DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and CG32301

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_728724.2	Gene:	CG32301 / 38285	FlyBaseID:	FBgn0052301	Length:	1111	Species:	Drosophila melanogaster

Alignment Length:	1129	Identity:	365/1129 - (32%)
Similarity:	586/1129 - (51%)	Gaps:	107/1129 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 WEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLILLIVALQVIIWSFTEYTKYIYINAIF 92
            :|...|:.:|:||.||..|.::...:.::.:|..:.::.:|::...::::|..:...::.:...|
  Fly    21 YEWKLLRYKCRELRLEGVYHRHCHLVSVALVTQLIIVIEILMLIHVILLFSVVKNIDFLTVLPYF 85

  Fly    93 DLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVVVLGDIAFNTYYYYKSNWPLNTLYDVF 157
               :::|:|..:.:...|..|.::..:....|.|.|.::...|:.....|:  ..:.|...||..
  Fly    86 ---AVMLLTPSILMPSREPNVEQYESIAILVSCLMALLLTAMDLILPICYF--RPFSLVPSYDHV 145

  Fly   158 VLCMIYMFLPIPSSK--AAALLAISVSLTYVIYFIHFMAFNEHNVAKYVHGLDIVS-ID------ 213
            |:.:||:..||...|  .|..|.::|||    ::..:||.           :|.:| :|
  Fly   146 VIVLIYLMFPIAFVKNGRAYFLGLAVSL----FYFGYMAL-----------IDKISTLDKVWELT 195

  Fly   214 -FFHYLGF-NMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESLLLDSILPPQIAKPIQ 276
             :..||.| ||:.:|.....:..:||..|.|||.:.:.:..:.|.::|..|||||:|..:|:.:|
  Fly   196 AYGAYLFFLNMLCMFLSRFQEYNMRSGILSRYQVVYQNLVFQMAMKEEKALLDSIIPVTLARSLQ 260

  Fly   277 KSIKEKIIQPDNDFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQLTTTLTVEKLVKVLHDLY 341
            .:|...|.:..::.  :..::|...||  :.|.:||||.||:|::|.||||:.|..||.:||:|:
  Fly   261 DAIASHIEEDPSNL--MPFTKTRHLFM--EPHPEVSILEADMVDFTGLTTTMEVSDLVAILHELF 321

  Fly   342 ARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRI 406
            ..|||||...:..|||||||.|.||.|:....|.||...|:..:.||...:|||..|:..|.:||
  Fly   322 VSFDLAANHNRATRIKFLGDSYTCVTGIPSYFPTHANACVNQALDMIEISREVSKRRNKKIDLRI 386

  Fly   407 GVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNIYPGTESA 471
            |||||.:.||:||..|.|:|||..||:|.:|||::|.||.||:|.|||..|: ..|....||::|
  Fly   387 GVHSGEILAGIIGLTKWQFDIWSKDVDITNRLESSGLPGMVHISSRTLGLLD-NHYVYEEGTDTA 450

  Fly   472 QKDPVLQKHPMSTYLL-TAIPSLD------------SDKTISIVEGVPNLDLQTVGSNRKSQILK 523
            :.||:||:..:||||: :.:|:.:            :|...|........|:|.     |:|
  Fly   451 KLDPLLQRSNLSTYLIRSRLPNFEDTDDLEDDNFSLNDYRFSFSFSQDYEDIQV-----KAQ--- 507

  Fly   524 PNLLSHEMREEFRKMPVGGF---KFQFPWSRRERNLKNEKVERDLGIFCV--AFKDKSVEWNYLH 583
                 .:|..|...|||...   |.:.|..|..:...||:....|..:.:  .|:...:||::..
  Fly   508 -----RDMILEVEHMPVNRVQTCKIRRPMHRIAKEDINEEYRFHLESYYLFTTFRSWRMEWSFNK 567

  Fly   584 QPDYIFKYSVALGWGIGCCLIYIQSVNNSDIF-YTGVVINIIAFFVLTFL-LFICWYKKVCWWHS 646
            ..|.:.|||:.:....|..:|.:..:..|:.. ||    .:.:.|:|..| |.:..|||:  |..
  Fly   568 MRDLLMKYSLGMMVFAGATIIAMDLLVKSEAMDYT----MLFSLFLLILLPLLLASYKKL--WLR 626

  Fly   647 GQNEHRSYGKLSCAIFHL---FEK----IQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYEL 704
            |    |....::...|.|   |.|    |:.|..:|:.:.:|::...|::.|..:.||:..:.||
  Fly   627 G----RRLSPITQPTFFLSRWFIKASDLIEKSVFVRIPLAIMVLFLLYVMSSETVFSCDIARLEL 687

  Fly   705 DIIESKLYNYDMDP-FTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQY 768
            :||.|:|:|  :.| ..||.||..|..:.::|.:......||..:|..:|.|.....|:.|...|
  Fly   688 EIINSELHN--LRPQMLCFMPWGVTYAVVIVLSLMLVIIGIPLIIKLGVGLAILGSHVITVHAYY 750

  Fly   769 AFIFEHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQS 833
            .|.||.|.||:..:.:.:|||..:....|.:..:|....:..|.:|.:::..:.|.:...|..::
  Fly   751 GFAFERSQTTNIGVTSSLAHSWYMVAFFIVVVVREGYLNYILKASYFMSMCFEKKHELTKVKTRT 815

  Fly   834 IIILLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLL 898
            |.|::.||||:||.||:.......:|||||:..|:||||.:.|::.|...||.|:::|..||.||
  Fly   816 IKIIMANILPTHVAEVFKVRRRSDQLYYENFSQVAVMFATIENYEADKSGLRALHEMICYFDELL 880

  Fly   899 SAYKQYYVVEKIKVVGCTYMAACGL------DFSLIENLDSNSNFGSTSLSSELE---------Q 948
            ..|:.:|.:|||||:|.||:|||||      |||:...:.:|........|..:.         .
  Fly   881 VNYQSWYKIEKIKVMGWTYLAACGLHVDHYTDFSVSVPISTNRESDKLQKSGSVRFAPMDGDEIM 945

  Fly   949 VRSRLESSIKEKNHDEVAFIMATFALDLMRVL-SVCNKAYAGEPFDRALSTGEIRIGISTGQIMA 1012
            ::....:.......|....:|..|||:|:|:| .:.:|....|. |..| ||.::|||:.|.:||
  Fly   946 IKDLHPTQATTNEDDNTILVMTEFALNLLRILRDIRSKGIFFEK-DSKL-TGSLKIGIAHGPVMA 1008

  Fly  1013 GVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPT 1077
            ||||.|:|||||||:.|||||||.|||:...|.||:.||..|.:|::.|.|||:|||||.|::||
  Fly  1009 GVVGLSKPHYDIWGHTVNMASRMTSTGVRDGIHVTESTANVLRDFNIRCTYRGMTFVKGVGQVPT 1073

  Fly  1078 YFVGIDKDLKFMSKKIDRLSENPS 1101
            |.|.:|::|.|.....|..|...|
  Fly  1074 YLVDLDENLHFQQHSPDNDSHKGS 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	59/259 (23%)
		CYCc	262..464	CDD:214485	92/201 (46%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	90/183 (49%)
		CYCc	831..1055	CDD:214485	97/239 (41%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	102/236 (43%)
CG32301	NP_728724.2	Nucleotidyl_cyc_III	283..439	CDD:299850	80/158 (51%)
		CYCc	812..1051	CDD:214485	97/240 (40%)
		Nucleotidyl_cyc_III	841..1076	CDD:299850	102/236 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940