DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and gucy1a1

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001296458.1	Gene:	gucy1a1 / 550420	ZFINID:	ZDB-GENE-050417-230	Length:	679	Species:	Danio rerio

Alignment Length:	224	Identity:	61/224 - (27%)
Similarity:	108/224 - (48%)	Gaps:	35/224 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 LRQARRQESLLLDSILPPQIAK------PIQKSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHND 310
            |.:.:|:...||.:|.|..:|:      |:|                      |:.|      :.
Zfish   447 LEEEKRRTVELLFTIFPGNVAQRLWQGLPVQ----------------------AKKF------DH 483

  Fly   311 VSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPD 375
            |::|::|:|.:|.:.:..|..::|.:|.:||.|||.......|.:::.:||.|....||.:..|.
Zfish   484 VTVLFSDIVGFTAICSRCTPMQVVNMLSELYTRFDHHCGELDVYKVETIGDAYCVAGGLHKESPT 548

  Fly   376 HATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEA 440
            ||.....:.:.|:....||:......|.||||:|||::.|||:|....:|.::|.:|.:|::.|:
Zfish   549 HAVQIALMALKMMELSDEVTTPMGEVIRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFES 613

  Fly   441 TGSPGYVHVSGRTLSSL-NAEEYNIYPGT 468
            ...|..::||..|...| :..|:.:.|.|
Zfish   614 CSLPRKINVSPTTYRLLKDCPEFTLIPRT 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	9/44 (20%)
		CYCc	262..464	CDD:214485	57/208 (27%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	50/164 (30%)
		CYCc	831..1055	CDD:214485
		Nucleotidyl_cyc_III	859..1080	CDD:299850
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	7/22 (32%)
		CYCc	449..635	CDD:214485	57/213 (27%)
		Guanylate_cyc	476..647	CDD:278633	53/195 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810