DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXA and ACXC

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster

Alignment Length:	1104	Identity:	703/1104 - (63%)
Similarity:	862/1104 - (78%)	Gaps:	23/1104 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKNTYKTPY-RERFRRCNLEYTNERLWEQSYLKARCKELHLEEEYMKYKIRLMISSLTVFVPMLI 66
            :.|:.|:|. |:|.|.|:|:|.||||||.|||:.:||||:|||||..|::|||:|:||:|..:.|
  Fly     5 RTNSRKSPLKRKRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFI 69

  Fly    67 LLIVALQVIIWSFTEYTKYIYINAIFDLGSLILVTGLLSINFFEDFVIRHRWVMTFTSTLSAYVV 131
            :|.::...|...:.::...::.|.:..:.|.|||..:|||||.|.||.||||||..:|.||.|:|
  Fly    70 ILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLV 134

  Fly   132 VLGDIAFNTYYYYKSNWPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVIYFIHFMAFN 196
            ||.||...:|::||::|||||.:|||.||||||||||||.|.|||||.||||.||.:|:|.:.||
  Fly   135 VLTDIVMISYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFN 199

  Fly   197 EHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWLRQARRQESL 261
            .....:...|.|::|.|..|.|||||||||||||||||||:|||||:|||.||.|||.|..|||:
  Fly   200 AVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESI 264

  Fly   262 LLDSILPPQIAKPIQKSIKEKIIQPDN--DFYHLGTSRTAENFMSIQIHNDVSILYADLVNYTQL 324
            |||||||||||||:|:.||.||.|.:|  |.:.:| .||.|:||:||||.||||||||:||||.|
  Fly   265 LLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMG-PRTTESFMAIQIHPDVSILYADVVNYTHL 328

  Fly   325 TTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCVAGLGESDPDHATMAVSLGISMIA 389
            ||||||..|||||||||.|||:||.:|||||||||||||||||||...|||||...||||||||:
  Fly   329 TTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMIS 393

  Fly   390 NIKEVSVNRSLNIGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVSGRTL 454
            ||:||...|.|:|.||||||||:|.||:||:||||:||||.||.||:.||:||.|||||||||||
  Fly   394 NIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTL 458

  Fly   455 SSLNAEEYNIYPGTESAQKDPVLQKHPMSTYLLTA-------IPSLDSDKTISIVEGVPNLDLQT 512
            |.||..:|.|..||:.||.|||||.  :.|||||.       |.|:...::.|::| |.::|  .
  Fly   459 SMLNPADYTILSGTQKAQSDPVLQY--IHTYLLTGQVARESFITSIGGVRSSSVLE-VKSID--R 518

  Fly   513 VGSNRKSQILKPNLLSHEMREEFRKMPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVAFKDKSV 577
            :.|:|.||    :.::.|.|||||.|||||.....|..||.|...::|.:|::||||.||||.|:
  Fly   519 IRSSRPSQ----SSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSL 579

  Fly   578 EWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFICWYKKVC 642
            |||||||||:|||.|:.|.|||||||||||.|.|:......:|::::.||.||.||.:.|||.||
  Fly   580 EWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVC 644

  Fly   643 WWHSGQNEHRSYGKLSCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMSCEKDQYELDII 707
            ||.||:.|.|.|||.||..||:|||||||..||:|||:.|:..||.|||||:::|::|.|||..|
  Fly   645 WWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYI 709

  Fly   708 ESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCAEAVVFVLVVCFQYAFIF 772
            |||:|:|:||..||||||.:|||::||||:|||||||||.||..|.|.|.:.::|:|.||:||||
  Fly   710 ESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIF 774

  Fly   773 EHSVTTSPYLKAEIAHSCRVCMMLITMYAKERQSEFNTKMNYKLNLDLQNKQKSADVTNQSIIIL 837
            :||.||:|::|||:||..||||||:||||||||||||||||||||:|||||||:||:||||||||
  Fly   775 QHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIIL 839

  Fly   838 LNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYK 902
            ||||||||||::||:|:||||||||||||||||||||.||.|:||||||||||||.|||||:||:
  Fly   840 LNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINFPMNLPSLRVLNDIITQFDRLLTAYR 904

  Fly   903 QYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRL---ESSIKEKNHDE 964
            :||||||||||||||||||||||:|..|:....:|.::||..|:|..|:..   |:...:.|:||
  Fly   905 EYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDE 969

  Fly   965 VAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPV 1029
            |.|||.||||||||.|:.||:||:...|:|:||.|:|.||||:|:||||||||||||||||||||
  Fly   970 VVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPV 1034

  Fly  1030 NMASRMESTGLSGHIQVTKETAQTLEEFDVMCYYRGLTFVKGRGEIPTYFVGIDKDLKFMSKKI 1093
            |||||||||||.||||||:|:|:.|:|||:.|.|||:|||||||:|||||||||::|||||.|:
  Fly  1035 NMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKL 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	145/250 (58%)
		CYCc	262..464	CDD:214485	147/203 (72%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	133/182 (73%)
		CYCc	831..1055	CDD:214485	163/226 (72%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	158/223 (71%)
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	147/251 (59%)
		CYCc	293..468	CDD:214485	127/175 (73%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	120/158 (76%)
		CYCc	833..1060	CDD:214485	163/226 (72%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	158/223 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449934
Domainoid	1	1.000	187	1.000	Domainoid score	I6943
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27505
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0007605
OrthoInspector	1	1.000	-	-		otm48748
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.860