat   392 IVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK--QE 454

  Fly   287 DNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSF 351
            |..|:.:          .||.|::||||:||:..:|.|.:..|.::||..|::|:||||..|...
  Rat   455 DMMFHKI----------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAEN 509

  Fly   352 KVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAG 416
            ...|||.||||||||:||.|:..|||...|.:|:.||..|..|.....:|:.||:|:|||.:..|
  Rat   510 HCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG 574

  Fly   417 VIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHP 481
            |:|..|.|:|:|..||.:|:.:||.|..|.:|::..||:.||. :|.:.||. ..:::..|::|.
  Rat   575 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNG-DYEVEPGC-GGERNAYLKEHS 637

  Fly   482 MSTYLL-----------TAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMREEF 535
            :.|:|:           ..|..::..:|.||....|:...:....|.    |..|.:|.||:.
  Rat   638 IETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNH----LGGNQVSKEMKR-- 696

  Fly   536 RKMPVGGFKFQFPWSRRERNLKN--EKVERDLG-----------------IFCVAFKDKSVEWNY 581
                   ..|:.|..:..:...|  ::|:..||                 .|.:.|::..:|..|
  Rat   697 -------MGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY 754

  Fly   582 LHQPDYIFKYSVALGWGIGC--------CLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWY 638
            ..|.|..|      |..:.|        |.:.|..|.:|        :.:::|::..|||
  Rat   755 SKQVDDRF------GAYVACASLVFLFICFVQITIVPHS--------LFMLSFYLSCFLL----- 800

  Fly   639 KKVCWWHSGQNEHRSYGKLSCAIF----------------HLFEKIQHS---------FVLRLTV 678
                              |:..:|                .|..||..|         |.:.| |
  Rat   801 ------------------LALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITL-V 846

  Fly   679 YMMIILCYYMVISLILMSCEKDQYELDI-------IESKLYNY---DMDPF------TCFHPWAY 727
            ::...:..:|..|..|:.|..:::.:.:       :....:||   |...|      .|..|..:
  Rat   847 FLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYF 911

  Fly   728 TNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHS---VTTS---------- 779
            |..:.|.|.....|.:|....|..:..|..:::||:|......:|:::   ||.:
  Rat   912 TYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTS 976

  Fly   780 --PYLKAEIAHSCRVCMMLIT----------MYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQ 832
              |      .|:.:|.:.::|          :|...:|.|...::::...|....:::..:....
  Rat   977 QCP------EHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQA 1035

  Fly   833 SIIILLNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNFQ---MDLPS-------LRV 886
            ....||:||||..|...:|:...:: ||||::...|:||||.:.||.   ::|.:       ||:
  Rat  1036 YNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL 1100

  Fly   887 LNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRS 951
            ||:||..||.::|. .::..:||||.:|.|||||.||:.|..:..      |.|.:.:
  Rat  1101 LNEIIADFDEIISE-DRFRQLEKIKTIGSTYMAASGLNDSTYDKA------GKTHIKA------- 1151

  Fly   952 RLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVG 1016
                             :|.||:.||..:...|        :.:.:..:::||::.|.::|||:|
  Rat  1152 -----------------LADFAMKLMDQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIG 1191

  Fly  1017 ASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTL--EEFDVMCYYRGLTFVKGRGEIPTYF 1079
            |.:|.||||||.||:||||:|||:...||||.:..|.|  ..:.:.|  ||:..|||:||:.|||
  Rat  1192 ARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYF 1254

  Fly  1080 V 1080
            :
  Rat  1255 L 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	59/263 (22%)
		CYCc	262..464	CDD:214485	82/201 (41%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	76/193 (39%)
		CYCc	831..1055	CDD:214485	80/236 (34%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	81/232 (35%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	59/263 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..634	CDD:306677	73/184 (40%)
		DUF1053	669..761	CDD:399378	19/104 (18%)
		Guanylate_cyc	1063..1257	CDD:306677	82/234 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910