Protein Alignment ACXA and adcy2b

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1136
• Identity: 309/1136 - (27%)
• Similarity: 511/1136 - (44%)
• Gaps: 227/1136 - (19%)

  Fly    44 EEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINF 108
            ||:|.: |..:.::|.:|:.:.||:.:.        :.:.|.:.:.::...|.|:.: |.|.: |
Zfish   120 EEHMAF-IMTVPTTLAIFLAIFILVCIE--------SVFKKLLRLFSLLIWGCLVAM-GYLFM-F 173

  Fly   109 FEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKA 173
            |...:.....|..|                                 :|::.::|..||. |.:.
Zfish   174 FGGIICPWDQVSFF---------------------------------LFIVFVVYTMLPF-SMRD 204

  Fly   174 AALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGL--DIVSIDFFHYLGFNMMGIFFRIMNDTMVR 236
            |.:.::..|.::.:    .::....|.:.::..|  .|:: :...::..|:.|.:.:.:.|..::
Zfish   205 AVIASVLTSSSHTL----VLSICLSNTSDHMEALVWQILA-NIIIFICGNVAGAYHKHLMDLALK 264

  Fly   237 SSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPD-------NDFYHLG 294
            .::.|....|...|.|...:.|:..||.|:||..||:.::..|.:::..|:       |:|::|
Zfish   265 QTYHDTCNCIKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEIIQRLKGPNFSQAENTNNFHNL- 328

  Fly   295 TSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFL 359
                     .:|.|.:|||||||:|.:|:|.:..:..:||.:|::|:.:||..|......|||.|
Zfish   329 ---------YVQRHTNVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKIL 384

  Fly   360 GDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQ 424
            |||||||:||.:...|||...|.:|:.|...|::|.....::|.||:|||||.:..||||..|.|
Zfish   385 GDCYYCVSGLPDPLLDHAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQ 449

  Fly   425 YDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTA 489
            ||:|..||.:|:.:||.|.||.||:|..||..||. .|.:..| ....:|..|::|.:.|||:..
Zfish   450 YDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG-AYKVEQG-NGQSRDSYLKEHGIVTYLVIN 512

  Fly   490 IPSLDSDKTISIVEGVPNL-DLQTVGSNRKSQIL------KPNLLSH---EMREE-----FRKMP 539
             |..:....:.:....|.: ..:...|.|.:|.|      ||....|   .|..|     .|.:|
Zfish   513 -PKAEKRSPLLLSAIRPTMYGAKMRASVRMTQYLESWGAAKPFANLHHRDSMTNENGMINTRDVP 576

  Fly   540 VGGFKFQFPWSRRERN----------------------------LKNEKVERDLGIFCVAFKDKS 576
            :|.:..|   .|.||.                            ||:|.::| :.:|   |.:|:
Zfish   577 LGQYNCQ---QRSERTKSQKKRFEEELNERIIRTIDGINSQKQWLKSEDIQR-ISLF---FHNKA 634

  Fly   577 VEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINI---IAFFVLTFLLFICWY 638
            :|..|.......|||.|.....|..|:..:|.:    :.....|:.:   :||.:|..:|.||:.
Zfish   635 LEKEYRATTLPAFKYYVTCACLIFFCIFIVQVL----VLPKTTVLEVSFGMAFLLLALILCICFA 695

  Fly   639 KKVCWWHSGQNEHRSYGK-LSCAIFHLFEK---------IQHSFVLRLTVYMMIILCYYMVI--- 690
            ..:..|          || .||.:..|...         |:.:..:..|..::::..:.|..
Zfish   696 GHILQW----------GKAASCTMPRLPSSSKVITNKPWIRLALTMATTALILVMAVFNMFFLGE 750

  Fly   691 -------SLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFAL 748
                   ||.:.:...|.....|..|....:.:..|      .|:.::.||  ....|.||.:.|
Zfish   751 DRMVASTSLNISNSSMDGPYGQITNSSNNKFYLPYF------IYSCILGLI--SCSVFLRINYEL 807

  Fly   749 KTFIGCAEAVVFVLVVCFQYAFIF-EHSV----TTSP----YLK-AEIAHSCRVCMMLITMYAKE 803
            |..|.....|.:.:::...:|.|. ::|:    |..|    .|| .:...|..:.:..:|:....
Zfish   808 KMIIMLGAVVAYNIIILQTHASILDDYSMALYKTQQPDRPGVLKDLKTMGSISLFIFFVTLLVLA 872

  Fly   804 RQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHE-LYYENYRMV 867
            ||:|:..::::......:.:.:..:.......:||.|:||:||.|.:|....|:| ||:::|..|
Zfish   873 RQNEYYCRLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLGRNWKNEDLYHQSYDTV 937

  Fly   868 SVMFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACG 922
            .||||.:.:|          :..|..||:||:||..||.|||..| :..|||||.:|.|||||.|
Zfish   938 CVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGSTYMAATG 1001

  Fly   923 LDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAF---IMATFALDLMRVLSVCN 984
            |:                        |...||.:   :.||....   .|..||..|:..|.|.|
Zfish  1002 LN------------------------VTPGLEYA---QYHDRQYMHIGTMVEFAFALVGKLDVIN 1039

  Fly   985 KAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKE 1049
            |        .:.:...:|:||:.|.::|||:||.:|.||||||.||:||||||||:.|.||||:|
Zfish  1040 K--------HSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEE 1096

  Fly  1050 TAQTLEEFDVMCYYRGLTFVKGRGEIPTYFV 1080
            |...|:....||..||:..|||:|::.|:||
Zfish  1097 TNWILQTLGYMCSCRGIINVKGKGDLRTFFV 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	45/255 (18%)
		CYCc	262..464	CDD:214485	85/208 (41%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	80/182 (44%)
		CYCc	831..1055	CDD:214485	92/237 (39%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	91/233 (39%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831	42/236 (18%)
		CYCc	283..486	CDD:214485	85/213 (40%)
		Guanylate_cyc	328..512	CDD:278633	81/195 (42%)
		DUF1053	542..646	CDD:283888	23/110 (21%)
		CYCc	899..1106	CDD:214485	93/242 (38%)
		Guanylate_cyc	929..1128	CDD:278633	93/235 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880