DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and ACXB

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster

Alignment Length:	1112	Identity:	757/1112 - (68%)
Similarity:	905/1112 - (81%)	Gaps:	29/1112 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNKKNTYKTPYRERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPML 65
            |.||..|..      |:|.|:||:|||||:.||||:||||.|||||.||:||||||.||||.|:.
  Fly     1 MYKKTAYAP------RKCYLDYTDERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLF 59

  Fly    66 ILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYV 130
            |.::|..::..|.|:|..|.||..::..:..|:.|.|:|||||||.||:||||:|.|:|.||||:
  Fly    60 IFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLRHRWIMVFSSILSAYI 124

  Fly   131 VVLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAF 195
            |||.||.....:::|.:|||||||||||||||||||||||.:.|||||.||||.|:..||:|:..
  Fly   125 VVLVDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKS 189

  Fly   196 NEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQES 260
            ::.::::.||.||.:.:|.|||||||:||||||||||||||||||||:||:.||:||||||:|||
  Fly   190 DDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQES 254

  Fly   261 LLLDSILPPQIAKPIQKSIKEKII--QPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQ 323
            :|||||||||||||||:||||:|:  :.|:|...:...|| ||||:||||.||||||||:||||.
  Fly   255 MLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRT-ENFMAIQIHPDVSILYADVVNYTH 318

  Fly   324 LTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMI 388
            ||||||||||||||||||.|||:||.:|||||||||||||||||||||:|||||.||||||||||
  Fly   319 LTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMI 383

  Fly   389 ANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRT 453
            |||:||..:|:|:|.||||||||||.|||||:|||||||||.||:||:||||||.||||||||||
  Fly   384 ANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRT 448

  Fly   454 LSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRK 518
            |||||..||.::||||.||.||:|||.||:||||||.||.:|.:::..|.....:|:..:|::||
  Fly   449 LSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRK 513

  Fly   519 SQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSVEWNYLH 583
            |.||:|.|:|.|:||||:|||||||..:.|..|...|  :|||...||:|||||||.|:||:|||
  Fly   514 SPILRPTLMSDELREEFKKMPVGGFNIRSPCCRDNSN--DEKVNHGLGMFCVAFKDSSLEWSYLH 576

  Fly   584 QPDYIFKYSVALGWGIGCCLIYIQSVNNS-DIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSG 647
            :||:|.||||.|.|||||||||||.||:. .|....:||:::.|..||.||||.|:||||||...
  Fly   577 KPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCV 641

  Fly   648 QNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDIIESKLY 712
            :|:.|.||::||.:|.::|:||||||||:|:||.|:..||::||.||::|:|:|||||:|.||||
  Fly   642 ENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLY 706

  Fly   713 NYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIFEHSVT 777
            :||:....||:||.:|:|::||:|:||||||||||||..|.|...|.::::|.|||:||||||.|
  Fly   707 HYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSAT 771

  Fly   778 TSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIILLNNIL 842
            |:|::|||:||..||||||:||||||||||||||:|:|:|.|||.|||:||:||:||||||.|||
  Fly   772 TTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNIL 836

  Fly   843 PSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYYVV 907
            |||||||||.|:|.||||||||:|||||||||.|||||||||||||||||.|||||:|||:||||
  Fly   837 PSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQMDLPSLRVLNDIITEFDRLLNAYKEYYVV 901

  Fly   908 EKIKVVGCTYMAACGLDFSLIENLDSNSNFGS---TSLSSELEQVRSRLESSIKEKNHDEVAFIM 969
            ||||||||||||||||||:|     :.|.|||   .|.|||||||..|.||...|.:||||||||
  Fly   902 EKIKVVGCTYMAACGLDFTL-----AKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIM 961

  Fly   970 ATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASR 1034
            .|||||||||||||||||||.|||||||||||.||||||:|||||||||||||||||||||||||
  Fly   962 TTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASR 1026

  Fly  1035 MESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFVGIDKDLKF---------MS 1090
            ||||||.|||.||:|||..||:||:||.|||:|||||||||||||||||.:|||         ||
  Fly  1027 MESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGIDDNLKFLPSNVKKNNMS 1091

  Fly  1091 KKIDRLS 1097
            |:...||
  Fly  1092 KRFSILS 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	158/250 (63%)
		CYCc	262..464	CDD:214485	162/203 (80%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	150/182 (82%)
		CYCc	831..1055	CDD:214485	185/226 (82%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	183/223 (82%)
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	154/239 (64%)
		CYCc	249..459	CDD:214485	167/210 (80%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	152/185 (82%)
		CYCc	825..1047	CDD:214485	185/226 (82%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	183/223 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449932
Domainoid	1	1.000	187	1.000	Domainoid score	I6943
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27505
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.860