Protein Alignment ACXA and adcy2a

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: XP_692173.5
• Gene: adcy2a / 563724
• ZFINID: ZDB-GENE-061109-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1130
• Identity: 311/1130 - (27%)
• Similarity: 501/1130 - (44%)
• Gaps: 245/1130 - (21%)

  Fly    97 LILVTG----LLSINF-----FEDFVIRHRWVMTFTSTLSAY---------------------VV 131
            |::|.|    ||::.|     .||.|   .:|:|..:.|:.:                     :|
Zfish   110 LLIVMGACLALLAVFFASGLDIEDHV---AFVITVPTALAIFLTIFVLVCIESVFKKLLRVFSLV 171

  Fly   132 VLGDIAFNTYYYYKSN-----WPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIH 191
            :.|.:....|.:....     |...:.: :|::.::|..||.....|.....::.|...|:..:.
Zfish   172 IWGCLVAMGYLFMFFGGIICPWDQVSFF-LFIIFVVYTMLPFSMRDAIIASVLTASSHTVVLSVC 235

  Fly   192 FMAFNEH----------NVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFI 246
            ..:...|          ||..::.|              |:.|.:.:.:.:..::.::.|....|
Zfish   236 LSSTVSHVEPLVWQILANVIIFICG--------------NVAGAYHKHLMELALKQTYQDTCNCI 286

  Fly   247 TEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENF--MSIQIHN 309
            ...|.|...:||:..||.|:||..||:.::..|.:::..|     ..|......||  :.:|.|.
Zfish   287 KSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGP-----KFGQVENTNNFHNLYVQRHT 346

  Fly   310 DVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDP 374
            :|||||||:|.:|:|.:..:..:||.:|::|:.:||..|...:..|||.||||||||:||.||.|
Zfish   347 NVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPESLP 411

  Fly   375 DHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLE 439
            :||...|.:|:.|...||:|.....:.|.||:|||||.:..||||..|.|||:|..||.:|:.:|
Zfish   412 NHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME 476

  Fly   440 ATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEG 504
            |.|.||.||::..||..||. .|.:..| ...::||.|::|.:.|||:.. |.::..........
Zfish   477 AGGVPGRVHITSETLEHLNG-AYKVEDG-HGQERDPYLKEHGVITYLVIN-PKVERKSPQHYYRP 538

  Fly   505 VPNLDLQTVGSNRKSQI-----------LKPNLLSH---EMREEFRK-----MPVGGFKFQFPWS 550
            ...:|    |:..::.:           .||....|   .|..|..|     :|:|.:.||   .
Zfish   539 RHTID----GAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENGKINTADVPIGQYHFQ---R 596

  Fly   551 RRERN----------------------------LKNEKVERDLGIFCVAFKDKSVEWNYLHQPDY 587
            |.||.                            ||:|.::| :.:|   |.:|::|..|......
Zfish   597 RSERTKSQKKRFEEELNERMIRTFDGINSQKQWLKSEDIQR-ISLF---FHNKALEKEYRATTLP 657

  Fly   588 IFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWY------KKVC---W 643
            .|||.:.....|..|:..:|.:........||... ::|.:|:.:|.:|:.      ||..   |
Zfish   658 AFKYYITCACLIFFCIFIVQILVLPKTAILGVSFG-MSFLILSVILLVCFIGHFLQCKKTASASW 721

  Fly   644 -W---HSGQNEHRSYGKLS-----------CAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLI 693
             |   .||....:.:.:::           .|:|::| .|:.:..|..|||
Zfish   722 VWILRSSGIIASKPWPRITLTMATTALILIMAVFNMF-FIEDNLTLMETVY-------------- 771

  Fly   694 LMSCEKDQYELDIIESKLYNYD------MDPFTCFHPW-AYTNMMALILGMSYTFARIPFALKTF 751
                       :.....|...|      :|..|.:.|: .|:.::.||  ....|.||.:.||..
Zfish   772 -----------NTSNETLLQPDGQPIPYLDKNTFYLPYFIYSCILGLI--SCSVFLRINYELKML 823

  Fly   752 IGCAEAVVFVLVVCFQYA--------FIFEHSVTTSPYLKAEI--AHSCRVCMMLITMYAKERQS 806
            |.....|::.:::...:|        |:::..|...|.:..::  ..|..:.:..||:....||:
Zfish   824 IMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIFFITLLVLARQN 888

  Fly   807 EFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHE-LYYENYRMVSVM 870
            |:..::::......:.:.:..:.......:||.|:||:||.|.:|:...|:| ||:::|.:|.||
Zfish   889 EYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDLYHQSYDLVCVM 953

  Fly   871 FAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDF 925
            ||.:.:|          :..|..||:||:||..||.|||..| :..|||||.:|.|||||.||
Zfish   954 FASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGSTYMAATGL-- 1015

  Fly   926 SLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGE 990
                    |:..|     .|..|...|....|.         .|..||..|:..|.|.||
Zfish  1016 --------NATPG-----PEYTQEHDRQYMHIG---------TMVEFAFALVGKLDVINK----- 1053

  Fly   991 PFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLE 1055
               .:.:..::|:||:.|.:.|||:||.:|.||||||.||:||||:|||:.|.||||:||:..|:
Zfish  1054 ---HSFNDFKLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCILQ 1115

  Fly  1056 EFDVMCYYRGLTFVKGRGEIPTYFV 1080
            .....|..||:..|||:||:.||||
Zfish  1116 TLGYTCSCRGIINVKGKGELKTYFV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	44/238 (18%)
		CYCc	262..464	CDD:214485	87/203 (43%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	83/182 (46%)
		CYCc	831..1055	CDD:214485	92/234 (39%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	92/230 (40%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	42/226 (19%)
		CYCc	295..498	CDD:214485	88/208 (42%)
		Guanylate_cyc	340..524	CDD:278633	83/185 (45%)
		DUF1053	554..658	CDD:283888	22/110 (20%)
		CYCc	912..1120	CDD:214485	93/240 (39%)
		Guanylate_cyc	942..1141	CDD:278633	94/232 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880