DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	1046	Identity:	274/1046 - (26%)
Similarity:	472/1046 - (45%)	Gaps:	189/1046 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 RWV--MTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAI 179
            :|:  ....|.||....|||.:|:.  .....:|     |.:|.|...|..||:|     .|.||
Zfish   218 KWLHYAGMASWLSQTAQVLGGLAYG--LERDQSW-----YVLFTLFATYTLLPLP-----LLWAI 270

  Fly   180 SV-SLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFH--------YLGFNMMGIFFRIMNDTMV 235
            .. :||.::          |..|:.:.  .|..:..|.        |...|:.|:|...:.|...
Zfish   271 GAGTLTSIL----------HLTAETIR--HISEVGLFRKLLAKALLYTSMNVAGLFIHYLTDRSQ 323

  Fly   236 RSSFLDRYQFITEEIWLR-QARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTA 299
            |.:||:..:.|...:.|. :.:|||.|:| ||||..:|           ::..:|...:......
Zfish   324 RQAFLETRRCIEGRMKLETENQRQERLVL-SILPRFVA-----------LEMISDMTSMDDELDP 376

  Fly   300 ENFMSIQIH--NDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDC 362
            :.|..:.||  .|||||:||:..:|.|:..::.::||::|::|:.|||..|..:...|||.||||
Zfish   377 QQFHKVYIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLNELFGRFDRLAEEYDCLRIKILGDC 441

  Fly   363 YYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDI 427
            ||||:|:.|....||...|.:|::||:.::.:...::.::.||||:|:|::..||:|..|.|:|:
Zfish   442 YYCVSGVPEPQRAHARCCVEMGLAMISTMRSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKWQFDV 506

  Fly   428 WGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPS 492
            |..||.||:.|||.|.||.:|:|..||..|:. .:....| ...:::..|:||.:.|:|:
Zfish   507 WSWDVGIANMLEAGGIPGRIHISRATLDCLDG-SFQTEDG-RGYERNEFLRKHNIDTFLI----- 564

  Fly   493 LDSDKTISIVEGV-PNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNL 556
            ...:..::.:|.. |    :|..:||.        .:.|:...|.    .|...|.|.|...|::
Zfish   565 CHKEDDLNEMEAEHP----KTRHNNRP--------WNKEILASFS----NGSYTQLPTSSACRSM 613

  Fly   557 K---NEKVERDLGI-------------FCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCCLIY 605
            .   |:::|..:.:             ..:.|||..:|..:....|.:||.::...:.:...|:.
Zfish   614 SKEINKRIEHAIDLRSSERMRQEHITPVTLVFKDAHIEEKFSQVRDEMFKTNLVCSFIMLLLLMA 678

  Fly   606 IQSVNNSDIFYTGVVINIIAFFVLTFLLFICW------------YKKVCWWHSGQNEHRSYGKLS 658
            :|::......|...|:. ...|:|.:||.:..            .::.|.|....|..|:
Zfish   679 VQALIPVPRMYLWTVLQ-FCLFLLGYLLLLVMVLAEEFKHSPGVLQQFCCWIHENNSMRN----- 737

  Fly   659 CAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFT-CF 722
                          :|.:|.   |.:.:.|.:..::.....:..|:...|::.|.....|.| |.
Zfish   738 --------------LLTITA---IAMNFGMALFDMMWCNSSEMKEISTRETEGYKAGQKPLTACT 785

  Fly   723 HPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHS-----VTTSPYL 782
            :|..:.....:.:.....|.|:...||..|......|:...:...:..::.|.     ::.|.:|
Zfish   786 YPEVFVLSGVVSMVTCAVFLRMSSLLKLTILLFVVAVYTYFIEVSFHMLYVHQQEHEHLSRSHFL 850

  Fly   783 KAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNK-QKSADVTNQSIIILLNNILPSHV 846
            :.:......:.|.:|.:....|:.|..|::::...|..|.: |:..|:...: ..||:||||:||
Zfish   851 RRKGVSILLMAMFMIAVLYNGRRWEATTRLDFLWRLQAQQEVQEMRDLREHN-ECLLHNILPAHV 914

  Fly   847 VEVYLS-SIAKHELYYENYRMVSVMFAMLTNF-----QMDL-----PSLRVLNDIITAFDRLLSA 900
            ...:|. :....|||.::|..|.||||.:..|     |.::     ..|::||:||..||.||.
Zfish   915 ARHFLERNRNDQELYSQSYDEVGVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELLE- 978

  Fly   901 YKQYYV-VEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNH-D 963
             :.|:: :||||.:|..||||.||.                      ...:||:   :.:.:| .
Zfish   979 -ESYFLDIEKIKTIGSCYMAASGLS----------------------PDKQSRV---VNDWHHLS 1017

  Fly   964 EVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNP 1028
            |    :..|||.:...|...||        .:::..::|:||:.|.::|||:||::|.|||||..
Zfish  1018 E----LVLFALAMQETLREINK--------HSMNNFQLRVGIAHGPVVAGVIGATKPQYDIWGMT 1070

  Fly  1029 VNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKG----RGEIPTYFVGIDKDLKFM 1089
            ||:||||:|||:||.|||.:.|...|.::..:...||..::||    :|.:.|||:...:.|...
Zfish  1071 VNLASRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFISTKRRLVSS 1135

  Fly  1090 SKKIDR 1095
            :...||
Zfish  1136 NGIADR 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	46/185 (25%)
		CYCc	262..464	CDD:214485	74/203 (36%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	72/184 (39%)
		CYCc	831..1055	CDD:214485	81/236 (34%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	79/236 (33%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831	46/197 (23%)
		CYCc	343..538	CDD:214485	78/206 (38%)
		Guanylate_cyc	382..564	CDD:278633	71/183 (39%)
		DUF1053	<611..661	CDD:283888	8/49 (16%)
		CYCc	899..1097	CDD:214485	81/237 (34%)
		Guanylate_cyc	928..1126	CDD:278633	79/236 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810