DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXA and GUCY2D

DIOPT Version :9

Sequence 1:	NP_620475.2	Gene:	ACXA / 53432	FlyBaseID:	FBgn0040510	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	410	Identity:	96/410 - (23%)
Similarity:	148/410 - (36%)	Gaps:	124/410 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   766 FQYAFIFEHSVTTS-PYLKAEIAHS------------CR----------VCMMLITMYAKERQSE 807
            |..|.|.:..|..| ||...|:...            ||          .|::|:.....| |.|
Human   730 FSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAE-QPE 793

  Fly   808 FNTKMN---------------------------YKLNLD--LQNKQKSADVTNQSIIILLNNILP 843
            ....|:                           |..||:  ::.:.:..::..|....||..:||
Human   794 LRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLP 858

  Fly   844 SHVVEVYLSSIAKHELYYEN---YRMVSVMFAMLTNFQMDLPSLRVLNDIITAFDRLLSAYKQYY 905
            ..|.|...:.......|:|.   |....|.|..::.....:..:.:|||:.|.||.::.::..|
Human   859 PSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVY- 922

  Fly   906 VVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMA 970
               |::.:|..||.|.||                                  .::|....|..:|
Human   923 ---KVETIGDAYMVASGL----------------------------------PQRNGQRHAAEIA 950

  Fly   971 TFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRM 1035
            ..:||::..:......:..|...|      ||||:.:|..:|||||.:.|.|.::|:.||.||||
Human   951 NMSLDILSAVGTFRMRHMPEVPVR------IRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRM 1009

  Fly  1036 ESTGLSGHIQVTKETAQTLEEFD--VMCYYRGLTFVKGRGEIPTYFV----GIDKDLKFMSKKID 1094
            |||||...|.|...|...|...|  .....||.|.:||:|...|:::    |.:|.:
Human  1010 ESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPI-------- 1066

  Fly  1095 RLSENPSNPDL-----NHDL 1109
                 |..|||     ||.:
Human  1067 -----PKPPDLQPGSSNHGI 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831
		CYCc	262..464	CDD:214485
		Nucleotidyl_cyc_III	306..489	CDD:299850
		CYCc	831..1055	CDD:214485	60/226 (27%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	62/225 (28%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945	16/81 (20%)
		HNOBA	<820..865	CDD:369471	10/44 (23%)
		CYCc	846..1036	CDD:214485	62/233 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103		6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900