Protein Alignment ACXA and adcy1a

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_001161821.1
• Gene: adcy1a / 557026
• ZFINID: ZDB-GENE-070705-302
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1208
• Identity: 298/1208 - (24%)
• Similarity: 514/1208 - (42%)
• Gaps: 317/1208 - (26%)

  Fly    12 RERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVI- 75
            |.|..|| |....||.::       |||  ||..:.||.::|..::....:.:|||...||.::
Zfish    17 RRRKSRC-LAGACERDFD-------CKE--LETLFQKYNLKLEQTATLKALAILILAASALALVE 71

  Fly    76 -IWSFTEYT----------------------KYIYINAIFDLGSLILVTGLLSINFFEDFVIRHR 117
             :.:.:.:|                      ||:.:..:..:..|.|:
Zfish    72 LLSAGSRFTVSKGSHPVHCVIFTSLFIVTNVKYLQVTQLQQIARLALL----------------- 119

  Fly   118 WVMTFTSTLSAYVVVLGDIAFNTY-YYYKSNWPLNTLYDVFVLCMI-YMFLPIPSSKAAALLAIS 180
            :..||......:.:.||.....|: ....|..|...::.:.::..: |..||: .:..|.|..:.
Zfish   120 FSFTFALLCCPFPLALGHGTQGTHGPDAPSTTPEQGVWQLMLVTFVAYSLLPV-RTLLAVLFGVL 183

  Fly   181 VSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQF 245
            |:.:      ||:.......|:.......:..:....:|.|:.|:|.|:..:...|.:||.....
Zfish   184 VAAS------HFIVTATSVTARRPRVWTPLVANAVLLVGVNLSGVFVRVRTERAQRKAFLQARNC 242

  Fly   246 ITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHND 310
            |.:.:.|.....::..||.|:||..:|    ..:||..::|....:|.         :.||.|::
Zfish   243 IQQRLQLEDENEKQERLLMSLLPRNVA----MEMKEDFLKPPERIFHK---------IYIQRHDN 294

  Fly   311 VSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPD 375
            ||||:||:|.:|.|.:..|.::|||:|::|:.:||..|.....:|||.||||||||:||.:...|
Zfish   295 VSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKAD 359

  Fly   376 HATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEA 440
            ||...|.:|:.||..|..|:....:::.||:|:|:|.:..||:|..|.|||:|..||.:|:.:||
Zfish   360 HAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEA 424

  Fly   441 TGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPS----LDSDKTISI 501
            .|.||.||::..||..||. :|.:.||. ..::...|.||.:.|:.:  :||    :.....:|.
Zfish   425 GGLPGKVHITKATLECLNG-DYEVEPGF-GHERHAFLSKHAIETFFI--VPSHRRKIFPGLILSD 485

  Fly   502 VEGVPNLDLQTV----------GSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQ---------- 546
            ::....::.:||          ....|::|...|:::.|..::.|.:.....|.:
Zfish   486 IKPAKRMEFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRTSFSAGMV 550

  Fly   547 --FPWSRRERNL-------KNEKVERDLGIFCVAFKDKSVEWNYLHQPDYIFKYSVALGWGIGCC 602
              .|.:|..|.:       :.|....||....:.::.:..|..||...|
Zfish   551 QNSPGTRVNRYIGRLIEARQTESEMADLNYITLTYRSREREQRYLQVYD---------------- 599

  Fly   603 LIYIQSVNNSDIFYTGVVINII--AFFVLTFLLFICWYKKVCWWHSGQNEHRSYGKL------SC 659
                      |.|.:.|||:::  :||.:.:.|.|                 ..|.|      .|
Zfish   600 ----------DAFISAVVISLVLTSFFAVVYFLII-----------------PQGLLVVILLVLC 637

  Fly   660 AIFHLFEKIQHSFVLR-------LTVYMMIILCYYMVISL--ILMSCEKDQYELDIIESKLYNYD 715
            ..||: ..:.:..|..       ||:.:..:||.::|:.:  :...|
Zfish   638 LCFHM-ASVMYLHVTHVQCSPDCLTLQIRTVLCGFLVLLMYSVTQGC------------------ 683

  Fly   716 MDPFTCFHPWAY-----TNMMALI----LGMSYTFAR-IPFALKTFIGCAEA------------- 757
              ..||. ||:.     .:|:.::    .|:.|...: .|:   .|:.|..|
Zfish   684 --VVTCV-PWSLEGNSSISMVTVVTVNGTGVGYRVCKYTPY---VFLSCVMASLSVALYLRVSSL 742

  Fly   758 --VVFVLVVCFQYAFIFEHSVTTSPYLKAE-----------------------IAHSCR---VCM 794
              ::.:|::...:..:.|    ||.|.||.                       :.| ||   :.:
Zfish   743 PKILLLLLLNILHTVVME----TSGYRKAVGGGFFHTHGYDPVLAMLLFSGALVLH-CRQLDLKL 802

  Fly   795 MLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKH-E 858
            .|..::|.:.:.|.:.....||:    ||:            :|.|:||:||.:.:|.|..:: :
Zfish   803 RLDYLWATQAEEERDDMERVKLD----NKR------------ILFNLLPAHVAQHFLLSNPRNMD 851

  Fly   859 LYYENYRMVSVMFAMLTNF----------QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVV 913
            |||::|..|.|:||.:.||          .|.:..||:||:||..||.|:.. :.|..:||||.:
Zfish   852 LYYQSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDALMDK-ECYRDIEKIKTI 915

  Fly   914 GCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMR 978
            |.|||||.||                  :.:|..:|:..:.:.:         ..:|.:|:::..
Zfish   916 GSTYMAAVGL------------------VPTEGSKVKKSISAHL---------CTVADYAIEMFD 953

  Fly   979 VLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGH 1043
            ||...|.        ::.:...:|:||:.|.::|||:||.:|.||||||.||:||||:|||:.|.
Zfish   954 VLDAINY--------QSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGK 1010

  Fly  1044 IQVTKETAQTLE-EFDVMCYYRGLTFVKGRGEIPTYFV 1080
            ||||::..:.|. .:|..|  ||...|||:|::.|||:
Zfish  1011 IQVTEDVFRLLSGYYDFNC--RGQVSVKGKGQMLTYFL 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	50/274 (18%)
		CYCc	262..464	CDD:214485	81/201 (40%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	76/182 (42%)
		CYCc	831..1055	CDD:214485	78/234 (33%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	81/231 (35%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831	28/141 (20%)
		CYCc	251..446	CDD:214485	80/208 (38%)
		Guanylate_cyc	287..469	CDD:278633	77/183 (42%)
		DUF1053	513..601	CDD:283888	15/113 (13%)
		CYCc	819..1029	CDD:214485	84/261 (32%)
		Guanylate_cyc	852..1048	CDD:278633	82/233 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810