DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXA and GUCY2C

DIOPT Version :9

Sequence 1:NP_620475.2 Gene:ACXA / 53432 FlyBaseID:FBgn0040510 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_004954.2 Gene:GUCY2C / 2984 HGNCID:4688 Length:1073 Species:Homo sapiens


Alignment Length:1124 Identity:216/1124 - (19%)
Similarity:348/1124 - (30%) Gaps:464/1124 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 DIAFNTY-----YYYKSN-------WPLNTLYDVFVLCMIYMFLPIPSSKAAALLAISVSLTYVI 187
            |:.|.||     |.||:.       |.||                          |:..|::|  
Human   179 DLPFKTYSWSTSYVYKNGTETEDCFWYLN--------------------------ALEASVSY-- 215

  Fly   188 YFIHFMAFNEHNVAKYVHGLDIVSIDFFHYLGFNMMGIFFRIMNDTMVRSSFLDRYQFITEEIWL 252
                                      |.|.|||.::                            |
Human   216 --------------------------FSHELGFKVV----------------------------L 226

  Fly   253 RQARRQESLLLDSILPPQIAKPIQKSIKEKII----QPDNDFYHLGTSRTAENFMSIQIHNDVSI 313
            ||.:..:.:|:|            .:.|..:|    .|:..:...|....||         |:.|
Human   227 RQDKEFQDILMD------------HNRKSNVIIMCGGPEFLYKLKGDRAVAE---------DIVI 270

  Fly   314 LYADLVN------------YTQLTTTLTVEKLVKVLHDLYARFDLAALSFKVQRIKFLGDCYYCV 366
            :..||.|            |.:....||:.....:|:..::|                       
Human   271 ILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSR----------------------- 312

  Fly   367 AGLGESDPDHATMAVSLGISMIANIKEVSVNRSLNIGMRIGVHS--GTLFAGVIGKAKLQYDIWG 429
             .|..:..|.| :|...||.:..::.::.:....||......|:  ...|.|..|...|  |.||
Human   313 -NLSPTKRDFA-LAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTL--DDWG 373

  Fly   430 ADVNIASRLEATGSPGYVHVSGRTLSSLNAEEYNI-----------YP--------GTESAQKDP 475
             ||:....|..|              |::.::|.:           ||        ...|...:.
Human   374 -DVDSTMVLLYT--------------SVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPND 423

  Fly   476 VLQKHPMSTYLLTAIPSLDSDKTISIVEGVPNLDLQTVGSNRKSQILKPNLLSHEMREEFRKMPV 540
            :..:.|.  .|:.|:.:|.....:.::     :.|..:...||...|:....||...|..     
Human   424 ITGRGPQ--ILMIAVFTLTGAVVLLLL-----VALLMLRKYRKDYELRQKKWSHIPPENI----- 476

  Fly   541 GGFKFQFPWSRRERNLKNEKVE-----------------------RDL----GIFCVAFKDKSVE 578
                  ||....|.|..:.|::                       :||    |.|.   :.:.:|
Human   477 ------FPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFT---EKQKIE 532

  Fly   579 WNYLHQPDYIFKYSVALGWGIGCCLIYIQSVNNSDIFYTGVVINIIAFFVLTFL----------- 632
            .|.|.|.||.                      |...||..|.::.:.|.|:.:.           
Human   533 LNKLLQIDYY----------------------NLTKFYGTVKLDTMIFGVIEYCERGSLREVLND 575

  Fly   633 -------LFICWYKKV----------CWWHSGQNE-HRSYGKLSCAIFHLFEKIQHSFVLRLT-- 677
                   .|:.|..|:          .:.||.:.| |......:|.       :....|:::|  
Human   576 TISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCV-------VDSRMVVKITDF 633

  Fly   678 -----------------------------VYMMIILCYYMVI---SLILMSCEKDQYELDIIESK 710
                                         ||...|:...:::   :...:|| :|:.|      |
Human   634 GCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSC-RDRNE------K 691

  Fly   711 LYNYDMDPFTCFHPWAYTNMMALILGMSYTFARIPFALKTFIGCA---EAVVFVLVV-CFQ---- 767
            ::..:...                 ||.      ||....|:..|   |..|::||. |::    
Human   692 IFRVENSN-----------------GMK------PFRPDLFLETAEEKELEVYLLVKNCWEEDPE 733

  Fly   768 -----------YAFIFE--HSVTTSPYLKAEIAHSCRVCMMLITMYAK--ERQSEFNTKMNYKLN 817
                       .|.||.  |......|:...|..        :.:|::  |...|..|:: ||..
Human   734 KRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRR--------LQLYSRNLEHLVEERTQL-YKAE 789

  Fly   818 LDLQNKQKSADVTNQSIIILLNNILPSHVVEVYLSSIAKHELYYENYRMVSVMFAMLTNF----- 877
            .|      .||..|   .:||..::...:.|   ....:.|||.|    |::.|:.:..|     
Human   790 RD------RADRLN---FMLLPRLVVKSLKE---KGFVEPELYEE----VTIYFSDIVGFTTICK 838

  Fly   878 -QMDLPSLRVLNDIITAFDRLLSAYKQYYVVEKIKVVGCTYMAACGLDFSLIENLDSNSNFGSTS 941
             ...:..:.:||||..:||.::..:..|    |::.:|..||.|.||.       ..|.|..:..
Human   839 YSTPMEVVDMLNDIYKSFDHIVDHHDVY----KVETIGDAYMVASGLP-------KRNGNRHAID 892

  Fly   942 LSSELEQVRSRLESSIKEKNHDEVAFIMATFALDLMRVLSVCNKAYAGEPFDRALSTGEIRIGIS 1006
            ::                |...|:...|.||.|:.:..|.:.                 ||||:.
Human   893 IA----------------KMALEILSFMGTFELEHLPGLPIW-----------------IRIGVH 924

  Fly  1007 TGQIMAGVVGASQPHYDIWGNPVNMASRMESTGLSGHIQVTKETAQTLEEFDVMCYY--RGLTFV 1069
            :|...|||||...|.|.::|:.||.|||||||||...|.|:..|...|:..:....|  ||.|::
Human   925 SGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYL 989

  Fly  1070 KGRGEIPTYFVGIDKDLKF 1088
            ||||...||::...||.||
Human   990 KGRGNETTYWLTGMKDQKF 1008

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXANP_620475.2 AC_N <42..291 CDD:292831 26/171 (15%)
CYCc 262..464 CDD:214485 40/219 (18%)
Nucleotidyl_cyc_III 306..489 CDD:299850 37/215 (17%)
CYCc 831..1055 CDD:214485 61/229 (27%)
Nucleotidyl_cyc_III 859..1080 CDD:299850 67/228 (29%)
GUCY2CNP_004954.2 PBP1_GC_C_enterotoxin_receptor 35..415 CDD:107364 63/380 (17%)
PK_GC-C 480..750 CDD:270946 50/331 (15%)
Pkinase_Tyr 502..745 CDD:285015 45/304 (15%)
CYCc 788..979 CDD:214485 65/250 (26%)
Guanylate_cyc 815..1002 CDD:278633 68/234 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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