DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXA and Adcy1

DIOPT Version :9

Sequence 1:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_033752.1 Gene:Adcy1 / 432530 MGIID:99677 Length:1118 Species:Mus musculus


Alignment Length:1186 Identity:305/1186 - (25%)
Similarity:497/1186 - (41%) Gaps:278/1186 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRL----MISSLTVFV---------- 62
            |..||.|..|:.             |.|  ||..:..|.:||    .:.:|.|..          
Mouse    29 RRGFRACGEEFA-------------CPE--LEALFRGYTLRLEQAATLKALAVLSLLAGALALAE 78

  Fly    63 ----------------PMLILLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFED 111
                            |:..:|.:||.|:     ...:.:.::.:..:|.|.|        ||  
Mouse    79 LLGAPGPAPGLAKGSHPVHCILFLALFVV-----TNVRSLQVSQLQQVGQLAL--------FF-- 128

  Fly   112 FVIRHRWVMTFTSTLSAYVVVLGDI-------AFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIP 169
                     :.|..|......||..       |..:....:..|.|     :.|..:.|..||:.
Mouse   129 ---------SLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQL-----LLVTFVSYALLPVR 179

  Fly   170 SSKAAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTM 234
            |     ||||...|  |:...|.:.......||.......:..:...:.|.||.|:|.||:.:..
Mouse   180 S-----LLAIGFGL--VVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERS 237

  Fly   235 VRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQKSIKEKIIQPDNDFYHLGTSRTA 299
            .|.:||.....|.:.:.|.....::..||.|:||..:|    ..:||..::|....:|.      
Mouse   238 QRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVA----MEMKEDFLKPPERIFHK------ 292

  Fly   300 ENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYY 364
               :.||.|::||||:||:|.:|.|.:..|.::|||:|::|:.:||..|.....:|||.||||||
Mouse   293 ---IYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYY 354

  Fly   365 CVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWG 429
            ||:||.:...|||...|.:|:.||..|..|:....:::.||:|:|:|.:..||:|..|.|||:|.
Mouse   355 CVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS 419

  Fly   430 ADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTAIPS-- 492
            .||.:|:.:||.|.||.||::..||:.||. :|.:.|| ...:::..|:.|.:.|:.:  :||  
Mouse   420 NDVTLANVMEAAGLPGKVHITKTTLACLNG-DYEVEPG-HGHERNTFLRTHNIETFFI--VPSHR 480

  Fly   493 --LDSDKTISIVEGVPNLDLQTV----------GSNRKSQILKPNLLSHEMREEFRKMPVGGFK- 544
              :.....:|.::....:..:||          ....|::|...|:::.|..::.|.:.....| 
Mouse   481 RKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKL 545

  Fly   545 -----------FQFPWSRRERNL-------KNEKVERDLGIFCVAFKDKSVEWNYLHQPDYIFKY 591
                       :..|.:|..|.:       :.|....||..|.:.:|....|..|....|..|..
Mouse   546 RNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTS 610

  Fly   592 SVALGWGIGCC--LIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVCWWHSGQNEHRSY 654
            :|.|...:...  |||:..:..|      |.:.::..|.:.||                      
Mouse   611 AVVLALILAALFGLIYLLVIPQS------VAVLLLLVFSICFL---------------------- 647

  Fly   655 GKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISL--ILMSCEKDQYELDIIESKLYNYDMD 717
              ::|.::....::| .|...||:.:...||.::|:.:  :...|                    
Mouse   648 --VACTLYLHITRVQ-CFPGCLTIQIRTALCVFIVVLIYSVAQGC-------------------- 689

  Fly   718 PFTCFHPWAY---TNMMALIL---GMSYTFARIP------FALKTFIGCAEAVVFVLVVCFQYAF 770
            ...|. |||:   :|...::|   |.......:|      ..|...:|.....:|:.|.... ..
Mouse   690 VVGCL-PWAWSSQSNSSLVVLAAGGRRTVLPALPCESAHHALLCCLVGTLPLAIFLRVSSLP-KM 752

  Fly   771 IFEHSVTTSPYLKAEIAHSCRV----------------CMMLITMYAKERQSEFNTKMNYKLNLD 819
            |....:|||..|..|::...:|                .:...|:....||.:...:::|.....
Mouse   753 ILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQ 817

  Fly   820 LQNKQKSAD---VTNQSIIILLNNILPSHVVEVYLSSIAKH-ELYYENYRMVSVMFAMLTNF--- 877
            .:.::...:   :.|:.|:.   |:||:||.:.:|.|..:: :|||::|..|.||||.:.||   
Mouse   818 AEEERDDMERVKLDNKRILF---NLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDF 879

  Fly   878 -------QMDLPSLRVLNDIITAFDRLLSAYKQYYV-VEKIKVVGCTYMAACGLDFSLIENLDSN 934
                   .|.:..||:||:||..||.|:.  |.:|. :||||.:|.|||||.||       ..:.
Mouse   880 YIELDGNNMGVECLRLLNEIIADFDELMD--KDFYKDLEKIKTIGSTYMAAVGL-------APTA 935

  Fly   935 SNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTG 999
            ......|:||.|                    ..:|.||:|:..||...|.        ::.:..
Mouse   936 GTRAKKSISSHL--------------------CTLADFAIDMFDVLDEINY--------QSYNDF 972

  Fly  1000 EIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYR 1064
            .:|:||:.|.::|||:||.:|.||||||.||:||||:|||:.|.||||:|..:.|:........|
Mouse   973 VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRCSYQFVCR 1037

  Fly  1065 GLTFVKGRGEIPTYFV 1080
            |...|||:||:.|||:
Mouse  1038 GKVSVKGKGEMLTYFL 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXANP_620475.2 AC_N <42..291 CDD:292831 59/285 (21%)
CYCc 262..464 CDD:214485 81/201 (40%)
Nucleotidyl_cyc_III 306..489 CDD:299850 75/182 (41%)
CYCc 831..1055 CDD:214485 86/235 (37%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 87/231 (38%)
Adcy1NP_033752.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
AC_N <158..291 CDD:292831 37/148 (25%)
CYCc 257..452 CDD:214485 80/208 (38%)
Guanylate_cyc 293..475 CDD:278633 76/183 (42%)
Interaction with calmodulin. /evidence=ECO:0000250 492..519 2/26 (8%)
CYCc 825..1036 CDD:214485 87/250 (35%)
Guanylate_cyc 858..1055 CDD:278633 88/233 (38%)
Interaction with calmodulin. /evidence=ECO:0000250 1023..1046 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1079..1118
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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