Protein Alignment ACXA and adcy6b

DIOPT Version :10

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: XP_002666536.2
• Gene: adcy6b / 560807
• ZFINID: ZDB-GENE-090127-2
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1165
• Identity: 302/1165 - (25%)
• Similarity: 499/1165 - (42%)
• Gaps: 259/1165 - (22%)

  Fly    38 KELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTG 102
            |...||..|.:|..||..||||:.  |.:|::|...::.:...:....:...::..:...:.:|.
Zfish   140 KSAKLERLYQRYFFRLNQSSLTML--MGVLVVVCGVMLAFHCVQGPPDVAYASVLSVAMGLFLTL 202

  Fly   103 LLSIN---FFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYM 164
            ::..|   |.:|::    |::::. .:...|||.   .|........:.|....:.||.:.:||.
Zfish   203 MVVCNRNGFHQDYM----WIVSYL-VMGVLVVVQ---VFGLLMVDPPSMPEGIWWTVFFIYIIYT 259

  Fly   165 FLPIPSSKAAALLAISVSLTYVIYFIHFMA--FNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFF 227
            .||: ..:||.:....:|..:::     ||  ||..:...|..    :..:...:|..|::||..
Zfish   260 LLPV-RMRAAVITGAVLSTIHIV-----MAWRFNLEDSFLYKQ----LCANAMIFLCTNIIGICT 314

  Fly   228 RIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYH 292
            ....:...|.:|.:...:|...|.|::..:|:..||.|:||..:|..::..|..|  :.|..|:.
Zfish   315 HYPAEVSQRQAFKETRGYIQARIHLQRENQQQERLLLSVLPRHVAMEMKADINAK--KEDMMFHK 377

  Fly   293 LGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIK 357
            :          .||.|::||||:||:..:|.|.:..|.::||..|::|:||||..|......|||
Zfish   378 I----------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAWENHCLRIK 432

  Fly   358 FLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAK 422
            .||||||||:||.|...|||...|.:|:.||..|..|.....:|:.||:|:|||.:..||:|..|
Zfish   433 ILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRK 497

  Fly   423 LQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLL 487
            .|:|:|..||.:|:::||.|..|.:|::..||..||. :|.:..|. ...::..|..:.:.|:.:
Zfish   498 WQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLNG-DYEVEAGF-GGDRNAYLNNNNIETFFV 560

  Fly   488 TAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRR 552
            ........::...:.:      :|...:| .|:.|.|           |.:|...|.
Zfish   561 LGCSQKRKEEKAMMAK------MQRARAN-SSEGLMP-----------RWVPDRSFS-------- 599

  Fly   553 ERNLKNEKVERDLGI--------------------------------------------FCVAFK 573
              ..|:.||.|.:||                                            |.:.|:
Zfish   600 --RTKDSKVFRQMGIDEASSKDNRCAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQ 662

  Fly   574 DKSVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIF-YTGVVIN--IIAFFVLTFLLFI 635
            ...:|..|..:.|..|...||....:.|.:::||.|    || :|.:::.  |..|.:|..:|||
Zfish   663 TPLLEKKYSKKVDDRFGGYVACTLLVFCFIVFIQIV----IFPHTPLMLGLFITIFIILAHVLFI 723

  Fly   636 CWYKKVCWWHSGQNEHRSYGKLSCAIFHLF--------EKIQHSFVLRLTVYMMIILCYYMVISL 692
            |                  ...||.  .||        ::|..|.:....|.:..||..::...:
Zfish   724 C------------------AIYSCV--KLFPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFV 768

  Fly   693 ILMSCEKDQY------ELDIIES----KLYNYD---MDPF--------TCFHPWAYTNMMALILG 736
            .:.:|::...      .|:|.||    .|||..   .|||        .|..|..:|..:.|.|.
Zfish   769 NMFTCDRTDMLACVAGHLNISESVTLCLLYNLSGLAEDPFFLCLDQPSACPLPEYFTYSVLLTLL 833

  Fly   737 MSYTFARIPFALKTFIGCAEAVVFVLVVCF-----------------------QYAF----IFEH 774
            ....|..|     :.||....::|: .:||                       .|||    ..:.
Zfish   834 CCSVFLHI-----SSIGKLVLMLFI-QICFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQE 892

  Fly   775 SVTTSPYLKAEIAHSCRVCM--MLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIIL 837
            :||     |..:..|..|.:  .::.:|...:|.|...::::...|....:::..:........|
Zfish   893 TVT-----KVSLRVSIPVILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRL 952

  Fly   838 LNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNF----------QMDLPSLRVLNDII 891
            |:||||..|...:|:...:: ||||::...|:||||.::||          ...:..||:||:||
Zfish   953 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEII 1017

  Fly   892 TAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESS 956
            ..||.::|..| |..:||||.:|.|||||.||:.|..:
Zfish  1018 ADFDEIISEEK-YKQLEKIKTIGSTYMAASGLNDSTYD--------------------------- 1054

  Fly   957 IKE-KNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQP 1020
             || :.|   ...:|.:|:.|...:...|        :.:.:..:::||::.|.::|||:||.:|
Zfish  1055 -KEGRTH---ILALADYAMRLREQMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKP 1107

  Fly  1021 HYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFV 1080
            .||||||.||:||||:|||:...||||.:....||........|||..|||:|::.|||:
Zfish  1108 QYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKGYQLECRGLVKVKGKGDMTTYFL 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AcyC	88..457	CDD:441717	112/373 (30%)
		Nucleotidyl_cyc_III	306..489	CDD:448371	73/182 (40%)
		Nucleotidyl_cyc_III	859..1080	CDD:448371	80/231 (35%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	57/257 (22%)
		Guanylate_cyc	378..562	CDD:425528	74/195 (38%)
		Adcy_cons_dom	590..678	CDD:461877	15/108 (14%)
		Guanylate_cyc	975..1169	CDD:425528	81/233 (35%)