Protein Alignment ACXA and GUCY2F

DIOPT Version :9

• Sequence 1: NP_620475.2
• Gene: ACXA / 53432
• FlyBaseID: FBgn0040510
• Length: 1112
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 995
• Identity: 200/995 - (20%)
• Similarity: 354/995 - (35%)
• Gaps: 359/995 - (36%)

  Fly   243 YQFITEEIWLRQARRQ--ESLLLDSILP---------PQIAKPIQKSIKEKIIQPDNDFYHLGTS 296
            ||..||    ..||.:  |.|..|.:.|         ..||:.:..::||.        ...|.:
Human   324 YQAFTE----AAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKEN--------GQAGAA 376

  Fly   297 RTAENFMSIQIHNDVSILYAD-----LVNYTQLTTTLTVEKLVKVLHDLY-ARFDLAALSFKVQR 355
            ...::..::|.|....::..|     :..|..|.|.|...:    ||..| ...::..|.|....
Human   377 SLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWE----LHSTYTVDMEMELLRFGGTP 437

  Fly   356 IKFLG--------DCYY-----CVAGLGESDPDHATM-AVSLGISMIA----------NIKEVSV 396
            |.|.|        .|::     |..|:   ||..|.| .::|.|::::          .|.::.:
Human   438 IHFPGGRPPRADAKCWFAEGKICHGGI---DPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQL 499

  Fly   397 NRSLN-----------IGMRIGVHSGTLFAGVIGKAKLQYDIWGADVNIASRLEATGSPGYVHVS 450
            .:..|           |....|...|:       :|.:.:       .|.|.:::..||.....|
Human   500 IKGPNRILLTLEDVTFINPHFGSKRGS-------RASVSF-------QITSEVQSGRSPRLSFSS 550

  Fly   451 GRTLSSLNAEEYN--IYPGTESAQKDPV-LQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQT 512
            | :|:....|..|  ||.|      |.| |:|..:..:                  |    ||::
Human   551 G-SLTPATYENSNIAIYEG------DWVWLKKFSLGDF------------------G----DLKS 586

  Fly   513 VGSNRKSQILKPNLLSHEMREEFRK---MPVGGFKFQFPWSRRERNLKNEKVERDLGIFCVA--F 572
            :.| |.|.:.       ||.::.|.   .|:.||.:                  |.|:|.:.  |
Human   587 IKS-RASDVF-------EMMKDLRHENINPLLGFFY------------------DSGMFAIVTEF 625

  Fly   573 KDK-SVEWNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFLLFIC 636
            ..: |:|       |.:....|.|.|                :|.:.:::::|
Human   626 CSRGSLE-------DILTNQDVKLDW----------------MFKSSLLLDLI------------ 655

  Fly   637 WYKKVCWWHSGQNEHRSY--GKL---SCAIFHLFEKIQHSFVLRLTVYMMIILCYYMVISLILMS 696
              |.:.:.|     ||.:  |:|   :|.       :...|||::|.|     .:..::.::.:|
Human   656 --KGMKYLH-----HREFVHGRLKSRNCV-------VDGRFVLKVTDY-----GFNDILEMLRLS 701

  Fly   697 CEKDQYELDII-----------ESKLYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKT 750
            .|:...| :::           .|:|.::..|.::    :|......::.|..:....:|
Human   702 EEESSME-ELLWTAPELLRAPRGSRLGSFAGDVYS----FAIIMQEVMVRGTPFCMMDLP----- 756

  Fly   751 FIGCAEAVVFVLVVCFQYAFIFEHSVTTSPYLKAEIAHSCRVCMMLITM---YAKERQSEFNTKM 812
                |:.::..|.         :......|.:..|  |:...|:.|:..   .|.|::..|:...
Human   757 ----AQEIINRLK---------KPPPVYRPVVPPE--HAPPECLQLMKQCWAEAAEQRPTFDEIF 806

  Fly   813 N-----------------------YKLNLD--LQNKQKSADVTNQSIIILLNNILPSHVVEVYLS 852
            |                       |..||:  ::.:.:..::..|....||..:||..|.|
Human   807 NQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAE---- 867

  Fly   853 SIAKH-ELYYENYRMVSVMFAMLTNF----QMDLP--SLRVLNDIITAFDRLLSAYKQYYVVEKI 910
            |:.|. .:..|.:.:|::.|:.:..|    .|..|  .:.:|||:.|.||.::.::..|    |:
Human   868 SLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVY----KV 928

  Fly   911 KVVGCTYMAACGLDFSLIENLDSNSNFGSTSLSSELEQVRSRLESSIKEKNHDEVAFIMATFALD 975
            :.:|..||.|.||                                  .::|....|..:|..:||
Human   929 ETIGDAYMVASGL----------------------------------PKRNGSRHAAEIANMSLD 959

  Fly   976 LMRVLSVCNKAYAGEPFDRALSTGEIRIGISTGQIMAGVVGASQPHYDIWGNPVNMASRMESTGL 1040
            ::..:......:..|...|      ||||:.:|.::|||||.:.|.|.::|:.||.|||||||||
Human   960 ILSSVGTFKMRHMPEVPVR------IRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1018

  Fly  1041 SGHIQVTKETAQTL----EEFDVMCYYRGLTFVKGRGEIPTYF-VG-------------IDKD-- 1085
            ...|.|:..|...|    |.::|  ..||.|.:||:|...|:: :|             :|||
Human  1019 PYRIHVSLSTVTILQNLSEGYEV--ELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQ 1081

  Fly  1086 ----------LKFMSKKIDR 1095
                      ..|..:|.:|
Human  1082 VGHGLQPVEIAAFQRRKAER 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXA	NP_620475.2	AC_N	<42..291	CDD:292831	14/58 (24%)
		CYCc	262..464	CDD:214485	46/253 (18%)
		Nucleotidyl_cyc_III	306..489	CDD:299850	46/226 (20%)
		CYCc	831..1055	CDD:214485	64/234 (27%)
		Nucleotidyl_cyc_III	859..1080	CDD:299850	64/231 (28%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	27/126 (21%)
		ANF_receptor	75..412	CDD:279440	20/99 (20%)
		PKc_like	545..815	CDD:304357	68/403 (17%)
		HNOBA	<824..869	CDD:285003	10/48 (21%)
		CYCc	848..1040	CDD:214485	65/239 (27%)
		Guanylate_cyc	875..1062	CDD:278633	64/232 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810