Protein Alignment ACXA and gucy1b2

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: XP_685297.5
• Gene: gucy1b2 / 557191
• ZFINID: ZDB-GENE-130530-664
• Length: 757
• Species: Danio rerio
• Alignment Length: 870
• Identity: 170/870 - (19%)
• Similarity: 287/870 - (32%)
• Gaps: 323/870 - (37%)

  Fly   300 ENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYY 364
            |.||:.:|::|:             .|...|::..|:|.          :|.:|. :|..|:.::
Zfish    33 ETFMTYEIYDDI-------------ITLRLVQEACKMLD----------VSSEVV-LKLFGEYFF 73

  Fly   365 CVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWG 429
            ....:...|    ||..:||.:::..|:.:.           .:||         ...|.|:...
Zfish    74 SFCKMSGYD----TMLRTLGGNLVEFIENLD-----------ALHS---------YLALSYEAMN 114

  Fly   430 ADVNIASRLEATGSPGYVHVSGRTLSSLNAEE---YNIYPG-TESAQKDPVLQKHPMSTYLLTAI 490
            |......|::          .||.|....::.   |:|.|| .|:..||
Zfish   115 APSFRVERMD----------DGRILLHYYSDRKGLYHIVPGIIEAVAKD---------------- 153

  Fly   491 PSLDSDKTISIV----------------------EGVPNLDLQTVGSNRKSQILKPNLLSHEMRE 533
             ..||:.|::|:                      |.|.....||..:|.:.:||:   :..:..|
Zfish   154 -FFDSEVTMTILNQSEEDERTGKKEHVVFHMVQKEKVTKRKAQTRQNNSEEEILE---VKKDKEE 214

  Fly   534 EFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWG 598
            ..|:|           ..|..||:          .|   ..|...|.       :.:..|.||.|
Zfish   215 TMRRM-----------KARYANLQ----------LC---PRKRSPWE-------LVRSIVMLGQG 248

  Fly   599 IGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNEHRSYGKLSCAIFH 663
                                   |:...|..:       |.|..|     .|.:::    |..|.
Zfish   249 -----------------------NLRQSFTPS-------YPKTLW-----IEEQAF----CNAFP 274

  Fly   664 LFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLYNYDMDPFTCFHPWAYT 728
            .........|::.|.    :.....|..|.......|:|                ||..||....
Zfish   275 FHIVFDSDLVVKHTG----VNIQKFVPGLQTAGIRLDEY----------------FTIVHPEVIF 319

  Fly   729 NMMALILGMSYTFARIPFALKT-------------------FIGCAEAVVFVLVVC--------- 765
            |:.::     ..|....|.|||                   .:...|::..::.:|
Zfish   320 NIQSI-----KKFINSQFVLKTRREMLPEVQQNQPTLKLRGQMMWMESLNCMIYLCSPKLRSLQE 379

  Fly   766 -----FQYAFIFEHSVTTSPYL-----KAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDL 820
                 ...|.|.:|..|....|     .|||..|.::          ||:.|....::..|.::.
Zfish   380 LEERGLHLADIAQHDTTRDLILLNQQRLAEIELSNQL----------ERKKEELRILSRNLEIEK 434

  Fly   821 QNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQ------M 879
            |..:|           ||..:||:||.. .|....:.|.  ..:::.:::|:.:..|.      .
Zfish   435 QKSEK-----------LLYAMLPTHVAN-QLKEGKRVEA--GEFKVCTILFSDVVTFTNICAACE 485

  Fly   880 DLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSS 944
            .:..:.:||.:.:.||||.|.:..|    |::.:|..||...|:
Zfish   486 PIQIVNMLNAMYSRFDRLTSIHNVY----KVETIGDAYMVVGGV--------------------- 525

  Fly   945 ELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQ 1009
                       .:....|.|   .:|.|||.:............|:|.       :||:|:.||.
Zfish   526 -----------PVPTNTHAE---RVANFALGMRIAAREVTNPITGQPI-------QIRVGLHTGP 569

  Fly  1010 IMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEE---FDVMCYYRGLTFVKG 1071
            ::|||||...|.|.::|:.||.||||||.|:..||.|:..|...:::   |::.  .||...|||
Zfish   570 VLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFEMA--ERGEIEVKG 632

  Fly  1072 RGEIPTYFVGIDKDLKFMSKKIDRL 1096
            :|.:.|||:     ||.:.|..:::
Zfish   633 KGLMRTYFL-----LKNLQKSDEQI 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485	29/166 (17%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	32/186 (17%)
		CYCc	831..1055	CDD:214485	57/229 (25%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	58/229 (25%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	38/204 (19%)
		CAF-1_p150	<166..277	CDD:288454	28/183 (15%)
		HNOBA	269..453	CDD:285003	41/234 (18%)
		CYCc	432..618	CDD:214485	59/245 (24%)
		Guanylate_cyc	459..642	CDD:278633	60/237 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810