DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and Adcy3

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_570135.2	Gene:	Adcy3 / 64508	RGDID:	71009	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	1181	Identity:	318/1181 - (26%)
Similarity:	529/1181 - (44%)	Gaps:	216/1181 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 HLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIY--INAIFDLGSLILV-TG 102
            :|.:.|.|.:....:..|.||..:....:|.:..:::|..:....:.  :..:.|:...:|. .|
  Rat    64 NLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCKKG 128

  Fly   103 LLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTL-YDVFVLCMIYMFL 166
            ||........|....|:: .|:.:.:|      :..|   :.:::...:|: :..|.:...::.|
  Rat   129 LLPDRVSRKVVPYLLWLL-ITAQIFSY------LGLN---FSRAHAASDTVGWQAFFVFSFFITL 183

  Fly   167 PIPSSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMN 231
            |:..|....:..:|..:..::..: .:|..:.:..:.:..|..:..:.|.||...::||....|.
  Rat   184 PLSLSPIVIISVVSCVVHTLVLGV-TVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMA 247

  Fly   232 DTMVRSSFLDRYQFITEEIWL-RQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGT 295
            |...|.:||:..|.:..::.| .|:::||:|:| ||||..:|..:.|.:|:...|.|...:
  Rat   248 DRKHRKAFLEARQSLEVKMNLEEQSQQQENLML-SILPKHVADEMLKDMKKDESQKDQQQF---- 307

  Fly   296 SRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLG 360
                 |.|.:..|.:||||:||:|.:|||::..:.::|||:|::|:||||..|..:...|||.||
  Rat   308 -----NTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILG 367

  Fly   361 DCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQY 425
            |||||:.||.:...|||..::.:|::|:..|..|.......:.||:|||:||:..||:|:.:.||
  Rat   368 DCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQY 432

  Fly   426 DIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLL--- 487
            |:|..||.:|:::||.|.||.||:|..|:..|.. |:::.||...::.| .|.:..:.|||:
  Rat   433 DVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKG-EFDVEPGDGGSRCD-YLDEKGIETYLIIAS 495

  Fly   488 ------TAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQIL----KPNLLSH---EMREEFRKMP 539
                  ||...|:..   ::..|.|       .|...|..|    :||..:|   ...||..:..
  Rat   496 KPEVKKTAQNGLNGS---ALPNGAP-------ASKPSSPALIETKEPNGSAHASGSTSEEAEEQE 550

  Fly   540 VGGFKFQFPWSRRERNLK--------------------NEKV----------ERDLGIFCVAFKD 574
            .......||..||...|:                    ||.:          :|:..:..:.|.|
  Rat   551 AQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMD 615

  Fly   575 KSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQS----------VNNSDIFYTGVVINII----- 624
            ..:|..|..:.:   |.|.| .:...|.:::..:          :.|...|..|.|:.:|
  Rat   616 PEMETRYSVEKE---KQSGA-AFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICS 676

  Fly   625 --AFFVLTF----LLFICWYKKVCWWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMII 683
              |.|...|    :.|..|..:..|      ...::..|  |||.|        |:...|.|:..
  Rat   677 MAAIFPRAFPKKLVAFSSWIDRTRW------ARNTWAML--AIFIL--------VMANVVDMLSC 725

  Fly   684 LCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFAL 748
            |.|||....:....|.|...::  ..|.|||          .|..:::|.|:.:..:. .:...|
  Rat   726 LQYYMGPYNVTTGIELDGGCME--NPKYYNY----------VAVLSLIATIMLVQVSH-MVKLTL 777

  Fly   749 KTFIGCAEAVVFVLVVC----------FQ-----YAFIFEHSVTTSPYLKAEIA--------HSC 790
            ...:..|...:.:...|          ||     ...:.:..|.::|.|....:        :|.
  Rat   778 MLLVTGAVTAINLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSM 842

  Fly   791 RVCM--MLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSS 853
            .|.|  |:::.|...|..|...:..:...:::.::::......:....|:.|:||.||...:|.|
  Rat   843 TVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGS 907

  Fly   854 IAK-HELYYENYRMVSVMFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVV 907
            ..: .|||.::|..:.||||.|.||          ...:..||.||:||:.||.||...| :.|:
  Rat   908 KKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPK-FRVI 971

  Fly   908 EKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEK-NH--DEVAFIM 969
            .|||.:|.|||||.|:      ..|.|:| |.||.|.|        |.|.||: .|  |     :
  Rat   972 TKIKTIGSTYMAASGV------TPDVNTN-GFTSSSKE--------EKSDKERWQHLAD-----L 1016

  Fly   970 ATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASR 1034
            |.|||.:...|:..|        :::.:...:|||::.|.::|||:||.:||||||||.||:|||
  Rat  1017 ADFALAMKDTLTNIN--------NQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASR 1073

  Fly  1035 MESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFV-GIDKDLKFMSKKIDRLSE 1098
            |||||:.|:|||.:||...|.|:......||..||||:||:.|:|: |.|:...|         .
  Rat  1074 MESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAF---------P 1129

  Fly  1099 NPSNPDLNHDL 1109
            |.|:..|.|.:
  Rat  1130 NGSSVTLPHQV 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	52/253 (21%)
		CYCc	262..464	CDD:214485	80/201 (40%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	75/191 (39%)
		CYCc	831..1055	CDD:214485	94/237 (40%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	96/233 (41%)
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	51/250 (20%)
		Guanylate_cyc	310..494	CDD:306677	76/185 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..563		13/68 (19%)
		Guanylate_cyc	914..1121	CDD:306677	97/235 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810