DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and gucy2cb

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_021329920.1	Gene:	gucy2cb / 568219	ZFINID:	ZDB-GENE-130531-31	Length:	1071	Species:	Danio rerio

Alignment Length:	1252	Identity:	258/1252 - (20%)
Similarity:	415/1252 - (33%)	Gaps:	420/1252 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLL------- 104
            |.|:|.|.:.....|:...:|:               |...:|     |:|::...||
Zfish     1 MDYRIWLFVCFSWAFLKQSLLM---------------KESCLN-----GTLLINVVLLDDDVSPW 45

  Fly   105 SINFFEDFVIR---HRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVL------- 159
            ||||.:..|:|   ....:.|...::..|...|   |.|.||.|:....:....|.:|
Zfish    46 SINFVKPAVMRAVESDSEINFKDGVNLSVSFRG---FQTIYYQKTGCSSSACEGVEILNDLANAG 107

  Fly   160 ----------CMIYMF------------LPIPSSKAAALLA-ISVSLTYVI--------YFIHFM 193
                      |....|            :||.|:.:..|.. :...||.::        :||:|.
Zfish   108 EEGCALLGPTCTYATFQMADLEIGLNLNMPIISAGSFGLSCDLKRDLTRLLPPARKISSFFINFW 172

  Fly   194 AFNEHNVAK------YVHGLDIVSIDFFHYL--------GFNMMGIFFRIMNDTMVRSSFLDRYQ 244
            .|  |:..|      |::.....:.|.|.|:        ||                |..|...:
Zfish   173 KF--HDPVKPKWETAYLYKKPDNTEDCFWYINALEVSNGGF----------------SPSLQEIE 219

  Fly   245 FITEEIWLRQA----RRQESLLLDSILPPQI------AKPIQKSIKEKIIQPDNDFYHLGTSRTA 299
            .|..:..|.:|    .|:.:|.:....|..|      .......|...:|...||.|:.|.|.|
Zfish   220 VIRNKEDLTKAMAKHNRESNLFILCGTPDDIMDLKNGTTDYDSEIAFLLIDLYNDIYYKGQSNT- 283

  Fly   300 ENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYY 364
              ||.       ::|...:.|..:.|...:..   ..::|..|.:..|.|.|        |....
Zfish   284 --FMR-------NVLVLTMPNTRKYTIDTSGN---NTMNDYIAAYHDAVLLF--------GQVMR 328

  Fly   365 CVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWG 429
            .:...|..|              |.:::.||:|...|:.          |.|:.|:.:|...
Zfish   329 NIQKSGSLD--------------IQDMESVSMNYFRNVS----------FTGIAGEYQLDQH--- 366

  Fly   430 ADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNI-YPGTESAQKDPVLQKHPMSTYLLTAIPSL 493
            .|.::...|..|.               |..:||| |....|..|..:....| |....:.:|:.
Zfish   367 GDRDLMFSLIYTN---------------NNNQYNILYQFNTSNNKTGLKDSSP-SFIWQSRLPND 415

  Fly   494 DSDKTISIVEGVPNLDLQTVG-----------------------SNRKSQILKP------NLLSH 529
            ...|.:|::|.:..:....:|                       |:..||::.|      |::|.
Zfish   416 SPSKGLSVIEIIVIVLCTVIGIMGTLAFIFYWQNRYYHHMQKRWSHISSQLITPLELNEWNMISL 480

  Fly   530 EMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKS-VEWNYLHQPDYIFKYSV 593
            ::.|:..:......       ||.|..|...:.::..:...:|.:|. :|.|.|.:.||
Zfish   481 KIEEDSTENSTYIL-------RRARYDKKIVILKEFRLTDGSFTEKQRIELNTLLKIDY------ 532

  Fly   594 ALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFF------VLTFLL----------FICWYKKVC 642
                   |.|.........|..|.||       |      .|.::|          |:.|..|:.
Zfish   533 -------CNLTKFYGTVKFDNEYFGV-------FEYGERGSLRYVLDDKISYPEETFMDWQFKIS 583

  Fly   643 WWH---SGQNE-HRS----YGKL---SCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLIL-- 694
            ..:   .|.:. |.|    :|:|   :|.       :.:..|:::..:     .:..::|...
Zfish   584 VMYDIAKGMSYLHTSNIAVHGRLKSTNCV-------VDNRMVVKIADF-----GFNTIVSPSEDL 636

  Fly   695 -----------MSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTN-------MMALILGMSYT- 740
                       :|.:.|.|...||..::.   |...|     .|||       .:|.:...|.|
Zfish   637 WTAPEHLRKPGISQKGDVYSFAIISQEIM---MRKCT-----FYTNTCSDRAEKLARVQYPSTTS 693

  Fly   741 FARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIA-----------HSCRVCM 794
            |.|.....::.....|.|..::..|:.     |.......:.|.|||           |...:..
Zfish   694 FFRPDLNFESTSESEEEVCMLIRNCWD-----EDPDRRPDFKKIEIALWKIVSRDNQEHESYMEN 753

  Fly   795 ML--ITMYAK--ERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIA 855
            ::  :.||::  ||..|..|.: ||...|      .||..|..       :||..||. .|....
Zfish   754 LIRRLQMYSRNLERLVEERTAL-YKAERD------RADCLNFM-------LLPGPVVR-SLKETG 803

  Fly   856 KHE--------LYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKV 912
            |.|        :|:.:.    |.|..|.:|...:..:.:||||...||.:|..:..|    |::.
Zfish   804 KVEPELFDEVTIYFSDI----VGFTTLCHFSTPMEVVDMLNDIYKNFDSILDNHDVY----KVET 860

  Fly   913 VGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLM 977
            :|..||...||                                  ..:|.:..|..:...|||::
Zfish   861 IGDAYMVVSGL----------------------------------PRRNGNRHAKDICLMALDIL 891

  Fly   978 RVLSVCNKAY-AGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLS 1041
            ..:.....:: .|.|.       .||||:.:|...|||||...|.|.::|:.||.|||||||||.
Zfish   892 AFMGTIQLSHLPGIPV-------WIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 949

  Fly  1042 GHIQVTKETAQTLEEFDVMCYY--RGLTFVKGRGEIPTY--------------------FVGIDK 1084
            ..|.|::.|...|:..|....|  ||.||:||:|:..||                    |..:.:
Zfish   950 LRIHVSQSTINILQRTDCKFEYEERGETFLKGKGKEMTYWLTGVTGENYNLPTPPTAENFQNLQQ 1014

  Fly  1085 DLKFMSKKIDRLSENPS 1101
            ||..|.|..  |.:.||
Zfish  1015 DLSEMIKTC--LQKRPS 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	61/315 (19%)
		CYCc	262..464	CDD:214485	37/207 (18%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	32/183 (17%)
		CYCc	831..1055	CDD:214485	61/232 (26%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	65/243 (27%)
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556	89/459 (19%)
		PKc_like	471..741	CDD:328722	57/321 (18%)
		CYCc	778..970	CDD:214485	66/254 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000