DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and npr3

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio

Alignment Length:	172	Identity:	34/172 - (19%)
Similarity:	58/172 - (33%)	Gaps:	41/172 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 RTAENFMSIQIH---NDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKF 358
            :.||.|.:|..|   ....::|.|  :..:.....|:|.:..||.:.:...|.|.|:...:|:
Zfish   150 KMAETFQAIFGHFGWRTAYLIYDD--DKDERNCYFTMEGVFTVLSEYHISTDFAVLNSNEERV-- 210

  Fly   359 LGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKL 423
                          |||....:| .|..::....:..:.|.|    .:..|          :.||
Zfish   211 --------------DPDGIITSV-YGSEVVIMCSKADIVRDL----MLAAH----------RRKL 246

  Fly   424 QYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIY 465
            .     :|.:|...:|...|..|...|.|.....:.|....|
Zfish   247 T-----SDSHIFFNIELFNSSSYGDGSWRRRDKYDDEARAAY 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485	33/169 (20%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	30/163 (18%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	34/172 (20%)
		ANF_receptor	46..389	CDD:279440	34/172 (20%)
		TM_EphA1	436..468	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900